Article
Biochemistry & Molecular Biology
Claudia Bonechi, Fariba Fahmideh Mahdizadeh, Luigi Talarico, Simone Pepi, Gabriella Tamasi, Gemma Leone, Marco Consumi, Alessandro Donati, Agnese Magnani
Summary: Glaucoma, a group of neurodegenerative diseases, is the second leading cause of irreversible blindness worldwide. The limited penetration of drugs through the ocular barrier reduces the systemic bioavailability, leading to the need for frequent drug administration and potential toxic effects. Liposomes and other novel drug-delivery systems can enhance the therapeutic efficacy of antiglaucomatous drugs by improving drug penetration, bioavailability, sustained release, tissue targeting, and reduction in intraocular pressure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Leila Mousavifar, Jordan D. Lewicky, Alexis Taponard, Rahul Bagul, Madleen Rivat, Shuay Abdullayev, Alexandrine L. Martel, Nya L. Fraleigh, Arnaldo Nakamura, Frederic J. Veyrier, Hoang-Thanh Le, Rene Roy
Summary: This study reports the chemical synthesis of a novel series of mannosylated neoglycolipids with the goal of further improving on the previous glyconanoparticles. By using a new synthetic method, stable neoglycoliposomes were successfully prepared, and their potential applications in improving cellular uptake and biological activity were explored.
Article
Pharmacology & Pharmacy
Carla Caddeo, Daniela Lucchesi, Xavier Fernandez-Busquets, Donatella Valenti, Giuseppe Penno, Anna Maria Fadda, Laura Pucci
Summary: This study developed a vesicular formulation for cutaneous applications containing resveratrol and Tween80. The nanosized vesicles showed good storage stability and were able to protect skin cells from oxidative stress. The formulation represents an easy-to-prepare, reproducible, up-scaled, and efficient means of delivering resveratrol and enhancing its biological activity in vitro.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Thomas Holmstrom, Mette Galsgaard Malle, Shunliang Wu, Knud Jorgen Jensen, Nikos S. Hatzakis, Christian Marcus Pedersen
Summary: This paper introduces a new lipid that can change its conformation based on the presence of Zn2+, triggered by the metal chelator Na(2)EDTA. The lipid was successfully incorporated into stable liposomes and showed potential for releasing the fluorescent cargo through a conformational change.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Margarida Ferreira-Silva, Catarina Faria-Silva, Pedro Viana Baptista, Eduarda Fernandes, Alexandra Ramos Fernandes, Maria Luisa Corvo
Summary: Rheumatoid arthritis is an autoimmune disease with available therapies, but there is a need for more effective treatments. Drug delivery systems like liposomes play a crucial role in treatment, but obstacles to successful clinical translation need to be addressed.
Review
Pharmacology & Pharmacy
Epiphane K. Silli, Mengfei Li, Yuting Shao, Yiran Zhang, Guilin Hou, Jiaqian Du, Jingdan Liang, Ying Wang
Summary: This review discusses the applications of liposomes in the treatment of pancreatic cancer. Pancreatic cancer is an incurable disease with a high death rate. By using different liposomal nanostructures, the effectiveness of chemotherapy drugs can be optimized and toxicity can be reduced.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Mah Noor Zafar, Waad H. Abuwatfa, Ghaleb A. Husseini
Summary: In order to improve current cancer treatments, nanomaterials are used as smart drug delivery vehicles that can be designed to specifically target cancer cells and respond to stimulation. These nanocarriers can encapsulate chemotherapy drugs and deliver them to the affected area, reducing the side effects associated with conventional systemic administration. Different sonosensitive liposomal formulations that can be stimulated using acoustic methods are discussed in this review. Emulsion liposomes (eLiposomes) are highlighted for their ability to promote drug release at low intensities and short exposure times compared to regular liposomes. Other formulations incorporating microbubbles and nanobubbles are also explored.
Article
Medicine, Research & Experimental
Guilherme S. Ramos, Virginia M. R. Vallejos, Marina S. Ladeira, Priscila G. Reis, Daniel M. Souza, Yuri A. Machado, Luiz O. Ladeira, Mauricio B. Pinheiro, Maria N. Melo, Ricardo T. Fujiwara, Frederic Frezard
Summary: The study found that fullerol has potential anti-leishmanial activity, especially when combined with liposomes, showing significant reduction in parasite load. This innovative approach provides a new potential method for treating VL.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Gustav Christensen, Leon Barut, Dileep Urimi, Nicolaas Schipper, Francois Paquet-Durand
Summary: This study demonstrated the feasibility of using fresh porcine eyes as a model for testing intravitreal biodistribution and retention of liposomes, providing insights into important considerations for ocular drug delivery. The results showed that PEG-coated liposomes were rapidly absorbed on the retina, while positively charged and PEG-coated liposomes were retained for at least 24 hours. Toxicity experiments on murine-derived retinal explant cultures indicated increased photoreceptor cell death at higher concentrations of anionic and cationic liposomes.
Review
Chemistry, Multidisciplinary
Milad Ashrafizadeh, Masoud Delfi, Ali Zarrabi, Ashkan Bigham, Esmaeel Sharifi, Navid Rabiee, Ana Claudia Paiva-Santos, Alan Prem Kumar, Shing Cheng Tan, Kiavash Hushmandi, Jun Ren, Ehsan Nazarzadeh Zare, Pooyan Makvandi
Summary: This review discusses the use of stimuli-responsive liposomes for targeted drug delivery in cancer therapy. These liposomes can be triggered by various stimuli such as pH, redox, enzymes, light, heat, and magnetic field to release drugs at tumor sites. The stimuli-responsive liposomes have shown great potential in improving the efficacy of anticancer drugs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Multidisciplinary
Cindy Schelker, Patrycja Nowak-Sliwinska, Gerrit Borchard
Summary: Fixed-drug combinations have been used for cancer treatment, but current therapies have limitations in terms of resistance and toxicity. The combination of tyrosine kinase inhibitors and histone deacetylase inhibitors is being investigated in clinical trials and has shown promising results. Utilizing appropriate drug delivery systems, such as nanocarriers, can further enhance the activity and specificity of drug combinations. Strategies for the delivery of synergistic drug combinations for cancer treatment are discussed in this review.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Plant Sciences
Jing-Jing Wu, Jia Zhang, Cong-Yuan Xia, Kang Ding, Xin-Xin Li, Xue-Ge Pan, Jie-Kun Xu, Jun He, Wei-Ku Zhang
Summary: This review provides a comprehensive summary and analysis of the extensive pharmacological applications of hypericin. By reviewing the literature, it presents conclusions on the natural and artificial sources of hypericin, strategies to improve its bioactivity, pharmacological activities, and drug combinations, and explores the future therapeutic potential of this active compound.
Review
Chemistry, Multidisciplinary
Xiamin Cheng, Jing Gao, Yang Ding, Yao Lu, Qiancheng Wei, Dezhi Cui, Jiali Fan, Xiaoman Li, Ershu Zhu, Yongna Lu, Qiong Wu, Lin Li, Wei Huang
Summary: This review discusses the development of liposomes as versatile nano-carriers for drug delivery in order to overcome limitations of PDT and enhance therapeutic effects.
Article
Chemistry, Multidisciplinary
Xue-Liang Liu, Xiao Dong, Si-Cong Yang, Xing Lai, Hai-Jun Liu, Yuhao Gao, Hai-Yi Feng, Mao-Hua Zhu, Yihang Yuan, Qin Lu, Jonathan F. Lovell, Hong-Zhuan Chen, Chao Fang
Summary: Nano-Pt loaded liposomal system enhances photodynamic therapy and chemotherapy in cancer treatment by increasing oxygen supply and releasing nanoparticles for better penetration, leading to inhibited tumor growth and extended survival without toxicity in animal models.
