Article
Chemistry, Inorganic & Nuclear
Lukas Masaryk, Ivan Nemec, Jana Kasparkova, Viktor Brabec, Pavel Starha
Summary: In this study, model compounds such as Ru-dca and Ir-dca were used to investigate the behavior of complexes containing bioactive substituents like dichloroacetate (dca) in solution, with characterization done using techniques such as single-crystal X-ray analysis. However, these complexes did not demonstrate antiproliferative activity in four human cancer cell lines.
DALTON TRANSACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Rone Aparecido De Grandis, Analu Rocha Costa, Carlos Andre Ferreira Moraes, Natalia Zaneti Sampaio, Igor Henrique Cerqueira, Wellington Garcia Marques, Adriana Pereira Mundin Guedes, Joao Honorato de Araujo-Neto, Fernando Rogerio Pavan, Felipe Cerqueira Demidoff, Chaquip Daher Netto, Alzir Azevedo Batista, Flavia Aparecida Resende
Summary: In this study, two new Ru(II)/bipyridine/phenanthroline complexes containing lapachol as ligand were synthesized and tested for cytotoxicity against cancer cells. The results showed that one of the complexes exhibited selective toxicity against various cancer cells, which was related to the increase in reactive oxygen species and its potential binding to DNA. The findings contribute to the understanding of the anti-cancer potential and toxicological events of these new ruthenium complexes.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Priyaranjan Kumar, Prerana Singh, Sanjoy Saren, Juhi Sayala, Sri Sivakumar, Ashis K. Patra
Summary: This study designed six photoactive ruthenium quaternary complexes with multi-functional ligands for photoactivated chemotherapy. The structures and properties of these complexes were characterized using various experiments, and it was found that they exhibited good cytotoxicity and biocompatibility in cancer cells.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Physical
Carley Giffert L. Nongpiur, Akalesh Kumar Verma, Mayur Mohan Ghate, Krishna Mohan Poluri, Werner Kaminsky, Mohan Rao Kollipara
Summary: We designed and synthesized a series of new structurally related Ru(II), Rh(III), and Ir(III) chelating complexes. The complexes were characterized by physicochemical and spectroscopic methods. The antibacterial and cytotoxic activities of the synthesized ligands and metal complexes were evaluated. The results showed that the metal complexes exhibited good antibacterial activity and act as potent anticancer agents.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Carley Giffert L. Nongpiur, Akalesh Kumar Verma, Rohit Kumar Singh, Mayur Mohan Ghate, Krishna Mohan Poluri, Werner Kaminsky, Mohan Rao Kollipara
Summary: A series of new complexes of ruthenium(II), rhodium(III), and iridium(III) with pyrazoline-based ligands were synthesized and characterized. These compounds exhibited good antibacterial activity against Gram-positive bacteria and moderate antioxidant activity. They also showed moderate affinity for binding to Salmon Milt DNA and demonstrated higher cytotoxicity in Dalton's lymphoma cell lines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Tukki Sarkar, Arun Kumar, Somarupa Sahoo, Akhtar Hussain
Summary: The bioessential nature of cobalt and the rich photochemistry of its coordination complexes have been utilized to develop six novel mixed-ligand cobalt(III) complexes for studying their light-triggered cytotoxicity in cancer cells, with one of the complexes showing remarkable visible-light-triggered cytotoxicity against cancer cells.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Carley Giffert L. Nongpiur, Charlestine Soh, Danny F. Diengdoh, Akalesh Kumar Verma, Renu Gogoi, Venkanna Banothu, Werner Kaminsky, Mohan Rao Kollipara
Summary: A series of half-sandwich complexes containing 3-acetyl chromen-2one-4(N)-substituted thiosemicarbazone derivatives of ruthenium, iridium, and rhodium were synthesized and evaluated for their antibacterial and anticancer activities. The complexes were characterized using various spectral techniques and X-ray crystallography. The results showed that complex 5 exhibited the highest cytotoxicity in Dalton's lymphoma cells, followed by complex 4, 1, and 2.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Lihua Guo, Xueyan Hu, Yanjing Yang, Wenyu An, Jie Gao, Qin Liu, Zhe Liu
Summary: A series of structurally related zwitterionic piano-stool rhodium(III) and ruthenium(II) complexes were synthesized and characterized in this study. Rhodium(III) complexes showed potent cytotoxicity against human cancer cells, while ruthenium(II) complexes did not exhibit significant cytotoxicity. The introduction of fluorinated substituent and phenyl ring enhanced the cytotoxicity of rhodium(III) complexes.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Priscila Pereira Silva-Caldeira, Antonio Carlos Almendagna de Oliveira Junior, Elene Cristina Pereira-Maia
Summary: This paper presents the synthesis and characterization of two new polypyridyl-hydrazone Schiff bases and their Ru(II) complexes, and explores their potential anticancer activity and interaction with DNA. The results demonstrate the potential antitumor effects of these ligands and complexes.
