Article
Endocrinology & Metabolism
Junfeng Zhou, Yong Long, Ning Ding, Yingjie Su
Summary: This study found a positive association between later bedtime and nonalcoholic fatty liver disease (NAFLD), particularly on weekends. The relationship between bedtime and NAFLD varied across different time periods and different definitions of CAP score.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Hangkai Huang, Jiarong Xie, Yan Zeng, Zhening Liu, Min Miao, Lei Xu, Chengfu Xu
Summary: This study aimed to explore the association between serum remnant cholesterol and the development of nonalcoholic fatty liver disease (NAFLD). The results showed a positive correlation between high serum remnant cholesterol levels and increased risk of NAFLD, which remained significant even among individuals with normal levels of LDL-C, HDL-C, and triglycerides.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Jung Il Lee, Hyun Woong Lee, Kwan Sik Lee, Hye Sun Lee, Ju-Young Park
Summary: The study found that the use of statins can reduce the risk of NAFLD development and liver fibrosis.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Environmental Sciences
Shuilin Zheng, Yue Yang, Cong Wen, Wenya Liu, Linghui Cao, Xiangling Feng, Jihua Chen, Hui Wang, Yan Tang, Li Tian, Xiaoyan Wang, Fei Yang
Summary: The global prevalence of nonalcoholic fatty liver disease (NAFLD) is rapidly increasing, with environmental chemical contaminants being considered as tangible environmental risk factors for NAFLD.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Gastroenterology & Hepatology
Richie Manikat, Mindie H. Nguyen
Summary: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by excess fat accumulation in the liver. It is associated with metabolic syndrome and often presents with comorbidities such as obesity, type 2 diabetes mellitus, and dyslipidemia. NAFLD is also linked to non-liver comorbidities including cardiovascular disease, chronic kidney disease, and sleep apnea. Managing these comorbidities is crucial for improving liver-related and overall health outcomes in patients with NAFLD.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Seoung-Woo Lee, Young-Jin Lee, Su-Min Baek, Kyung-Ku Kang, Tae-Un Kim, Jae-Hyuk Yim, Hee-Yeon Kim, Se-Hyeon Han, Seong-Kyoon Choi, Sang-Joon Park, Tae-Hwan Kim, Jin-Kyu Park
Summary: Vitamin C treatment plays an important role in nonalcoholic fatty liver disease by suppressing disease progression through decreased diet ingestion and increased water intake.
Review
Pharmacology & Pharmacy
Jing Zhang, Quansheng Feng
Summary: Astragalus polysaccharides (APS), a chemical molecule derived from Astragalus membranaceus, have shown potential therapeutic effects on nonalcoholic fatty liver disease (NAFLD). APS may help slow the progression of NAFLD through multiple molecular pathways. However, further research and clinical evidence are still needed.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Wenhui Zhang, Ren Lang
Summary: NAFLD and NASH are significant contributors to liver disease worldwide. Macrophages play a crucial role in the pathogenesis of NAFLD and NASH, and their metabolic characteristics influence their activation state and functionality. Targeting macrophage metabolism could be a promising therapeutic approach for the management of NAFLD/NASH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Dong Hyun Sinn, Danbee Kang, Sung Chul Choi, Yun Soo Hong, Di Zhao, Eliseo Guallar, Yewan Park, Juhee Cho, Geum-Youn Gwak
Summary: The clinical implications of nonalcoholic fatty liver disease (NAFLD) in subjects who fulfill the diagnostic criteria of metabolic (dysfunction)-associated fatty liver disease (MAFLD) are unknown.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Nutrition & Dietetics
Zeinab Mokhtari, Elham Hosseini, Azita Hekmatdoost, Natasha Haskey, Deanna L. Gibson, Gholamreza Askari
Summary: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and there is currently no confirmed treatment. Fasting diets have recently gained attention as a potential adjunctive therapeutic strategy for NAFLD, with possible mechanisms including modulation of hepatic steatosis, fibroblast growth factors 19 and 21 signaling, lipophagy, and the metabolic profile.
Article
Medicine, General & Internal
Vanisha Patel, Parth Shah, Daniel R. Ludwig, Chet W. Hammill, Motaz Ashkar
Summary: This study aimed to determine the incidence and identify peri-operative risk factors for de novo non-alcoholic fatty liver disease (NAFLD) after pancreatectomy. The overall incidence of de novo NAFLD was 17.5%, with higher rates observed in patients with malignant indications for surgery compared to benign indications. The development of hepatic steatosis occurred earlier in the malignant group and was associated with higher pre-operative body mass index.