Review
Pharmacology & Pharmacy
Vivek Makwana, Jasmine Karanjia, Thomas Haselhorst, Shailendra Anoopkumar-Dukie, Santosh Rudrawar
Summary: Liposomal delivery systems have greatly improved the efficacy and safety of chemotherapeutic agents, particularly in the case of doxorubicin. Surface modification of liposomes, such as pegylation, can prolong drug circulation time and enhance drug accumulation in tumor tissue through passive targeting. Active targeting using biological ligands on the liposome surface shows potential for further improving tumor targeting efficiency in drug delivery systems.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Hasan H. Bahjat, Raid A. Ismail, Ghassan M. Sulaiman, Hamdoon A. Mohammed, Mohsen Al-Omar, Salman A. A. Mohammed, Riaz A. Khan
Summary: Iron oxide and titania-based composite nanoparticles with core-shell structures were synthesized using two-fluence LASER ablation technique. These nanoparticles showed antimicrobial and anti-lung cancer activities.
BIOINORGANIC CHEMISTRY AND APPLICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Hamdoon A. Mohammed, Riaz A. Khan
Summary: Anthocyanins, water-soluble colored compounds of the flavonoid class, are abundantly found in various parts of plants. They have been widely used for liver protection and as antioxidants, exhibiting various biological activities. The extraction and production methods of anthocyanin-based products are of great economic importance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Salman A. A. Mohammed, Khawla S. Khashan, Majid S. Jabir, Farah A. Abdulameer, Ghassan M. Sulaiman, Mohsen S. Al-Omar, Hamdoon A. Mohammed, Aseel A. Hadi, Riaz A. Khan
Summary: CuO NPs-decorated CNPs were synthesized using pulsed laser ablation technique in liquid medium, showing antimicrobial activity against S. aureus and E. coli, as well as anticancer activity against MCF-7 breast cancer cell line. The preparation method provided a cost-effective and eco-friendly approach for therapeutic applications.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Plant Sciences
Ehab M. Mostafa, Hamdoon A. Mohammed, Arafa Musa, Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Suliman A. Almahmoud, Mohammed M. Ghoneim, Hesham A. M. Gomaa, Fatema El-Zahraa S. Abdel Rahman, Khaled Shalaby, Samy Selim, Riaz A. Khan
Summary: The study isolated phenanthroindolizidine alkaloids from Tylophora indica and evaluated their anticancer activity. Among the isolated compounds, tylophorinidine (5) exhibited the highest cytotoxicity against three different cancer cell lines. Molecular docking studies confirmed the bioactivity of these compounds.
Article
Biochemistry & Molecular Biology
Zainab S. Abbas, Ghassan M. Sulaiman, Majid S. Jabir, Salman A. A. Mohammed, Riaz A. Khan, Hamdoon A. Mohammed, Amal Al-Subaiyel
Summary: The study evaluates a newly modified cyclodextrin derivative, water-soluble beta-cyclodextrin-epichlorohydrin (beta-CD), as a drug carrier to improve the solubility and bioavailability of galangin (GAL). In vitro tests showed that the GAL/beta-CD complex exhibited cytotoxic effects on cancer cells without affecting normal cells. In vivo experiments on mice demonstrated the lack of toxic effects on normal cells.
Article
Biochemistry & Molecular Biology
Zahraa A. Kadhim, Ghassan M. Sulaiman, Ahmed M. Al-Shammari, Riaz A. Khan, Osamah Al Rugaie, Hamdoon A. Mohammed
Summary: In this study, TMZ-loaded PLGA nanoparticles were prepared and co-administered with oncolytic Newcastle Disease Virus (NDV) for the treatment of GBM. The synergistic effects of the nano-formulation and viral strain combined therapy were observed on the cancer cell lines, demonstrating their potential for GBM treatment.
