Journal
POLYMER CHEMISTRY
Volume 7, Issue 39, Pages 6064-6074Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6py01130f
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Funding
- German Federal Ministry of Education & Research (BMBF) [031A518B]
- Thuringer Ministerium fur Wirtschaft, Wissenschaft, und Digitale Gesellschaft (Thuringian Ministry for Economic Affairs, Science and Digital Society, ProExzellenzII, NanoPolar)
- CarlZeiss Stiftung
- German Research Council (DFG) [LSM880]
- European Funds for Regional Developments (EFRE)
- DFG
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A series of amphiphilic heterografted comb polymers comprising various ratios of oligomeric polylactide (PLA) and poly(2-ethyl-2-oxazoline) (PEtOx) side chains was synthesized via the grafting-through method employing the reversible addition-fragmentation chain transfer copolymerization. Two well-defined PLA macromonomers were prepared via ring opening polymerization (ROP) of L-lactide using a calcium-based pre-catalyst, pyrenebutanol as an initiator and methacryloyl chloride as an end-capping agent. The PEtOx macromonomer was obtained from the cationic ROP of EtOx and end-capping with methacrylic acid. The amphiphilic comb polymers self-assembled in aqueous solution to form spherical and wormlike micelles, vesicles and more complex morphologies as a function of the composition, as is evident from dynamic light scattering and cryo-transmission electron microscopy studies. All polymers were found to be non-toxic to L929 cells up to a concentration of 200 mu g mL(-1). Cellular uptake studies with HEK-293 cells by live cell confocal fluorescence microscopy revealed localization in the cytosol after 4 h and suggest an energy-driven cellular uptake mechanism.
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