Article
Virology
Behdokht Jan Fada, Udayan Guha, Yi Zheng, Eleazar Reward, Elie Kaadi, Ayette Dourra, Haidong Gu
Summary: It was found that ICP0 E3 enzyme continuously degrades PML I through a specific mechanism to prevent the reformation of ND10 complex.
Article
Microbiology
Tejaswini S. Reddi, Philipp E. Merkl, So-Yon Lim, Norman L. Letvin, David M. Knipe
Summary: TRIM22 is a novel restriction factor that can combat DNA viruses, particularly HSV-1, and is not degraded by viral ICP0 protein. It also inhibits other types of herpesviruses and different genetic variants of TRIM22 show varying levels of effectiveness against HSV-1.
Article
Multidisciplinary Sciences
Liangqian Huang, Trisha Agrawal, Guixin Zhu, Sixiang Yu, Liming Tao, JiaBei Lin, Ronen Marmorstein, James Shorter, Xiaolu Yang
Summary: Protein quality control systems are crucial for cellular function and organismal health. Recent studies have shown that polyD/E proteins, such as DAXX, ANP32A, and SET, may constitute a multifunctional protein quality control system that operates via a distinctive mechanism without relying on ATP.
Review
Immunology
Mila Collados Rodriguez
Summary: Sp100 gene expression restricts virus replication and can be further enhanced by interferon stimulation. Different Sp100 isoforms are involved in chromatin transcription regulation and antiviral defense. Virus protein antagonists can relieve the restriction imposed by Sp100 and other proteins in certain viral infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medical Laboratory Technology
Troy D. Jaskowski, Vijayalakshmi Nandakumar, Camille L. Novis, Michael Palmer, Anne E. Tebo
Summary: This study aimed to determine the additional value of anti-sp100 or anti-gp210 antibody in AMA-positive patients. It found that the frequencies of these antibodies were higher in AMA-positive patients, and these patients were more likely to be diagnosed with primary biliary cholangitis (PBC). The use of all tests may improve the characterization of at-risk patients for PBC.
CLINICA CHIMICA ACTA
(2023)
Review
Oncology
Alexandros Pergaris, Ioannis Genaris, Ioanna E. Stergiou, Jerzy Klijanienko, Stavros P. Papadakos, Stamatios Theocharis
Summary: DAXX and HJURP are proteins involved in many physiological processes and have been implicated in the development of various tumors. This review summarizes studies investigating the expression of these proteins in different tumor types and highlights their role as potential biomarkers for diagnosis and prognosis in cancer.
Article
Microbiology
Mirna Perusina Lanfranca, Jessica M. van Loben Sels, Cindy Y. Ly, Tristan R. Grams, Adit Dhummakupt, David C. Bloom, David J. Davido
Summary: Herpes simplex virus 1 (HSV-1) utilizes the viral E3 ubiquitin ligase, ICP0, to counteract the antiviral effects of interferon (IFN)-beta by altering the cellular signaling and gene expression. A specific 77 amino acid region in the N-terminal half of ICP0 facilitates HSV-1's resistance to IFN-beta and may interact with the posttranslational modification SUMO.
MICROBIOLOGY SPECTRUM
(2022)
Article
Multidisciplinary Sciences
Nitish Gulve, Chenhe Su, Zhong Deng, Samantha S. Soldan, Olga Vladimirova, Jayamanna Wickramasinghe, Hongwu Zheng, Andrew V. Kossenkov, Paul. M. Lieberman
Summary: The tumor suppressor proteins DAXX and ATRX play a critical role in regulating p53 chromatin accessibility and DNA damage response in cancers with alternative lengthening of telomeres (ALT). Disruption of this pathway is essential for the survival of ALT cells.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Fujun Hou, Zeyu Sun, Yue Deng, Siyu Chen, Xiyuan Yang, Feiyang Ji, Menghao Zhou, Keyi Ren, Dongli Pan
Summary: This study investigates the targets of ICP0 in HSV-1 infection and its roles in neuronal cells. Mass spectrometry analysis identified various proteins interacting with ICP0 in Neuro-2a and 293T cells. Further experiments confirmed that SNX9 and OTUD4 restrict the replication of ICP0-null virus in neuronal cells, and OTUD4 enhances the expression of type I interferon during infection with ICP0-null virus.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Cell Biology
Chang Sun, Yuan Qi, Natalie Fowlkes, Nina Lazic, Xiaoping Su, Guillermina Lozano, Amanda R. Wasylishen
Summary: Daxx functions as a histone chaperone for the histone H3 variant H3.3 and is essential for embryonic development. It interacts with Atrx to deposit H3.3 into heterochromatin, and this interaction is dispensable for viability. However, the interaction between Daxx and H3.3 is essential for postnatal viability and is important for silencing endogenous retroviruses and maintaining proper immune cell composition.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Yen-Sung Huang, Chang-Chieh Wu, Che-Chang Chang, Shiu-Feng Huang, Hong-Yi Kuo, Hsiu-Ming Shih
Summary: Upregulation of Daxx is associated with colorectal cancer, and it can promote CRC cell growth by activating PIK3CA.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Isabelle Trier, Elizabeth M. Black, Yoon Ki Joo, Lilian Kabeche
Summary: We have found that ATR kinase, a master regulator of the DNA damage response, protects CENP-A protein occupancy at centromeres during interphase independent of DNA damage. Furthermore, ATR-dependent phosphorylation of DAXX protein regulates CENP-A occupancy at centromeres and DAXX localization. Lastly, acute ATR inhibition during interphase leads to kinetochore formation defects and an increased rate of lagging chromosomes. These findings highlight a mechanism by which ATR protects centromere identity and genome stability.
Article
Microbiology
Yifei Liao, Blanca Lupiani, Sanjay M. Reddy
Summary: The study reveals that MDV US3 disrupts PML and SP100 in a kinase dependent manner, and a proteasome dependent degradation pathway is involved in this disruption process. These findings provide the first evidence for the interplay between MDV proteins and PML-NBs.
Review
Endocrinology & Metabolism
Fei Wang, Xiaowu Xu, Zeng Ye, Yi Qin, Xianjun Yu, Shunrong Ji
Summary: This study is the first rigorous pooled analysis assessing ATRX/DAXX mutations as prognostic biomarkers in PanNETs. The results indicate that patients with altered ATRX/DAXX genes have poor DFS, while altered ATRX/DAXX genes in metastatic patients show a trend towards improved overall survival.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Virology
Hope Waisner, Sarah Lasnier, Sreenath Muraleedharan Suma, Maria Kalamvoki
Summary: HSV-1 infection stimulates the production of extracellular vesicles (EVs) through the CD63 biogenesis pathway, which activate antiviral responses in recipient cells. The viral proteins ICP0 and ICP34.5 play a role in blocking autophagy, and the Delta ICP34.5 virus induces a greater release of EVs compared to the Delta ICP0 virus.
JOURNAL OF VIROLOGY
(2023)