Article
Chemistry, Inorganic & Nuclear
Urszula K. Komarnicka, Sandra Koziel, Agnieszka Skorska-Stania, Agnieszka Kyziol, Francesco Tisato
Summary: In this study, new complexes based on ruthenium(II) and iridium(III) with phosphine ligands and phenyl rings with/without methoxy motifs were synthesized and characterized. The complexes showed high catalytic efficiency in the oxidation of NADH to NAD(+) and exhibited potential applications in biological and medical fields. Furthermore, they demonstrated redox activity and significant cytotoxicity against various cancer cell lines.
DALTON TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Monica Martinez-Estevez, Soledad Garcia-Fontan, Saray Argibay-Otero, Inmaculada Prieto, Ezequiel M. Vazquez-Lopez
Summary: In this study, the reaction between [Ru2Cl2(mu-Cl)(2)(eta(6)-p-cymene)(2)] and two thiosemicarbazones was investigated. The resulting cationic complexes were isolated and characterized. The study revealed the presence of two isomers in the triflate salts and only one isomer in the chloride. X-ray crystallography confirmed this finding. The coordination of the thiosemicarbazone ligand to the ruthenium center was also demonstrated.
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Orsolya Domotor, Tamas Pivarcsik, Janos P. Meszaros, Istvan Szatmari, Ferenc Fulop, Eva A. Enyedy
Summary: The study highlighted the interaction between half-sandwich anticancer organometallic complexes and proteins, discussing their binding characteristics with human serum albumin and potential binding sites, providing important insights for the pharmacological and toxicological applications of these compounds.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Olga Mazuryk, Ewelina Janczy-Cempa, Justyna Lagosz, Dorota Rutkowska-Zbik, Agata Machnicka, Aneta Krasowska, Piotr Pietrzyk, Grazyna Stochel, Malgorzata Brindell
Summary: This study investigated the correlation between the spectroscopic and photophysical properties of Ru(ii) polypyridyl complexes and their photodynamic activity in vitro. The Ru(ii) complexes were found to exhibit phototoxic activity mainly through the generation of H2O2 and O-1(2), highlighting the importance of electron-transfer processes in their observed photodynamic activity. The compounds also retained their cytotoxic activity under hypoxic conditions, suggesting a potential for overcoming limitations in photodynamic therapy.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Medicinal
Alena Mrkvicova, Eva Peterova, Ivan Nemec, Radka Krikavova, Darina Muthna, Radim Havelek, Petra Kazimirova, Martina Rezacova, Pavel Starha
Summary: This study synthesized nine half-sandwich Rh(III) and Ru(II) complexes and investigated their antiproliferative activity in human cancer cell lines. The Rh(III) complex 6 showed high activity in ovarian cancer cells, including those resistant to the conventional drug cisplatin, with promising selectivity and a unique mechanism of action. It reduced DNA synthesis and upregulated CDKN1A expression, but did not induce p21 expression. The study concluded that complex 6 exhibited high antiproliferative activity through a p21-independent mechanism of action.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Vera A. Alferova, Tinashe P. Maviza, Mikhail Biryukov, Yuliya Zakalyukina, Dmitrii A. Lukianov, Dmitry A. Skvortsov, Lilia A. Vasilyeva, Vadim N. Tashlitsky, Vladimir Polshakov, Petr Sergiev, Vladimir A. Korshun, Ilya A. Osterman
Summary: The aromatic polyketide tetracenomycin X (TcmX) has been discovered as a potent protein synthesis inhibitor, showing potential for drug development against drug-resistant pathogens. This study reports the isolation and structure elucidation of a novel natural TcmX congener called 6-hydroxytetraceonomycin X (6-OH-TcmX), which exhibits lower antimicrobial activity but comparable protein synthesis inhibition ability. The differences in spectral properties between TcmX and 6-OH-TcmX make them suitable candidates for semi-synthetic drug development.
