P110β Inhibition Reduces Histone H3K4 Di-Methylation in Prostate Cancer

Regulation of the Phosphatidylinositide 3-Kinase Pathway by the Lipid Phosphatase PTEN

(2016) C. Bassi et al.   CLINICAL CHEMISTRY

Targeting persistent androgen receptor signaling in castration-resistant prostate cancer

(2016) Laura Graham et al.   MEDICAL ONCOLOGY

PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer

(2016) Jennifer M. Spangle et al.   Cell Reports

The interplay of histone modifications - writers that read

(2015) T. Zhang et al.   EMBO REPORTS

Nanomicellar TGX221 blocks xenograft tumor growth of prostate cancer in nude mice

(2015) Ruibao Chen et al.   PROSTATE

Discovery and Optimization of Pyrimidone Indoline Amide PI3Kβ Inhibitors for the Treatment of Phosphatase and Tensin Homologue (PTEN)-Deficient Cancers

(2014) Victor Certal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of diet in prostate cancer: the epigenetic link

(2014) D P Labbé et al.   ONCOGENE

Epigenetic modifications in prostate cancer

(2014) Marjolaine Ngollo et al.   Epigenomics

Lysine-Specific Demethylase 1 Has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity

(2014) Changmeng Cai et al.   Cell Reports

Deregulated expression of selected histone methylases and demethylases in prostate carcinoma

(2013) Filipa Quintela Vieira et al.   ENDOCRINE-RELATED CANCER

Histone lysine demethylases as targets for anticancer therapy

(2013) Jonas W. Højfeldt et al.   NATURE REVIEWS DRUG DISCOVERY

Cav1.3 channel α1D protein is overexpressed and modulates androgen receptor transactivation in prostate cancers11This work was partially supported by grants from DoD PCRP program (W81XWH-09-1-0455) and KUMC Valk Foundation to Dr Benyi Li, and grants from China Natural Science Foundation to Dr Benyi Li (NSFC #81172427) and Dr Jun Yang (NSFC #81101927). This project was also supported by the “Chutian Scholar” program funded by Hubei Province of China dedicated to China Three Gorges University.

(2013) Ruibao Chen et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Global Levels of H3K27me3 Track with Differentiation in Vivo and Are Deregulated by MYC in Prostate Cancer

(2012) Laxmi G. Pellakuru et al.   AMERICAN JOURNAL OF PATHOLOGY

Epigenetic biomarkers in prostate cancer: Current and future uses

(2012) Karen Chiam et al.   CANCER LETTERS

Prodrug Strategy for PSMA-Targeted Delivery of TGX-221 to Prostate Cancer Cells

(2012) Yunqi Zhao et al.   MOLECULAR PHARMACEUTICS

Functional Characterization of an Isoform-Selective Inhibitor of PI3K-p110β as a Potential Anticancer Agent

(2012) Jing Ni et al.   Cancer Discovery

Alterations of global histone H4K20 methylation during prostate carcinogenesis

(2012) Turang E Behbahani et al.   BMC Urology

Epigenetic Silencing Mediated through Activated PI3K/AKT Signaling in Breast Cancer

(2011) T. Zuo et al.   CANCER RESEARCH

Global histone modification of histone H3 in colorectal cancer and its precursor lesions

(2011) Tadao Nakazawa et al.   HUMAN PATHOLOGY

Reversal of Histone Methylation: Biochemical and Molecular Mechanisms of Histone Demethylases

(2010) Nima Mosammaparast et al.   Annual Review of Biochemistry

Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

(2010) T. Bianco-Miotto et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing

(2010) Khairul I. Ansari et al.   FEBS Journal

Phosphoinositide 3-Kinase Pathway Activation in Phosphate and Tensin Homolog (PTEN)-deficient Prostate Cancer Cells Is Independent of Receptor Tyrosine Kinases and Mediated by the p110β and p110δ Catalytic Subunits

(2010) Xinnong Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Xenoestrogen-Induced Regulation of EZH2 and Histone Methylation via Estrogen Receptor Signaling to PI3K/AKT

(2010) Tiffany G. Bredfeldt et al.   MOLECULAR ENDOCRINOLOGY

The epigenome as a therapeutic target in prostate cancer

(2010) Antoinette S. Perry et al.   Nature Reviews Urology

A constitutively activated form of the p110  isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice

(2010) S. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Levels of Histone Modifications Predict Prognosis in Different Cancers

(2009) David B. Seligson et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanisms of transcriptional repression by histone lysine methylation

(2009) Philip Hublitz et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Genome-Wide Profiling of Histone H3 Lysine 4 and Lysine 27 Trimethylation Reveals an Epigenetic Signature in Prostate Carcinogenesis

(2009) Xi-Song Ke et al.   PLoS One

Global levels of histone modifications predict prostate cancer recurrence

(2009) Jörg Ellinger et al.   PROSTATE

PTEN and the PI3-Kinase Pathway in Cancer

(2008) Nader Chalhoub et al.   Annual Review of Pathology-Mechanisms of Disease

NGF/PI3K signaling-mediated epigenetic regulation of delta opioid receptor gene expression

(2008) Yulong L. Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphoinositide 3-OH kinase p85α and p110β are essential for androgen receptor transactivation and tumor progression in prostate cancers

(2008) Q Zhu et al.   ONCOGENE

PTEN-deficient cancers depend on PIK3CB

(2008) S. Wee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA