Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8

Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis

(2015) Takumi Kiwamoto et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells

(2015) Yi Jia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Uncovering Nonconventional and Conventional Hydrogen Bonds in Oligosaccharides through NMR Experiments and Molecular Modeling: Application to Sialyl Lewis-X

(2015) Marcos D. Battistel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Eosinophils in mucosal immune responses

(2015) J Travers et al.   Mucosal Immunology

Functional Siglec lectin domains from soluble expression in the cytoplasm of Escherichia coli

(2015) Johannes M. Pröpster et al.   PROTEIN EXPRESSION AND PURIFICATION

Eosinophil Apoptosis as a Therapeutic Target in Allergic Asthma

(2013) Pinja Ilmarinen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Mechanism of Siglec-8–mediated cell death in IL-5–activated eosinophils: Role for reactive oxygen species–enhanced MEK/ERK activation

(2013) Gen Kano et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mice deficient in the St3gal3 gene product α2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation

(2013) Takumi Kiwamoto et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Galactose 6-O-Sulfotransferases Are Not Required for the Generation of Siglec-F Ligands in Leukocytes or Lung Tissue

(2013) Michael L. Patnode et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization of Branched Oligosaccharides: Lewisx Benefits from a Nonconventional C–H···O Hydrogen Bond

(2013) Mirko Zierke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Global Comparisons of Lectin–Glycan Interactions Using a Database of Analyzed Glycan Array Data

(2013) Doron Kletter et al.   MOLECULAR & CELLULAR PROTEOMICS

Targeting eosinophils in allergy, inflammation and beyond

(2013) Patricia C. Fulkerson et al.   NATURE REVIEWS DRUG DISCOVERY

Using chemical shift perturbation to characterise ligand binding

(2013) Mike P. Williamson   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

The role of lung epithelial ligands for Siglec-8 and Siglec-F in eosinophilic inflammation

(2012) Takumi Kiwamoto et al.   Current Opinion in Allergy and Clinical Immunology

Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions

(2012) Takumi Kiwamoto et al.   PHARMACOLOGY & THERAPEUTICS

IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils

(2011) Ho Jeong Na et al.   CYTOKINE

Expression of the carbohydrate recognition domain of FimH and development of a competitive binding assay

(2010) Said Rabbani et al.   ANALYTICAL BIOCHEMISTRY

Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma

(2010) Pei-Song Gao et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The many paths to asthma: phenotype shaped by innate and adaptive immunity

(2010) Hye Young Kim et al.   NATURE IMMUNOLOGY

ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids

(2010) H. Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

Structure determination and dynamics of protein–RNA complexes by NMR spectroscopy

(2010) Cyril Dominguez et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Structural insights into what glycan arrays tell us about how glycan-binding proteins interact with their ligands

(2009) Maureen E Taylor et al.   GLYCOBIOLOGY

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Eosinophil-Selective Binding and Proapoptotic Effect in Vitro of a Synthetic Siglec-8 Ligand, Polymeric 6'-Sulfated Sialyl Lewis X

(2009) S. A. Hudson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Siglecs as targets for therapy in immune-cell-mediated disease

(2009) Mary K. O’Reilly et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sialic acids in human health and disease

(2008) Ajit Varki   TRENDS IN MOLECULAR MEDICINE

Interleukin-5 Priming of Human Eosinophils Alters Siglec-8–Mediated Apoptosis Pathways

(2007) Esra Nutku-Bilir et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhibition of FcεRI-dependent mediator release and calcium flux from human mast cells by sialic acid–binding immunoglobulin-like lectin 8 engagement

(2007) Hidenori Yokoi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structural Implications of Siglec-5-Mediated Sialoglycan Recognition

(2007) Marina A. Zhuravleva et al.   JOURNAL OF MOLECULAR BIOLOGY