Article
Biochemistry & Molecular Biology
Philipp I. Pletnev, Olga Shulenina, Sergey Evfratov, Vsevolod Treshin, Maksim F. Subach, Marina V. Serebryakova, Ilya A. Osterman, Alena Paleskava, Alexey A. Bogdanov, Olga A. Dontsova, Andrey L. Konevega, Petr Sergiev
Summary: This study identified another key enzyme, RimI, responsible for acetylation modification in bacteria and demonstrated that acetylation of EF-Tu increases the efficiency of in vitro translation. Additionally, the absence of RimI in the strain resulted in reduced growth rate and potentially promoted conservation of the acetylation mechanism in the translation apparatus.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Vera A. Alferova, Tinashe P. Maviza, Mikhail V. Biryukov, Yuliya V. Zakalyukina, Vladimir I. Polshakov, Petr V. Sergiev, Vladimir A. Korshun, Ilya A. Osterman
Summary: Recently discovered aromatic polyketide tetracenomycins are potent inhibitors of protein synthesis, with a unique binding site located within the tunnel of the large ribosomal subunit. We report the isolation and structure elucidation of a novel tetracenomycin congener, O4-Me-tetracenomycin C, which is isomeric to tetracenomycin X. However, unlike tetracenomycin X, O4-Me-tetracenomycin C showed no antimicrobial activity and failed to inhibit protein synthesis in vitro. Structural alignment of tetracenomycins revealed the crucial role of the 4-hydroxyl group. These findings are important for the development of semi-synthetic tetracenomycins as potential antibacterials.
Article
Biochemistry & Molecular Biology
Olga A. Averina, Oleg A. Permyakov, Mariia A. Emelianova, Olga O. Grigoryeva, Mikhail Gulyaev, Olga S. Pavlova, Sofia S. Mariasina, Olga Yu Frolova, Marina Kurkina, Galina Baydakova, Ekaterina Yu Zakharova, Maria Marey, Dmitry A. Tsarev, Vadim N. Tashlitsky, Vladimir S. Popov, Maxim L. Lovat, Vladimir I. Polshakov, Mikhail Yu Vyssokikh, Petr Sergiev
Summary: Mitoregulin (Mtln) is a mitochondrial peptide that enhances the function of respiratory complex I by modulating lipid composition. Knockout mice deficient in Mtln gene showed obesity on a high fat diet, which was attributed to enhanced fat accumulation based on magnetic resonance imaging. In addition, these mice exhibited elevated serum triglycerides, exhaustion of tricarboxylic acids cycle intermediates, and suboptimal oxidation of respiration substrates by mitochondria lacking Mtln.