Review
Chemistry, Multidisciplinary
Naseem Akhtar, Hamdoon A. Mohammed, Mohammed Yusuf, Amal Al-Subaiyel, Ghassan M. Sulaiman, Riaz A. Khan
Summary: Considerable efforts have been made to develop nano-structured carriers, based on superparamagnetic iron oxide nanoparticles (SPIONs), for the delivery of the anticancer drug doxorubicin. These carriers have shown promise in overcoming the limitations of doxorubicin's toxicity, low therapeutic outcomes, inappropriate dosing, metastatic and general resistance, and non-selectivity. The development of SPIONs-based drug delivery modules allows for targeted and stable delivery of doxorubicin to different cancer sites, making it a viable option for cancer treatment.
Article
Chemistry, Multidisciplinary
Duaa R. Ibraheem, Nehia N. Hussein, Ghassan M. Sulaiman, Hamdoon A. Mohammed, Riaz A. Khan, Osamah Al Rugaie
Summary: In this study, silver nanoparticles (AgNPs) with antibacterial properties were successfully synthesized using the chemical reduction method, and the antibiotic ciprofloxacin (CIP) was loaded onto the AgNPs to enhance its antibacterial activity. The new nanocomposite, AgNPs-PEG-CIP, showed higher antibacterial, antibiofilm, and antioxidant activity against the tested pathogenic bacteria compared to CIP alone, indicating its potential as an antibacterial agent.
Article
Infectious Diseases
Amna M. M. Abdul-Jabbar, Nehia N. N. Hussian, Hamdoon A. A. Mohammed, Ahmed Aljarbou, Naseem Akhtar, Riaz A. A. Khan
Summary: Bacterial drug resistance to antibiotics is increasing globally, and scientists are continuously developing strategies to overcome this issue. In this study, the efficacy of combining silver nanoparticles and lincomycin antibiotic in combatting bacterial resistance was demonstrated. The combined delivery showed improved antibacterial activity compared to the individual use of silver nanoparticles and lincomycin in Bacillus cereus and Proteus mirabilis microorganisms. Additionally, the study found that silver nanoparticles exhibit strong antioxidant activity.
Article
Chemistry, Medicinal
Ahmed A. H. Abdellatif, Hamdoon A. Mohammed, Ali M. Al-Khalaf, Omar Khan, Mahmoud A. H. Mostafa, Rwaida A. Al Haidari, Hesham H. Taha, Riaz A. Khan
Summary: This study aimed to develop a cosmeceutical preparation using the strong antioxidant potential of Ginkgo biloba (GB) leaves. Cream incorporated GB (GBC) was prepared and characterized, showing stable physical and chemical properties with a pH similar to the skin. The cream showed effectiveness and safety, with antioxidant and rejuvenating effects on the skin during the two-week trial.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Review
Biochemistry & Molecular Biology
Hamdoon A. Mohammed, Abdul-Hamid Emwas, Riaz A. Khan
Summary: Halophytes and xerophytes, plants with strong tolerance to salinity and drought, have higher production of phenolics and flavonoids compared to normal vegetation. Due to increasing desertification and the associated challenges of high salinity, temperature, and water scarcity, these plants have become important for environmental protection, land reclamation, and food security. They also show potential in the development of newer cancer therapeutics, as they possess prophylactic properties and exhibit anti-cancer effects through their phytochemical and pharmacological properties, particularly immunomodulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Fatma A. Elshibani, Hamdoon A. Mohammed, Amr S. Abouzied, Abdulnaser Kh. Abdulkarim, Riaz A. Khan, Suliman A. Almahmoud, Bader Huwaimel, Abdullah D. Alamami
Summary: This article presents the first documented phytochemical and biological evaluation report of Thymbra linearifolia, an endemic Libyan plant. The study revealed the presence of phenolic and flavonoid compounds in the plant, which exhibited strong antioxidant and anticancer activities. Additionally, the plant also showed moderate antimicrobial effects.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Atiaf Rhyaf, Hala Naji, Hassan Al-Karagoly, Salim Albukhaty, Ghassan M. Sulaiman, Abdulaziz Arif A. Alshammari, Hamdoon A. Mohammed, Majid Jabir, Riaz A. Khan
Summary: Combining bovine serum albumin with microemulsions as a biopolymer ingredient is an innovative method for addressing surface functionalization and stability issues in targeted payload deliveries. The current study aimed to develop an efficient microemulsion system encapsulating sesame oil as a model payload for efficient delivery. Characterization and analysis of the developed carrier were performed using UV-VIS, FT-IR, and FE-SEM. Physicochemical properties of the microemulsion were assessed and analyzed using dynamic light scattering, zeta potential, electron microscopy, and rheological behavior. In vitro and in vivo assays were conducted to evaluate cell viability, biocompatibility, and toxicity.
