Article
Psychiatry
Shushan Zheng, Sherry Kit Wa Chan, Jimmy Lee
Summary: This study surveyed psychiatrists in Hong Kong and Singapore to understand their familiarity and prescribing practices in treatment-resistant schizophrenia and clozapine-resistant schizophrenia. The results showed that, despite the familiarity with treatment guidelines, delays in prescribing clozapine still occur. The study also found regional differences in alternative treatment methods to clozapine.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Julia M. Lappin, Kimberley Davies, Maryanne O'Donnell, Ishan C. Walpola
Summary: This study aimed to understand the use of clozapine and electroconvulsive therapy (ECT) in individuals with treatment-resistant psychosis. The study found that the utilization of these treatments was low and clozapine trials were often terminated prematurely without adequate testing. The study suggests strategies should be implemented to optimize the use of clozapine therapy and ECT in clinical settings to improve the therapeutic effectiveness for treatment-resistant psychosis.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Can Ugurpala, Ertug Berberoglu, Utku Ozkan, Selin Akisk Genc, Nuran Caglar Tanriverdi, Damla Inhanli, Chouda Ali, Alp Ucok
Summary: This study investigates the relationship between minor physical anomalies (MPA) and treatment resistance in schizophrenia (TRS). It found that TRS patients had higher total MPA score, and MPAs in the eye and mouth regions were more frequent in TRS patients compared to non-TRS patients. The total MPA score was correlated to BPRS-E total and BPRS positive scores in TRS patients. These findings suggest that MPA might contribute to treatment resistance in schizophrenia.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Alejandra Zazueta, Tito Castillo, Alvaro Cavieres, Rene Gonzalez, Maximiliano Abarca, Rodrigo R. Nieto, Javier Deneken, Cristian Araneda, Pablo R. Moya, M. Leonor Bustamante
Summary: The response to conventional antipsychotic drugs and clozapine treatment is associated with genetic variations, but more research is needed for personalized prescriptions.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Ming-Huan Zhu, Zhen-Jing Liu, Qiong-Yue Hu, Jia-Yu Yang, Ying Jin, Na Zhu, Ying Huang, Dian-Hong Shi, Min-Jia Liu, Hong-Yang Tan, Lei Zhao, Qin-Yu Lv, Zheng-Hui Yi, Feng-Chun Wu, Ze-Zhi Li
Summary: This study aimed to investigate the efficacy of amisulpride augmentation therapy in treating patients with treatment-resistant schizophrenia. The results showed that amisulpride augmentation therapy improved psychiatric symptoms and cognitive function with tolerability and safety.
MILITARY MEDICAL RESEARCH
(2022)
Article
Psychiatry
Laura Orsolini, Silvia Bellagamba, Virginio Salvi, Umberto Volpe
Summary: This article describes a 20-year-old patient with clozapine-resistant schizophrenia and comorbid cannabinoid use disorder, who was successfully treated with a combination of clozapine and brexpiprazole, and later switched to clozapine with long-acting injectable aripiprazole.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Psychiatry
Simon S. Y. Lui, Stanley S. L. Yip, Ya Wang, Karen S. Y. Hung, Karen K. Y. Ho, Kirby C. M. Tsang, Hera K. H. Yeung, Eric F. C. Cheung, Raymond C. K. Chan
Summary: The study investigated the trajectory of neurological soft signs (NSS) in schizophrenia patients and found that NSS worsened over time in treatment-resistant patients. This suggests that NSS may be useful in identifying treatment resistance in first-episode schizophrenia patients, reflecting the development of underlying neuropathology.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Psychiatry
Mattia Campana, Peter Falkai, Dan Siskind, Alkomiet Hasan, Elias Wagner
Summary: This systematic review and meta-analysis aimed to characterize ultra-treatment-resistant Schizophrenia patients and investigate the consistency in CRS definitions between studies. The results showed a large heterogeneity of CRS definitions and insufficient guidelines implementation. A new score modeled on a best practice definition was offered to help future trials increase their reliability.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Psychiatry