Article
Chemistry, Inorganic & Nuclear
Daniil Spector, Alexander Erofeev, Peter Gorelkin, Dmitry Skvortsov, Alexander Trigub, Alina Markova, Vita Nikitina, Nikolay Ul'yanovskiy, Alexander Shtil, Alevtina Semkina, Ksenia Vlasova, Nikolay Zyk, Alexander Majouga, Elena Beloglazkina, Olga Krasnovskaya
Summary: A design of Pt(iv) prodrugs with tumor cell targeting moieties leading to increased selectivity is of interest. Herein, we designed a novel Pt(iv) prodrugs with COX-inhibitor naproxen, long-chain hydrophobic stearic acid moiety and biotin as axial ligands. We have established that for Pt(iv) prodrugs with biotin and naproxen or stearate in axial position, the lipophilicity rather than biotin receptors expression is the main factor of cytotoxicity. We also monitored the reduction speed of Pt(iv) prodrug 3 with naproxen and biotin in axial positions in A549 cells using XANES and demonstrated that the prodrug gradually releases cisplatin within 20 hours of incubation.
DALTON TRANSACTIONS
(2023)
Article
Infectious Diseases
Julia A. Pavlova, Andrey G. Tereshchenkov, Pavel A. Nazarov, Dmitrii A. Lukianov, Dmitry A. Skvortsov, Vladimir I. Polshakov, Byasilya F. Vasilieva, Olga V. Efremenkova, Mikhail Y. Kaiumov, Alena Paleskava, Andrey L. Konevega, Olga A. Dontsova, Ilya A. Osterman, Alexey A. Bogdanov, Natalia V. Sumbatyan
Summary: To improve the properties of antimicrobial compounds, new conjugates were synthesized and studied, which consisted of two different biologically active agents in a single chimeric molecule based on chloramphenicol and a hydrophobic cation. These conjugates, named CAM-Cn-BER, effectively bound to the bacterial ribosome and inhibited protein synthesis, similar to chloramphenicol. CAM-C8-BER displayed selective inhibition of Gram-positive bacteria and acted on both the ribosome and the cell membrane. Moreover, CAM-Cn-BERs did not inhibit eukaryotic translation and were non-toxic to eukaryotic cells.
Correction
Microbiology
Yuliya V. Zakalyukina, Ilya A. Osterman, Jacqueline Wolf, Meina Neumann-Schaal, Imen Nouioui, Mikhail V. Biryukov
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Olga A. Averina, Oleg A. Permyakov, Mariia A. Emelianova, Olga O. Grigoryeva, Maxim L. Lovat, Anna E. Egorova, Andrei V. Grinchenko, Vadim V. Kumeiko, Maria V. Marey, Vasily N. Manskikh, Olga A. Dontsova, Mikhail Yu. Vysokikh, Petr V. Sergiev
Summary: Small peptides are important components of mitochondrial proteome, and the mitochondrial peptide Mtln plays a crucial role in respiratory complex I functioning and other processes in mitochondria. Knockout of Mtln in mice leads to obesity, triglyceride accumulation, and depletion of tricarboxylic acids cycle intermediates, indicating its important physiological functions. In addition, Mtln deficiency also impairs muscle strength, disrupts mitochondrial cardiolipin balance, and affects respiratory chain performance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Olga A. Averina, Oleg A. Permyakov, Mariia A. Emelianova, Ekaterina A. Guseva, Olga O. Grigoryeva, Maxim L. Lovat, Anna E. Egorova, Andrei V. Grinchenko, Vadim V. Kumeiko, Maria V. Marey, Vasily N. Manskikh, Olga A. Dontsova, Mikhail Y. Vyssokikh, Petr V. Sergiev
Summary: A small protein, Mitoregulin (Mtln), localized in mitochondria, plays a role in oxidative phosphorylation and fatty acid metabolism. Mtln knockout mice develop obesity and show damage to cardiolipin and creatine kinase oligomerization in muscle tissue. In this study, we investigate kidney-related phenotypes in aged Mtln knockout mice and found decreased respiratory complex I activity and excessive cardiolipin damage in kidney mitochondria similar to muscle mitochondria of Mtln knockout mice. Aged male mice with Mtln knockout exhibited increased renal proximal tubules' degeneration while aged female mice without Mtln showed a higher frequency of decreased glomerular filtration rate. Additionally, the amount of Mtln partner protein, Cyb5r3, decreased significantly in the kidneys of Mtln knockout mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Georgy L. Karetnikov, Dmitry A. Skvortsov, Anastasiia A. Moseicheva, Nikolay V. Zyk, Oksana B. Bondarenko
Summary: An efficient synthesis route for new hybrid isoxazole-triazole compounds was developed starting from 2-aryl-1,1-dichlorocyclopropanes or N-hydroxybenzimidoyl chlorides, achieving high yields and excellent regioselectivity. The synthesized compounds were evaluated for their biological activity.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Kseniya Shapovalova, Georgy Zatonsky, Natalia Grammatikova, Ilya Osterman, Elizaveta Razumova, Andrey Shchekotikhin, Anna Tevyashova
Summary: Aminoglycosides, one of the earliest antibiotics used clinically, still hold promise for the development of new antibacterial agents. We synthesized 6''-deoxykanamycin A analogues and found that introducing guanidine residues improved their activity against S. aureus. Furthermore, these modified kanamycin A derivatives showed reduced susceptibility to resistance mechanisms associated with mutations of elongation factor G.