Article
Biotechnology & Applied Microbiology
Ameer A. Imarah, Majid S. Jabir, Ali H. Abood, Ghassan M. Sulaiman, Salim Albukhaty, Hamdoon A. Mohammed, Riaz A. Khan, Hayder M. Al-Kuraishy, Ali Al-Gareeb, Waleed K. Al-Azzawi, Mazin A. Najm, Sabrean F. Jawad
Summary: In this study, the cytotoxic effects of graphene oxide nanoparticles (GONPs) were evaluated using MTT assays, observation of apoptotic markers, and oxidative stress. Significant cytotoxic and apoptotic effects were observed. Analyses of CYP2E1 and malondialdehyde concentrations confirmed the toxicity of GONPs, while the levels of glutathione showed a reduction compared to the control. The alterations in cytochrome CYP2E1, glutathione, malondialdehyde, and caspase-3 suggest an interlinked relationship.
Article
Chemistry, Multidisciplinary
Hamdoon A. Mohammed, Muhamad Abd-Elraouf, Ghassan M. Sulaiman, Suliman A. Almahmoud, Fatma A. Hamada, Riaz A. Khan, Mostafa M. Hegazy, Mohammed F. Abd-El-Wahab, Taha A. Kedra, Ahmed Ismail
Summary: Achillea millefolium Linn. is traditionally used for its medicinal properties and has economic value in cosmetic and insect repellent industries. The essential oils obtained from different parts of the plant were analyzed and investigated for their antioxidant and anticancer activities. The major constituents of the volatile oils varied among different batches of the plant, with monoterpenes being predominant in the distilled oils and sesquiterpenes in the non-polar extracts. The distilled batches exhibited better antioxidant activity, while the non-polar extracts showed remarkable cytotoxic effects against cancer cells.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Xin Zhang, Tian Yuan, Xuhui Chen, Xuebo Liu, Jun Hu, Zhigang Liu
Summary: The prevalence of Alzheimer's disease is increasing due to aging population, and ApoE4 allele is identified as the primary genetic risk factor. However, emerging research suggests that dietary factors, such as DHA, can modify the risk of AD. The interplay between DHA and ApoE genotype within the brain needs further investigation. Early DHA supplementation may benefit cognitively normal older adults carrying the ApoE4 gene, while its effectiveness for AD patients is limited.
PROGRESS IN LIPID RESEARCH
(2024)
Review
Biochemistry & Molecular Biology
Chen Wu, Haiqin Chen, Yongchao Mei, Bo Yang, Jianxin Zhao, Catherine Stanton, Wei Chen
Summary: This review summarizes the recent advances in microbial conjugated linoleic acid (CLA) production, including the mechanisms of linoleic acid conversion to CLA, factors influencing CLA production and isomer composition, and strategies for enhancing CLA content and nutritional value in fermented products using microorganisms. The review aims to serve as a reference for microbial CLA production and expand the understanding of the potential probiotic role of microbial CLA producers.
PROGRESS IN LIPID RESEARCH
(2024)