Elias Wagner, Dan Siskind, Peter Falkai, Oliver Howes, Christoph Correll, Jimmy Lee, William G. Honer, John M. Kane, Emilio Fernandez-Egea, Thomas R. E. Barnes, Alkomiet Hasan
Summary: This study conducted an online Delphi survey to develop consensus recommendations for the optimization of clozapine monotherapy. The recommendations include specific treatment options for certain symptoms and management of side effects. The study results provide guidance for clinical decision-making and future research in treatment-resistant schizophrenia.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Clinical Neurology
Chuanjun Zhuo, Yong Xu, Haibo Wang, Chunhua Zhou, Jian Liu, Xiaocui Yu, Hailin Shao, Hongjun Tian, Tao Fang, Qianchen Li, Jiayue Chen, Shuli Xu, Xiaoyan Ma, Weiliang Yang, Cong Yao, Bo Li, Anqu Yang, Yuhui Chen, Guoyong Huang, Chongguang Lin
Summary: Clozapine-induced metformin-resistant prediabetes/diabetes is common in the early-treatment resistance subtype of treatment-resistant schizophrenia and is associated with poor clinical efficacy of clozapine.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Editorial Material
Psychiatry
Rodolfo Furlan Damiano, Belquiz S. Avrichir, Debora L. Melzer-Ribeiro, Paulo Clemente Sallet, Helio Elkis
Summary: This is a case report of a patient with treatment-resistant schizophrenia who has failed to respond to clozapine and electroconvulsive therapy, and has a history of multiple suicide attempts. Evidence-based clinical decisions for managing such patients were discussed.
PSYCHIATRY RESEARCH
(2021)
Article
Psychology, Clinical
Jerome Brunelin, Filipe Galvao, Marine Mondino
Summary: This retrospective study investigated the therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) in patients with treatment-resistant auditory verbal hallucinations. The results showed that low frequency rTMS could significantly decrease these symptoms.
INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
(2023)
Article
Psychiatry
Graham Blackman, Ebenezer Oloyede, Mark Horowitz, Robert Harland, David Taylor, James MacCabe, Philip McGuire
Summary: There is currently no formal guidance on how to safely discontinue clozapine treatment, which poses risks of psychotic relapse and withdrawal symptoms.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychiatry
Leeba Rezaie, Azadeh Nazari, Roya Safari-Faramani, Shamarina Shohaimi, Habibolah Khazaie
Summary: This study investigated the knowledge and attitude of Iranian psychiatrists towards the use of clozapine. Most respondents acknowledged prescribing clozapine and believed it to be more effective than other antipsychotic drugs. However, concerns about the safety of clozapine were common. Psychiatrists with longer work experience and academic positions were more optimistic towards clozapine use.
Article
Psychiatry
Kohei Kitagawa, Shusuke Uekusa, Kazuhiro Matsuo, Kei Moriyama, Tatsuro Yamamoto, Yuji Yada, Masafumi Kodama, Yoshiki Kishi, Takashi Yoshio
Summary: This study aimed to evaluate the risk factors for clozapine-induced central nervous system abnormalities in patients with schizophrenia. Results showed that concomitant lithium usage and shorter illness durations were associated with an increased risk of CNS abnormalities. Clinicians are advised to closely monitor patients for CNS abnormalities, especially those with shorter illness durations, when using lithium in combination with clozapine.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Psychiatry
Caleb Labonte, Naista Zhand, Angela Park, Philip D. Harvey
Summary: Evidence suggests that the variable response to antipsychotic treatment in schizophrenia reflects distinct biological subtypes associated with changes in the immune system. Different subtypes of schizophrenia patients show varying alterations in inflammatory markers during treatment, with only the treatment-responsive group exhibiting a significant decrease in inflammatory markers post-treatment.Persistent inflammation may be a biological trait marker of treatment resistance in schizophrenia.