Article
Microbiology
Shao-Wei Liu, Xiao-Xu Zhai, Di Liu, Yu-Yu Liu, Li-Ying Sui, Ke-Ke Luo, Qin Yang, Fei-Na Li, Arina A. Nikandrova, Arina N. Imamutdinova, Dmitrii A. Lukianov, Ilya A. Osterman, Petr V. Sergiev, Ben-Yin Zhang, De-Jun Zhang, Chun-Mei Xue, Cheng-Hang Sun
Summary: This study investigates the biodiversity and bioactive secondary metabolites of cultivable actinobacteria isolated from the sediments of saline lakes on the Northern Tibetan Plateau. Through the use of metabolomics and genomics approaches, potential bioactive compounds were rapidly identified, including potential novel anthracycline compounds.
Article
Food Science & Technology
Tamara S. Novik, Elena I. Koveshnikova, Anatoly A. Kotlobay, Lyudmila P. Sycheva, Karine G. Kurochkina, Olga A. Averina, Maria V. Belopolskaya, Petr V. Sergiev, Olga A. Dontsova, Vassili N. Lazarev, Igor V. Maev, Margarita G. Kostyaeva, Artem V. Eremeev, Svetlana I. Chukina, Maria A. Lagarkova
Summary: This article presents the results of a comprehensive toxicity assessment of yeast-produced recombinant sweet-tasting proteins, brazzein and monellin. The study confirms the safety and non-toxicity of these proteins for mammalian organisms, opening up vast opportunities for their application as sugar alternatives in the food industry.
Review
Biochemistry & Molecular Biology
J. A. Buyuklyan, Yu. V. Zakalyukina, I. A. Osterman, M. V. Biryukov
Summary: Representatives of the phylum Actinomycetota are important sources of secondary metabolites, including antibiotics. However, the production of these metabolites in laboratory conditions is low and there is a continuous rediscovery of known antibiotics, making new molecules harder to find. Established approaches to increase antibiotic production have limitations and are not always successful. Genetic engineering technologies, such as mutagenesis-based genome editing, offer a more efficient way to control and increase the production of target metabolites.
Article
Chemistry, Inorganic & Nuclear
Masoume Malmir, Majid M. Heravi, Zahra Yekke-Ghasemi, Masoud Mirzaei
Summary: In this study, a tri-component composite consisting of Fe3O4 nanoparticles, Keggin-type polyoxometalate, and graphene oxide was prepared and investigated as a catalyst for the oxidation of sulfides to sulfoxides. The catalyst showed excellent stability, high yields, and recyclability, making it a promising choice for organic-inorganic hybrid catalytic reactions conducted under mild conditions.
Article
Chemistry, Inorganic & Nuclear
Samuel D. Juarez-Escamilla, Sriloy Dey, Bruno Donnadieu, T. Keith Hollis
Summary: In this study, a bidentate Mo complex was synthesized using metalation and transmetalation methodology. The synthesis was optimized to achieve a high yield. The crystal structure of the bidentate complex was determined. Additionally, alternative forms of ligands were discovered in the reaction.
