Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 113, Issue 34, Pages 9629-9634Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1606792113
Keywords
striatal projection neuron; dopamine; Parkinson's disease; basal ganglia; electrophysiology
Categories
Funding
- NIH [NS045962, NS073994]
- National Center for Research Resources [RR000165]
- Office of Research Infrastructure Programs/Office of the Director [OD011132]
- Plan Nacional, Ministerio de Economia y Competitividad [SAF2012-40216, SAF2015-67239-P]
- American Parkinson's Disease Association Advanced Center for Research
Ask authors/readers for more resources
Circuitry models of Parkinson's disease (PD) are based on striatal dopamine loss and aberrant striatal inputs into the basal ganglia network. However, extrastriatal mechanisms have increasingly been the focus of attention, whereas the status of striatal discharges in the parkinsonian human brain remains conjectural. We now report the activity pattern of striatal projection neurons (SPNs) in patients with PD undergoing deep brain stimulation surgery, compared with patients with essential tremor (ET) and isolated dystonia (ID). The SPN activity in ET was very low (2.1 +/- 0.1 Hz) and reminiscent of that found in normal animals. In contrast, SPNs in PD fired at much higher frequency (30.2 +/- 1.2 Hz) and with abundant spike bursts. The difference between PD and ET was reproduced between 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated and normal nonhuman primates. The SPN activity was also increased in ID, but to a lower level compared with the hyperactivity observed in PD. These results provide direct evidence that the striatum contributes significantly altered signals to the network in patients with PD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available