Article
Biochemistry & Molecular Biology
Silvia Voci, Cristina Pangua, Maria Cristina Martinez-Oharriz, Paula Aranaz, Maria Collantes, Juan M. Irache, Donato Cosco
Summary: The study characterizes Brij O2-stabilized gliadin nanoparticles for potential oral drug delivery. Physico-chemical evaluations and in vivo studies in rats and Caenorhabditis elegans confirmed the nanoparticles' ability to accumulate in the mucosa and move along the digestive system. The nanoparticles showed antioxidant activity, decreased age-related lipofuscin pigment, and demonstrated a safe profile. These findings support the future application of these nanoparticles for oral delivery of bioactives.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Rouheena Shakir, Sana Hanif, Ahmad Salawi, Rabia Arshad, Rai Muhammad Sarfraz, Muhammad Irfan, Syed Atif Raza, Kashif Barkat, Fahad Y. Sabei, Yosif Almoshari, Meshal Alshamrani, Muhammad Ali Syed
Summary: The aim of this study was to develop a buccal delivery system with mucoadhesive properties for sustained release of metformin and sitagliptin in the treatment of diabetes mellitus. The use of Carbopol 940, agarose, and polyvinylpyrrolidone K30 as mucoadhesive agents in tablet formulations resulted in favorable mucoadhesive properties. Formulation R4 showed complete drug release within 6 hours, with a mucoadhesive strength of 26.99 g and a mucoadhesive time of 8.1 h in ex vivo studies. The CP and PVP blend demonstrated stability for up to 6 months. Overall, the CP and PVP blend was found to be appropriate for achieving the desired release and mucoadhesive properties in buccal tablets.
Article
Biophysics
Ankit Javia, Ambikanandan Misra, Hetal Thakkar
Summary: DPK-060 is a synthetic peptide derived from human protein kininogen, which exhibits strong antimicrobial and anti-inflammatory activities. It has shown potential in the treatment of atopic dermatitis (AD), and the nanostructured lipid-based gel formulation of DPK-060 has demonstrated controlled release and improved permeation compared to conventional formulations. This study confirms the efficacy of DPK-060 NLC gel as a safe and novel alternative for AD treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Polymer Science
K. Reeta Vijaya Rani, Sruthi Rajan, Mullaicharam Bhupathyraaj, R. Krishna Priya, Nirmala Halligudi, Mohammad Abobakr Al-Ghazali, Sathvik B. Sridhar, Javedh Shareef, Sabin Thomas, Saleem M. Desai, Pandurang D. Pol
Summary: A novel ophthalmic pH-induced nanoemulsion in situ gel of Timolol maleate (NEI5) was developed in this study, which demonstrated continuous drug release and decreased intraocular pressure (IOP) in glaucoma patients.
Article
Pharmacology & Pharmacy
Mohamed M. Badran, Nadia N. Alouny, Basmah N. Aldosari, Ahlam M. Alhusaini, Amal El Sayeh Abou El Ela
Summary: The study developed a sustained-release transdermal GLP film using chitosan-coated deformable liposomes (DLs) to overcome the challenges associated with oral administration of the drug. The DLs showed improved drug transdermal delivery compared to conventional liposomes (CL), with high stability and deformability. The in vitro release study confirmed sustained release of GLP, and coating with CS further enhanced the sustained release. The transdermal films demonstrated promising pharmacokinetic profiles and higher hypoglycemic effect compared to oral GLP, indicating the potential of systemic action through local topical delivery.
Article
Polymer Science
Miroslava Spaglova, Martina Papadakos, Maria Cuchorova, Desana Matusova
Summary: This study aimed to evaluate the effect of reference microemulsion and lecithin-containing microemulsion on the release of tretinoin and its retention in the skin. The results showed that microemulsion-Carbopol gel formulations exhibited better performance in tretinoin release and skin retention.
Article
Polymer Science
Kamran Ahmad Khan, Claudia Zizzadoro, Alessandro Di Cerbo, Nicola Pugliese, Gul Majid Khan, Shakira Ghazanfar, Eman M. Almusalami, Muhammad Muzammal, Khaled J. Alsalman, Arshad Farid
Summary: Controlled-release formulations are important for drugs that require adjustment of their activity to maximize therapeutic effects and minimize adverse reactions. This study evaluated the effects of Ethocel grade 10 and Carbopol 934P NF on the release of losartan potassium and found that they exhibited good flow and physical properties at appropriate drug/polymer ratios and with the addition of co-excipients. The release profiles of these controlled-release formulations were significantly different from that of a traditional losartan formulation.
Article
Medicine, Research & Experimental
Adrian Rump, Carolin Tetyczka, Eva Littringer, Marie-Luise Kromrey, Robin Buelow, Eva Roblegg, Werner Weitschies, Michael Grimm
Summary: Gastroretentive dosage forms, which can release drugs inside the stomach for a prolonged period, offer advantages such as improved pharmacokinetics/bioavailability and reduced intake frequency, leading to better patient adherence. However, there are currently no gastroretentive products with proven efficacy in humans. One effective approach is the use of mucoadhesive properties to prevent gastric emptying. The adhesion time of minitablets containing Carbopol 71G NF was significantly longer compared to non-adhesive minitablets, resulting in delayed gastric emptying. However, further improvement is needed to achieve clinical benefits, and variations in gastric residence time were observed.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Alessandra R. Freitas, Antonio J. Ribeiro, Alessandra B. Ribeiro, Maria Del Mar Collado-Gonzalez, Luis R. Silva, Luis Alves, Elodie Melro, Filipe E. Antunes, Francisco Veiga, Alan I. S. Morais, Roosevelt D. S. Bezerra, Jose L. Soares-Sobrinho, Josy A. Osajima, Edson C. Silva-Filho
Summary: The present work aimed to modify the exuded gum of Sterculia striata tree through an amination reaction. The viscosity and zero potential of the chicha gum varied with pH. The modification was confirmed by various analytical techniques, and the modified gum showed increased mucoadhesive and inhibitory activity against Staphylococcus aureus, as well as antioxidant capacity and inhibitory effect against alpha-glucosidase.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Ayesha Mahmood, Asif Mahmood, Mohamed A. Ibrahim, Zahid Hussain, Muhammad Umar Ashraf, Mounir M. Salem-Bekhit, Ibrahim Elbagory
Summary: This research aimed to develop a pH-responsive polymeric system for targeted drug delivery of Diloxanide furoate. Sodium alginate (Na-Alg) and Carbopol 934P were used as building blocks and SCH1-SCH12 were created with different polymer ratios. Positive outcomes were observed in swelling and release profiles at higher pH levels. Hydrogel formation, component compatibility, thermal stability, and Diloxanide furoate loading were all validated. The results showed the potential of this polymeric system for pH-dependent localized and regulated drug delivery.
Article
Biochemistry & Molecular Biology
Ahmed Alzainy, Joshua Boateng
Summary: This research aimed to develop, characterize, and optimize freeze-dried wafers loaded with metronidazole (MTz) to treat vaginal bacterial infections. The study improved the physico-chemical properties of the wafer formulations and successfully achieved sustained drug release and antimicrobial activity, demonstrating potential clinical applications.
Article
Engineering, Biomedical
Patrick Knoll, Nguyet-Minh Nguyen Le, Richard Wibel, Randi Angela Baus, Gergely Kali, Mulazim Hussain Asim, Andreas Bernkop-Schnuerch
Summary: Three generations of thiolated polymers have been developed with different thiol ligands to enhance mucus interactions. This study synthesized all three generations on a pectin backbone for the first time, with third generation showing superior mucoadhesive properties. Additionally, the polymers did not exhibit cytotoxicity, indicating potential applications in drug delivery systems.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Chemical
Aseel Abu-Rumman, Rana Abu-Huwaij, Rania Hamed
Summary: Atorvastatin (ATR) is often prescribed to lower plasma cholesterol levels. However, its oral use is hindered by its poor solubility, high protein binding, and low bioavailability. In this study, mucoadhesive patches for buccal delivery of ATR were developed using Carbopol as a mucoadhesive polymer, Soluplus as a water-solubilizer carrier, and ethylene/vinyl acetate as a backing layer. The optimized patch formulation showed good flexibility, uniform thickness, weight, and drug content. It exhibited positive mucoadhesion properties, appropriate surface pH, and swelling level. The drug permeation was significantly increased compared to the reference patch, suggesting that the micellar structures of Soluplus solubilized ATR and controlled its release across the mucoadhesive Carbopol network.
