Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2

LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency

(2016) Jin Zhang et al.   Cell Stem Cell

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs

(2016) Robert A.J. Signer et al.   GENES & DEVELOPMENT

Stem cell function and stress response are controlled by protein synthesis

(2016) Sandra Blanco et al.   NATURE

Tunable protein synthesis by transcript isoforms in human cells

(2016) Stephen N Floor et al.   eLife

Yin-Yang 1 and Yin-Yang 2 exert opposing effects on the promoter activity of interleukin 4

(2015) Sung Ho Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

(2015) J. Pelletier et al.   CANCER RESEARCH

Critical role of YY1 in cardiac morphogenesis

(2015) Ilimbek Beketaev et al.   DEVELOPMENTAL DYNAMICS

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

An alternative splicing event amplifies evolutionary differences between vertebrates

(2015) S. Gueroussov et al.   SCIENCE

Transcription factor trapping by RNA in gene regulatory elements

(2015) A. A. Sigova et al.   SCIENCE

The human transcriptome across tissues and individuals

(2015) M. Mele et al.   SCIENCE

Alternative mRNA transcription, processing, and translation: insights from RNA sequencing

(2015) Eleonora de Klerk et al.   TRENDS IN GENETICS

The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation

(2015) Anthony J Linares et al.   eLife

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Multifaceted Regulation of Somatic Cell Reprogramming by mRNA Translational Control

(2014) Soroush Tahmasebi et al.   Cell Stem Cell

Genetic Exploration of the Exit from Self-Renewal Using Haploid Embryonic Stem Cells

(2014) Martin Leeb et al.   Cell Stem Cell

Widespread intron retention in mammals functionally tunes transcriptomes

(2014) Ulrich Braunschweig et al.   GENOME RESEARCH

Haematopoietic stem cells require a highly regulated protein synthesis rate

(2014) Robert A. J. Signer et al.   NATURE

RBPmap: a web server for mapping binding sites of RNA-binding proteins

(2014) Inbal Paz et al.   NUCLEIC ACIDS RESEARCH

The translational landscape of the splicing factor SRSF1 and its role in mitosis

(2014) Magdalena M Maslon et al.   eLife

Assessing gene-level translational control from ribosome profiling

(2013) Adam B. Olshen et al.   BIOINFORMATICS

Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation

(2013) Justin J.-L. Wong et al.   CELL

Essential and Unexpected Role of Yin Yang 1 to Promote Mesodermal Cardiac Differentiation

(2013) Serge Gregoire et al.   CIRCULATION RESEARCH

Frac-seq reveals isoform-specific recruitment to polyribosomes

(2013) T. Sterne-Weiler et al.   GENOME RESEARCH

MBNL proteins repress ES-cell-specific alternative splicing and reprogramming

(2013) Hong Han et al.   NATURE

mTORC1 Targets the Translational Repressor 4E-BP2, but Not S6 Kinase 1/2, to Regulate Neural Stem Cell Self-Renewal In Vivo

(2013) Nathaniel W. Hartman et al.   Cell Reports

Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention

(2012) K. Yap et al.   GENES & DEVELOPMENT

Chromatin-modifying enzymes as modulators of reprogramming

(2012) Tamer T. Onder et al.   NATURE

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments

(2012) Nicholas T Ingolia et al.   Nature Protocols

Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells

(2012) Pietro Vella et al.   NUCLEIC ACIDS RESEARCH

The Evolutionary Landscape of Alternative Splicing in Vertebrate Species

(2012) N. L. Barbosa-Morais et al.   SCIENCE

Single-vector inducible lentiviral RNAi system for oncology target validation

(2011) Dmitri Wiederschain et al.   CELL CYCLE

PTBP1 Is Required for Embryonic Development before Gastrulation

(2011) Jakob Suckale et al.   PLoS One

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Genome-wide analysis of YY2 versus YY1 target genes

(2010) Li Chen et al.   NUCLEIC ACIDS RESEARCH

It is not necessarily YY1--the frequently forgotten Yin-Yang-2 transcription factor

(2010) M. Klar   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

(2010) R. J. O. Dowling et al.   SCIENCE

Genome-wide analysis of mRNA decay patterns during early Drosophila development

(2010) Stefan Thomsen et al.   GENOME BIOLOGY

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Naive and Primed Pluripotent States

(2009) Jennifer Nichols et al.   Cell Stem Cell

Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation

(2009) Masaki Shibayama et al.   FEBS Journal

Evolutionary Origin and Functions of Retrogene Introns

(2009) M. Fablet et al.   MOLECULAR BIOLOGY AND EVOLUTION

Systems-level dynamic analyses of fate change in murine embryonic stem cells

(2009) Rong Lu et al.   NATURE

MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1

(2009) Yoshihiro Kino et al.   NUCLEIC ACIDS RESEARCH

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

A Hierarchical Network Controls Protein Translation during Murine Embryonic Stem Cell Self-Renewal and Differentiation

(2008) Prabha Sampath et al.   Cell Stem Cell

Translational control of the innate immune response through IRF-7

(2008) Rodney Colina et al.   NATURE

Small Increases in the Level of Sox2 Trigger the Differentiation of Mouse Embryonic Stem Cells

(2008) Janel L. Kopp et al.   STEM CELLS

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY