Article
Chemistry, Multidisciplinary
Borja Cirera, Alexander Riss, Pingo Mutombo, Jose Urgel, Jose Santos, Marco Di Giovannantonio, Roland Widmer, Samuel Stolz, Qiang Sun, Max Bommert, Roman Fasel, Pavel Jelinek, Willi Auwarter, Nazario Martin, David Ecija
Summary: The design of organometallic complexes is crucial in modern organic chemistry and catalysis. On-surface synthesis has recently emerged as a disruptive method to design compounds and nanomaterials previously considered impossible. The activation of inner diacetylene moieties of a molecular precursor by copper surface adatoms has led to the formation of unprecedented organocopper metallacycles on Cu(111), paving the way for new avenues in organometallic compound engineering and polyyne chemistry on surfaces.
Correction
Chemistry, Inorganic & Nuclear
Firdaus Rahaman Gayen, Abdul Aziz Ali, Debashree Bora, Saptarshi Roy, Supriya Saha, Lakshi Saikia, Rajib Lochan Goswamee, Biswajit Saha
Summary: This study focuses on the synthesis and characterization of a ferrocene functionalized Schiff base containing Cu(II) complex, and demonstrates its catalytic activity in the azide alkyne cycloaddition reaction at parts-per-million levels.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Matt Timmers, Wouter Peeters, Niels J. Hauwert, Cristianne J. F. Rijcken, Tina Vermonden, Ingrid Dijkgraaf, Rob M. J. Liskamp
Summary: This article describes the site-specific attachment of the reactive TMTHSI-click handle to the N-terminus of peptides and proteins. The resulting molecular constructs can be used in strain-promoted azide alkyne cycloaddition (SPAAC) for reaction with azide-containing proteins. The article also discusses the N-terminal specific attachment of the reactive TMTHSI-click handle to peptides and proteins, followed by strain-promoted cycloaddition with azide-containing compounds.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Beatriz Lozano-Torres, Juan F. Blandez, Alba Garcia-Fernandez, Felix Sancenon, Ramon Martinez-Manez
Summary: This study describes a new method for senescent cell detection based on lipofuscin labeling using a biorthogonal reaction. The method involves a two-step reaction that forms a clear fluorescence pattern in senescent cells, providing an alternative tool for senescent cell detection.
Article
Chemistry, Organic
Robby Vroemans, Sergio R. Ribone, Joice Thomas, Luc Van Meervelt, Thierry Ollevier, Wim Dehaen
Summary: A new method for preparing novel homochiral atropisomeric sulfanyl- and sulfoxide-substituted naphthyltriazoles is described in this study, providing a new pathway for stable 1,2,3-triazole-based atropisomers. Sixteen sulfanyl-substituted naphthyltriazoles were obtained via triazolization reaction, followed by monooxidation. The absolute configuration of the substituted naphthyltriazoles was determined using X-ray crystallography and confirmed with computational DFT calculations.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Review
Chemistry, Physical
Chang-Qing Qin, Cheng Zhao, Guo-Shu Chen, Yun-Lin Liu
Summary: Catalytic enantioselective azide-alkyne cycloaddition (E-AAC) is an efficient technology for constructing diverse chiral triazoles, with applications in synthetic and medicinal chemistry, biological chemistry, and materials science. Significant developments have been made in copper-, nickel-, iridium-, and rhodium-catalyzed E-AAC reactions in the past six years. This review summarizes these advancements according to different strategies implemented.
Article
Chemistry, Organic
Carl T. Bormann, Christeena Mathew, Margarida M. Antonio, Aude Trotti, Farzaneh Fadaei-Tirani, Kay Severin
Summary: In this study, the synthesis of a terminal 1-alkynyl triazene is described, and subsequent functionalization expands the structural diversity of this compound class. Furthermore, its applications in the synthesis of di- and triynes, as well as in the preparation of (hetero)aromatic triazenes through metal-catalyzed cyclization reactions, are explored.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xiai Luo, Yu Zhao, Susu Tao, Zhong-Tao Yang, Hui Luo, Weiguang Yang
Summary: A simple synthesis method for (Z)-1,2-dihydro-2-iminoquinolines has been achieved using copper-catalyzed reaction of 1-(2-aminophenyl)ethan-1-ones, sulfonyl azides, and terminal ynones under mild conditions. The Z-configured products are obtained through a base-free CuAAC/ring-opening process due to hydrogen bonding.
Article
Chemistry, Multidisciplinary
Atul Kumar, Navaneet Kumar, Deepak Bhadoria
Summary: The first visible-light promoted and photocatalyst-free three-component reaction protocol has been developed to efficiently synthesize 4-functionalized 1,5-disubstituted 1,2,3-triazoles from terminal alkynes, aryl azides, and arylsulfinic acid sodium salts or arylsulfonyl hydrazides in an aqueous medium at room temperature. This reaction offers high regioselectivity, scalability, and good functional group tolerance among its advantages.
Review
Chemistry, Multidisciplinary
Yiming Liao, Baoqi Wu, Rongzhi Tang, Feng Lin, Yu Tan
Summary: This article reviews the wide application and advantages of SPAAC reaction in fields such as biomedicine and materials science. The stability and reactivity of cycloalkynes, as well as their reaction rate constants in SPAAC, are discussed. The research progress in the preparation methods of commonly used cyclic alkynes is introduced. Furthermore, the application, challenge, and future outlook of SPAAC without copper catalysis are discussed and prospected.
PROGRESS IN CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Jie Yan, Batjargal Gundsambuu, Marta Krasowska, Kirsten Platts, Paula Facal Marina, Cobus Gerber, Simon C. Barry, Anton Blencowe
Summary: In this study, an injectable hydrogel was developed using efficient Diels-Alder cycloaddition chemistry, allowing sustained release of T-cells with adjustable properties. This hydrogel shows a near-linear release profile, high cell viability, and controllable release period.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Fei-Fei Wang, Jia-Hui Li, Hai-Yan Liu, Shu-Ping Deng, Ying-Ying Liu, Jian-Fang Ma
Summary: Three distinctive coordination polymers were solvothermally synthesized using a resorcin[4]arene ligand. Among them, compound 1 showed efficient and selective catalytic performance, and could be recycled with preservation of its catalytic capability and structural integrity.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Suguru Yoshida, Yuki Sakata, Yoshihiro Misawa, Takamoto Morita, Tomoko Kuribara, Harumi Ito, Yuka Koike, Isao Kii, Takamitsu Hosoya
Summary: Efficient consecutive formation of 1,2,3-triazoles using multiazide platforms has been achieved in this study. A four-step synthesis of tetrakis(triazoles) was successfully performed from a tetraazide platform molecule, based on the unique clickability of the 1-adamantyl azido group. This method was applied to the convergent synthesis of tetrafunctionalized probes in a modular synthetic manner.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Samuel Pearce, Juan Perez-Mercader
Summary: By integrating various chemical processes, simplification of PISA process and routes to complexity and adaptation in chemical systems can be achieved.
ACS CENTRAL SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Gargi Chakraborti, Tirtha Mandal, Charles Patriot Roy, Jyotirmayee Dash
Summary: A cascade sequence involving [3+2] cycloaddition, 1,2-acyl migration and hydrolysis produces 2H-1,2,3-triazoles with regioselectivity, using a CuI-prolinamide catalyst system in aqueous media. Prolinamide promotes novel organocatalytic 1,2-acyl migration and hydrolysis of N-2-carboxyalkylated triazoles in the reaction.
CHEMICAL COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Shabnam Hemmati-Sadeghi, Pradip Dey, Jochen Ringe, Rainer Haag, Michael Sittinger, Tilo Dehne
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2019)
Article
Biochemistry & Molecular Biology
Shalini Kumari, Katharina Achazi, Pradip Dey, Rainer Haag, Jens Dernedd
Article
Chemistry, Multidisciplinary
Ranajit Barman, Pradip Dey, Tathagata Mondal, Suhrit Ghosh
CHEMISTRY-AN ASIAN JOURNAL
(2019)
Article
Multidisciplinary Sciences
Mohammad Suman Chowdhury, Wenshan Zheng, Shalini Kumari, John Heyman, Xingcai Zhang, Pradip Dey, David A. Weitz, Rainer Haag
NATURE COMMUNICATIONS
(2019)
Article
Polymer Science
Pradip Dey, Priya Rajdev, Prithankar Pramanik, Rainer Haag, Suhrit Ghosh
Review
Pharmacology & Pharmacy
Sabina Pozzi, Anna Scomparin, Sahar Israeli Dangoor, Daniel Rodriguez Ajamil, Paula Ofek, Lena Neufeld, Adva Krivitsky, Daniella Vaskovich-Koubi, Ron Kleiner, Pradip Dey, Shani Koshrovski-Michael, Noa Reisman, Ronit Satchi-Fainaro
Summary: Three-dimensional cancer models have been developed to study a wide range of biological applications, including cell signaling pathways, metastatic cascade steps, and personalized medicine, in vitro. By combining different cell types and external stimuli, these models can more accurately mimic the biology and pathophysiology of in vivo tumors.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Amrita Sikder, Saptarshi Chakraborty, Priya Rajdev, Pradip Dey, Suhrit Ghosh
Summary: Bioinspired self-assembly using amphiphiles with hydrophobic supramolecular-structure-directing-units has led to the creation of highly stable nanostructures, which are fundamentally different from traditional amphiphiles. The supramolecular assembly is primarily controlled by the specific molecular-recognition motif of the SSDU, enabling precise regulation of internal order and morphology. Additionally, SSDU-derived pi-amphiphiles have shown promise in producing temperature and redox-responsive supramolecular polymers with efficient functional group display and biological activity.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Mohammad Suman Chowdhury, Xingcai Zhang, Leila Amini, Pradip Dey, Abhishek Kumar Singh, Abbas Faghani, Michael Schmueck-Henneresse, Rainer Haag
Summary: This study introduces an oxidation-responsive precursor for creating multifunctional surfactants, which can stabilize microfluidics-generated aqueous droplets, encapsulate different components, enable extraction of biomolecules, fabrication of microcapsules, and monitoring of single-cell gene expression. The development of multifunctional surfactants presents opportunities for a wide range of applications in adsorption, bioanalytics, catalysis, formulations, coatings, and programmable emulsions.
NANO-MICRO LETTERS
(2021)
Article
Polymer Science
Priya Rajdev, Pradip Dey, Indranil Ghosh, Rajesh Khamrui, Joy Kar, Siddhartha Sankar Jana, Suhrit Ghosh
Summary: Cellular uptake of nanostructures is greatly influenced by the shape of the aggregate, with polymersomes showing the most efficient uptake compared to spherical or cylindrical micelles. The observed difference in cellular uptake can be attributed to the shape difference rather than intrinsic chemical structure. Further studies are needed to validate the impact of aggregate shape on cellular uptake in different cell lines.
Article
Materials Science, Multidisciplinary
Ranajit Barman, Priya Rajdev, Tathagata Mondal, Pradip Dey, Suhrit Ghosh
Summary: This article presents the synthesis of thermoresponsive alternating copolymers based on a segmented polyurethane scaffold. The polymers exhibit a lower critical solution temperature (LCST) and can form hollow capsules capable of sequestering hydrophilic guests. The LCST can be tuned by adjusting the degree of polymerization (DP) or hydrophobic/hydrophilic balance. The polymeric system shows excellent biocompatibility and has potential applications as a delivery vehicle in biomedical fields.
ACS APPLIED POLYMER MATERIALS
(2022)
Review
Nanoscience & Nanotechnology
Suhrit Ghosh, Ranajit Barman, Raju Bej, Pradip Dey
Summary: This paper presents the synthesis and self-assembly of a polymer-prodrug conjugate, as well as its stimuli-responsive intracellular dual drug delivery. The conjugate forms nanocapsule-like structures in water and releases the active drug in a reducing environment. The encapsulation of a second drug in the conjugate enhances its cell killing efficiency. These findings demonstrate the potential application of such a dual drug delivery approach.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Medicine, Research & Experimental
Yana Epshtein, Rachel Blau, Evgeni Pisarevsky, Shani Koshrovski-Michael, Dikla Ben-Shushan, Sabina Pozzi, Gal Shenbach-Koltin, Lidar Fridrich, Marina Buzhor, Adva Krivitsky, Pradip Dey, Ronit Satchi-Fainaro
Summary: This study designed novel polymeric imaging and therapeutic systems for comprehensive melanoma treatment management. By utilizing advanced imaging tools and therapeutic drugs, it can improve treatment efficacy and prevent tumor metastasis.
Article
Chemistry, Multidisciplinary
Goutam Ghosh, Pradip Dey, Suhrit Ghosh
CHEMICAL COMMUNICATIONS
(2020)
Review
Chemistry, Physical
Raju Bej, Pradip Dey, Suhrit Ghosh
Article
Materials Science, Biomaterials
Rotsiniaina Randriantsilefisoa, Jose Luis Cuellar-Camacho, Mohammad Suman Chowdhury, Pradip Dey, Uwe Schedler, Rainer Haag
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Article
Polymer Science
Paige A. Shaw, Maxime Klausen, Mark Bradley
Summary: A light-responsive polymer capable of controlled release of camptothecin and generation of reactive oxygen species (ROS) was developed, which exhibited high cancer cell killing activity through both camptothecin release and ROS generation.
Article
Polymer Science
Donghui Zhang, Shiqi Liu, Zhihao Cai, Weizhe Luo, Guojian Liu, Runhui Liu
Summary: A straightforward and efficient method for synthesizing NPC monomers has been developed in this study, which enhances the availability of NPC monomers and facilitates the synthesis of polypeptides.