Disruption of KEX1 gene reduces the proteolytic degradation of secreted two-chain Insulin glargine in Pichia pastoris

Title
Disruption of KEX1 gene reduces the proteolytic degradation of secreted two-chain Insulin glargine in Pichia pastoris
Authors
Keywords
Pichia pastoris, Two-chain glargine, Cre/lox mechanism, Gene inactivation, Marker rescue
Journal
PROTEIN EXPRESSION AND PURIFICATION
Volume 118, Issue -, Pages 1-9
Publisher
Elsevier BV
Online
2015-10-25
DOI
10.1016/j.pep.2015.10.002

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