PSYCHIATRY RESEARCH
(2022)
Article
Behavioral Sciences
Michal Hajduk, Amy E. Pinkham, David L. Penn, Philip D. Harvey, Noah J. Sasson
Summary: Autistic adults and those with schizophrenia demonstrate similar levels of reduced social cognitive performance at the group level, but a significant portion of both groups still exhibit normative performance. Nearly half of autistic participants performed in the normal range, while over a third of participants with schizophrenia also did, accompanied by a hostility bias not commonly found in autistic individuals. These findings challenge the assumption that difficulties in social cognition are a uniform characteristic of these clinical conditions in those without intellectual disability.
Article
Psychology, Clinical
Varsha D. Badal, Colin A. Depp, Philip D. Harvey, Robert A. Ackerman, Raeanne C. Moore, Amy E. Pinkham
Summary: Inaccurate self-assessment is common among people with serious mental illness and it negatively affects their functional outcomes. This study used network modeling to explore the temporal relationships between confidence, accuracy judgments, and feedback. The results suggest that individuals with schizophrenia and bipolar disorder have stronger connections between confidence and accuracy judgments, but weaker associations between feedback and subsequent judgments compared to healthy controls.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Nina Dalkner, Raeanne C. Moore, Colin A. Depp, Robert A. Ackerman, Amy E. Pinkhame, Philip D. Harvey
Summary: Mood states have been found to be correlated with self-assessment accuracy in various functional domains and psychiatric conditions. This study used ecological momentary assessment to examine the association between longitudinally assessed moods and immediate self-assessment accuracy of cognitive performance in individuals with schizophrenia and bipolar disorder. The results showed that negative moods were significantly associated with impairments in self-assessment accuracy and cognitive performance in individuals with bipolar disorder, but not in those with schizophrenia.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Lisa R. Steenkamp, Emma M. Parrish, Samantha A. Chalker, Varsha D. Badal, Amy E. Pinkham, Philip D. Harvey, Colin A. Depp
Summary: This study examined the impact of childhood trauma on day-to-day social experiences among individuals with psychotic disorders or affective disorders. The results showed that higher levels of childhood trauma were associated with increased perceived threat, negative self-perception, reduced social motivation, desire for social avoidance, and lower sense of belongingness during recent social interactions. These negative social perceptions were primarily linked with emotional abuse and neglect. It was also found that paranoia was more strongly associated with negative social perceptions among individuals with high levels of trauma. However, childhood trauma was not associated with the frequency or type of social interactions.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Nathan A. Kimbrel, Allison E. Ashley-Koch, Xue J. Qin, Jennifer H. Lindquist, Melanie E. Garrett, Michelle F. Dennis, Lauren P. Hair, Jennifer E. Huffman, Daniel A. Jacobson, Ravi K. Madduri, Jodie A. Trafton, Hilary Coon, Anna R. Docherty, Niamh Mullins, Douglas M. Ruderfer, Philip D. Harvey, Benjamin H. McMahon, David W. Oslin, Jean C. Beckham, Elizabeth R. Hauser, Michael A. Hauser
Summary: This study aimed to identify the genetic basis of suicidal thoughts and behaviors. Through genome-wide association analysis, several risk loci for suicide were identified, and some of these loci were replicated in independent samples, providing evidence for their involvement in suicide.