Article
Endocrinology & Metabolism
Ningning You, Jiali Xu, Liyan Wang, Lili Zhuo, Jingxin Zhou, Yu Song, Aliaweis Ali, Yan Luo, Jin Yang, Wenjun Yang, Minghua Zheng, Jing Xu, Li Shao, Junping Shi
Summary: The study found that there are significant differences in the gut fungal structure of NAFLD patients, and some fungi may be associated with NAFLD development, liver injury, and lipid metabolism. Therefore, research on gut fungi may have important value for diagnosing and monitoring NAFLD.
Review
Cell Biology
Amila Iriskic Atic, Maja Thiele, Alexander Munk, Louise Torp Dalgaard
Summary: MicroRNAs (miRNAs) secreted by the liver have the potential to be important biomarkers for nonalcoholic liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Several miRNAs, including miR-122, miR-21, miR-34a, miR-192, miR-193, and the miR-17-92 miRNA-cluster, are consistently associated with NAFLD/NASH. These miRNAs show potential as diagnostic markers for NAFLD/NASH, although more research is needed to understand their specificity and regulation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Food Science & Technology
Jing-Wen Yang, Hong-Fang Ji
Summary: Phytosterols are bioactive food components found in plant cell membranes, especially in nuts and oilseeds. Many studies have shown their therapeutic potential for nonalcoholic fatty liver disease (NAFLD). They lower total cholesterol and triglyceride levels through various mechanisms and improve NAFLD.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Julia A. Golubeva, Anna F. Sheptulina, Anastasia Yu. Elkina, Ekaterina O. Liusina, Anton R. Kiselev, Oxana M. Drapkina
Summary: Non-alcoholic fatty liver disease (NAFLD) and arterial hypertension (AH) are common non-communicable diseases worldwide. They often coexist and are associated with each other regardless of the presence of other metabolic factors.
Article
Geriatrics & Gerontology
Toshiki Maeda, Akira Babazono, Takumi Nishi, Midori Yasui
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2016)
Article
Multidisciplinary Sciences
Toshiki Maeda, Akira Babazono, Takumi Nishi, Midori Yasui, Shinya Matsuda, Kiyohide Fushimi, Kenji Fujimori
Article
Pharmacology & Pharmacy
Hiroki Miyazaki, Akira Babazono, Takumi Nishi, Toshiki Maeda, Takuya Imatoh, Masayoshi Ichiba, Hiroshi Une
BMC PHARMACOLOGY & TOXICOLOGY
(2015)
Article
Oncology
Toshiki Maeda, Akira Babazono, Takumi Nishi, Hiroki Miyazaki, Kazumitsu Tamaki, Masashi Fujii
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2016)
Article
Medicine, General & Internal
Toshiki Maeda, Akira Babazono, Takumi Nishi, Midori Yasui, Yumi Harano
Article
Medicine, General & Internal
Toshiki Maeda, Akira Babazono, Takumi Nishi, Midori Yasui, Yumi Harano
Article
Health Care Sciences & Services
Takumi Nishi, Toshiki Maeda, Akira Babazono
INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE
(2017)
Article
Health Care Sciences & Services
Takumi Nishi, Toshiki Maeda, Akira Babazono
POPULATION HEALTH MANAGEMENT
(2018)
Article
Public, Environmental & Occupational Health
Takuya Imatoh, Takumi Nishi, Midori Yasui, Toshiki Maeda, Kimie Sai, Yoshiro Saito, Hiroshi Une, Akira Babazono
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2018)
Article
Hematology
Toshiki Maeda, Akira Babazono, Takumi Nishi, Shinya Matsuda, Kiyohide Fushimi, Kenji Fujimori
BRITISH JOURNAL OF HAEMATOLOGY
(2015)
Article
Health Care Sciences & Services
Yan Gao, Akira Babazono, Takumi Nishi, Toshiki Maeda, Dulamsuren Lkhagva
POPULATION HEALTH MANAGEMENT
(2014)
Article
Endocrinology & Metabolism
Takumi Nishi, Akira Babazono, Toshiki Maeda, Takuya Imatoh, Hiroshi Une
JOURNAL OF DIABETES INVESTIGATION
(2015)
Article
Health Care Sciences & Services
Takumi Nishi, Toshiki Maeda, Takuya Imatoh, Akira Babazono
INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE
(2019)
Article
Endocrinology & Metabolism
Takumi Nishi, Akira Babazono, Toshiki Maeda
JOURNAL OF DIABETES INVESTIGATION
(2019)