JOURNAL OF ADHESION
(2022)
Article
Pharmacology & Pharmacy
Paula de Freitas Rosa Remiro, Mariana Harue Taniguchi Nagahara, Martina Ghezzi, Alessia Filippini, Anna Demurtas, Silvia Pescina, Patrizia Santi, Cristina Padula, Angela Maria Moraes, Sara Nicoli
Summary: This study developed buccal formulations for topical administration of imiquimod, aiming to improve mucosal retention and reduce trans-mucosal permeation compared to the reference formulation. The developed hydrogels and films showed comparable in vitro performance to the commercial formulation, with significantly reduced permeation in the case of the xanthan gum film.
Article
Biochemistry & Molecular Biology
Muhammad Ali Syed, Sana Hanif, Noor ul Ain, Haroon Khalid Syed, Ameer Fawad Zahoor, Ikram Ullah Khan, Walaa A. Abualsunun, Abdulmajeed M. Jali, Safa H. Qahl, Muhammad H. Sultan, Osama A. Madkhali, Rayan A. Ahmed, Nasir Abbas, Amjad Hussain, Muhammad Abdul Qayyum, Muhammad Irfan
Summary: This study evaluates the mucoadhesive potential of AG binary dispersions with Carbopol 934P as gel preparations. The results show that the mucoadhesive properties of AG are concentration dependent and can be improved by the addition of CP. The optimized formulation (F9) exhibits the highest mucoadhesive strength and swelling index.
Review
Ophthalmology
Arpita Bhattacharjee, Pranab J. Das, Piya Adhikari, Daphisha Marbaniang, Paulami Pal, Subhabrata Ray, Bhaskar Mazumder
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2019)
Review
Food Science & Technology
Madhavi Gupta, Sanjay Dey, Daphisha Marbaniang, Paulami Pal, Subhabrata Ray, Bhaskar Mazumder
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2020)
Article
Chemistry, Applied
Hriday Bera, Yasir Faraz Abbasi, Law Lee Ping, Daphisha Marbaniang, Bhaskar Mazumder, Pramod Kumar, Prajakta Tambe, Virendra Gajbhiye, Dongmei Cun, Mingshi Yang
CARBOHYDRATE POLYMERS
(2020)
Article
Chemistry, Physical
Arpita Bhattacharjee, Pranab J. Das, Sanjay Dey, Amit Kumar Nayak, Probin Kr. Roy, Srijita Chakrabarti, Daphisha Marbaniang, Sanjoy Kumar Das, Subhabrata Ray, Pronobesh Chattopadhyay, Bhaskar Mazumder
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2020)
Article
Pharmacology & Pharmacy
Prakash Rajak, Lila Kanta Nath, Bhaskar Mazumder
Summary: The pH-sensitive Lyotropic liquid crystals (LLC) can flip their structure according to different pH environments, facilitating colon-targeted release of 5-FU. The formulation containing 40% MO and 60% OA showed the best drug release performance in the colon and rectum pH conditions, with slow and extended release over longer periods of time.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2021)
Review
Biology
Kumud Joshi, Danswrang Goyary, Bhaskar Mazumder, Pronobesh Chattopadhyay, Reshmi Chakraborty, Y. D. Bhutia, Sanjeev Karmakar, Sanjai Kumar Dwivedi
JOURNAL OF THERMAL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Srijita Chakrabarti, Bhaskar Mazumder, Jadab Rajkonwar, Manash Pratim Pathak, Pompy Patowary, Pronobesh Chattopadhyay
Summary: Hydrogels are considered an important delivery system for wound treatment, with the study showing that bFGF-collagen-AgSD incorporated hydrogel formulation can accelerate burn healing and promote fibroblast cell proliferation. The developed hydrogel significantly accelerated wound closure by increasing re-epithelialization and granulation tissue formation, indicating its potential as a promising delivery system against second degree burns.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Vipin Kumar Sharma, Prince Prashant Sharma, Bhaskar Mazumder, Aseem Bhatnagar, Vetriselvan Subramaniyan, Shivkanya Fuloria, Neeraj Kumar Fuloria
Summary: This study developed mucoadhesive microspheres using Isabgol husk mucilage as a polymeric backbone for sustained release of gliclazide. The microspheres showed prolonged retention in the gastrointestinal tract of rabbits for up to 24 hours, indicating their potential rationality in controlling hyperglycemia in diabetes.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Chemistry, Medicinal
Kumud Joshi, Bhaskar Mazumder, Pronobesh Chattopadhyay, Danswrang Goyary, Madhubanti Das, Sanjai Kumar Dwivedi
Summary: The study developed a hydrogel formulation for frostbite healing using Manuka honey and hyaluronic acid, showing significant antimicrobial and antithrombotic properties. It promotes wound contraction and complete healing, potentially acting through the VEGF-NRF-2 pathway.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Nursing
Nongmaithem Randhoni Chanu, Kunal Bhattacharya, Daphisha Marbaniang, Paulami Pal, Subhabrata Ray, Bhaskar Mazumder
Summary: The study aimed to formulate and study the characteristics of a gelation-based melatonin sponge crosslinked with fructose for wound healing application. The results showed that the formulated sponge had good mechanical properties, water uptake, and water retention capacities. Animal experiments demonstrated that wounds covered by the gelatin loaded with a melatonin sponge healed quickly.
JOURNAL OF VASCULAR NURSING
(2022)
Retraction
Pharmacology & Pharmacy
Nilutpal Sharma Bora, Bhaskar Mazumder, Santa Mandal, Pompy Patowary, Danswrang Goyary, Pronobesh Chattopadhyay, Sanjai Kumar Dwivedi
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Chemistry, Medicinal
Daphisha Marbaniang, Anup Kumar Das, Paulami Pal, Niva Rani Gogoi, Ananta Saikia, Subhabrata Ray, Bhaskar Mazumder
Summary: Boswellic acids are pentacyclic triterpenes derived from Boswellia serrata trees, known as Indian Frankincense, and traditionally used as an anti-inflammatory agent. They have various pharmacological potentials like anti-inflammatory, anti-cancer, anti-microbial, anti-arthritic, immunomodulatory activity, neuroprotective activity, and are effective against ileitis, ulcerative colitis, hypolipidemic, hypertension and hepatotoxicity. However, their poor oral bioavailability and high lipophilicity have led to the development of novel delivery systems to improve their pharmacokinetic profile.
NATURAL PRODUCTS JOURNAL
(2023)
Review
Integrative & Complementary Medicine
Ratna Jyoti Das, Kalyani Pathak, Smita Bordoloi, Riya Saikia, Saif Aboud Alqahtani, Jon Saharia, Mary Devi, Bhaskar Mazumder
Summary: This article summarizes the ethnopharmacology, pharmacological properties, and phytochemistry of Clerodendrum colebrookianum Walp. The research suggests that this plant has the potential to treat hypertension, diabetes, and other chronic diseases.
CURRENT TRADITIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Vipin Kumar, Bhaskar Mazumder, Prince Prashant Sharma, Yusra Ahmed
Summary: The study found that the hypoglycemic effect and bioavailability of gliclazide loaded in Isabgol husk microparticles were better than pure gliclazide, suggesting the potential of microparticulate formulation as a novel anti-diabetic drug delivery system.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2021)
Article
Chemistry, Medicinal
Vipin Kumar Sharma, Bhaskar Mazumder, Vinod Nautiyal, Prince Prashant Sharma, Yusra Ahmed
NATURAL PRODUCTS JOURNAL
(2019)