Article
Psychiatry
Emma M. Parrish, Philip D. Harvey, Robert A. Ackerman, Amy E. Pinkham, Colin A. Depp, Jason Holden, Eric Granholm
Summary: This study aims to understand the relationship between positive affect (PA) and negative affect (NA) among people with schizophrenia, and explore the impact of social context on mood variability. The results show that some patients with schizophrenia do not experience negative affect, some experience both positive and negative affect, and some show a more normative affect pattern.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
L. Okruszek, M. Jarkiewicz, A. Piejka, M. Chrustowicz, M. Krawczyk, A. Schudy, P. D. Harvey, D. L. Penn, K. Ludwig, M. F. Green, A. E. Pinkham
Summary: This study investigated the relationship between loneliness and neuro- and social cognitive mechanisms in patients with schizophrenia. The results showed that patients reported higher levels of loneliness compared to healthy controls, and loneliness was positively correlated with negative and affective symptoms in patients. It was also found that loneliness was negatively associated with mentalizing and emotion recognition abilities in patients with social-cognitive impairments, but not in those who performed at normative levels.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Psychiatry
Rohit Voleti, Stephanie M. Woolridge, Julie M. Liss, Melissa Milanovic, Gabriela Stegmann, Shira Hahn, Philip D. Harvey, Thomas L. Patterson, Christopher R. Bowie, Visar Berisha
Summary: Automated language analysis is a useful tool in clinical research involving individuals with mental health disorders. This study focuses on using linguistic output to assess functional outcomes and predicts clinical variables related to mental health status and competency. The results show that language features are valuable for predicting these variables.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Psychiatry
Dylan J. Jester, Michael L. Thomas, Emily T. Sturm, Philip D. Harvey, Matcheri Keshavan, Beshaun J. Davis, Shekhar Saxena, Rajesh Tampi, Heather Leutwyler, Michael T. Compton, Barton W. Palmer, Dilip Jeste
Summary: Social determinants of health (SDoHs) have a significant impact on the health of individuals with schizophrenia-spectrum psychotic disorders (SSPDs), with risk factors including childhood abuse, parental psychopathology, parental communication problems, bullying, and low socioeconomic status in urban areas. Racial/ethnic discrimination and social fragmentation are also associated with the prevalence and symptoms of psychosis. Homeless populations and seriously mentally ill individuals are more likely to experience food insecurity. Further research is needed to understand the positive factors and develop interventions to reduce the adverse health impacts of SDoHs.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Psychiatry
Sara E. Jones, Philip D. Harvey
Summary: Cognitive impairment is strongly related to disability and educational attainment, and previous drug development efforts have focused on transmitter systems associated with specific conditions. However, recent genomics studies suggest common influences on cognition across populations and conditions. Stimulation of muscarinic cholinergic receptors (M1 and M4) shows potential for enhancing cognition and treating psychotic symptoms, especially with recent developments improving tolerability. The M1 and M4 receptor stimulation may serve as a trans-diagnostic treatment model.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychology, Clinical
Arundati Nagendra, Chih-Wei Joshua Liu, Kim T. Mueser, Philip D. Harvey, Colin A. Depp, Raeanne C. Moore, Beshaun Davis, Amy E. Pinkham
Summary: This study examined the ethno-racial differences in daily functioning among individuals with serious mental illnesses, specifically focusing on non-Latinx White, non-Latinx Black, and Latinx participants. The findings indicate that Black participants engaged more in solitary or passive leisure activities compared to White and Latinx participants, and reported less vocational activity and home-based active leisure. While some of these differences were explained by socioeconomic status and symptom severity, further research is needed to explore sociocultural and racism-related factors. Clinical implications and suggestions for future research are discussed.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Article
Psychiatry
Varsha D. Badal, Colin A. Depp, Amy E. Pinkham, Philip D. Harvey
Summary: This study aimed to investigate the metacognitive construct of Introspective Accuracy (IA) by exploring the alignment between self-generated accuracy judgments, confidence, and objective information regarding performance. The results showed a sustained disconnect between self-assessments and actual performance, and the cognitive origins of IA are still unclear. The time-series analysis revealed that confidence levels were affected to a different extent in participants with schizophrenia and bipolar disorder in specific tasks.
SCHIZOPHRENIA RESEARCH-COGNITION
(2023)
Article
Psychiatry
Angelo Sadeghpoura, David L. Poggec, Elizabeth M. O'Donoghue, Tim Bigdelif, Alex O. Rothbaum, Philip D. Harvey
Summary: Half of individuals have experienced a trauma sufficient to meet the criteria for PTSD, and the relationship between intelligence and trauma is unclear. A study was conducted on child and adolescent inpatients, assessing their intelligence, academic achievement, and trauma experiences. The results showed that those who experienced physical and sexual abuse performed poorly in intellectual domains, and exposure to substance abuse was associated with lower intelligence and higher CTQ scores.
PSYCHIATRY RESEARCH
(2023)
Meeting Abstract
Neurosciences
Courtney Dowell-Esquivel, Peter Kallestrup, Sara Czaja, Colin A. Depp, John Saber, Philip D. Harvey
BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