Article
Chemistry, Inorganic & Nuclear
Mohamed H. Abdel-Rhman, Ghada Samir, Mostafa A. Hussien, Nasser M. Hosny
Summary: This study investigated the dissolution performance of hydrazine carbonate solution on zirconium dibutyl phosphate (Zr-DBP), and found that hydrazine carbonate solution could promote the dissolution of Zr-DBP. The effects of dissolution temperature and hydrogen peroxide concentration on the dissolution efficiency were also explored, and the corrosion effect on stainless steel by hydrazine carbonate solution was studied.
Article
Chemistry, Inorganic & Nuclear
Qiaofang Fu, Fangyu Tan, Wu Ying
Summary: This study successfully prepared vermiculite/g-C3N4/TiO2 composites and found that under specific conditions, the composites exhibited excellent degradation effects, with a high degradation rate for methylene blue. Additionally, the composites were able to enhance surface area, reduce carrier loading rate, improve light energy utilization, and enhance durability.
Article
Chemistry, Inorganic & Nuclear
Annabelle G. W. Hodson, Robert T. Mason
Summary: Functionalised polystyrene resins have been found to be efficient catalysts in the synthesis of specific complexes, with the conversion rate controlled by the polymer structure. The addition of amines or amino acids can further yield substituted 13-butadienyl complexes, which have been analyzed by NMR.
Article
Chemistry, Inorganic & Nuclear
C. Kavitha, S. Anbarasan, P. Subramaniam
Summary: The sulfoxidation of PMAAs by the oxo(salen)chromium(V) complex in aqueous acetonitrile medium was studied. The rate of the reaction is influenced by the polarity of the medium and the substituents on PMAA, with electron donating substituents accelerating the reaction and electron withdrawing substituents retarding the reaction.
Article
Chemistry, Inorganic & Nuclear
Qiang-Qiang Liu, Mithun Kumar Ghosh, Shu-Lan Cai, Xiao-Hong Liu, Lu Lu, Mohd. Muddassir, Tanmay Kumar Ghorai, Jun Wang
Summary: Three newly developed coordination polymers (CPs) with semiconducting properties were synthesized using hydrothermal methods. These CPs exhibit superior photocatalytic activity and can degrade organic pollutants effectively.
Article
Chemistry, Inorganic & Nuclear
Mehrnaz Aliahmadi, Ali Nemati Kharat, Jan Janczak
Summary: This study proposes a method for synthesizing allyl alcohol using cost-effective and renewable bio-resource glycerol. By utilizing catalysts, alcohol as a solvent, and a reducing agent, allyl alcohol with an efficiency of 100% was obtained. The structures of the newly synthesized complexes were determined using X-ray single crystallography.
Article
Chemistry, Inorganic & Nuclear
Ji-Yan Gao, Nan Zhang, Dong-Sheng Huang, Xiang-Rong Liu, Zai-Wen Yang, Shun-Sheng Zhao
Summary: Two new transition metal complexes I and II were synthesized and characterized. The complexes exhibited strong thermal stabilities and showed effective binding to CT-DNA and BSA. Complex II exhibited stronger inhibition activity against P. aeruginosa than gentamicin sulfate. These complexes have potential applications in drug research.
Article
Chemistry, Inorganic & Nuclear
Rishabh Ujjval, Hilal Ahmad Khan, Chinnappan Sivasankar, Natesan Thirupathi
Summary: In this study, a rigid 2-aminobenzimidazole type guanidine and its platinum complexes were synthesized through a series of reactions and characterized by various physical and chemical methods. The reaction mechanism was also explained through DFT calculations.
Article
Chemistry, Inorganic & Nuclear
Marcelo Carpes Nunes, Thais Zaboenco, Vinicius Kemper Melara, Gabriel Barros Baptistella, Andre Luiz Barboza Formiga, Andersson Barison, Fabio Souza Nunes
Summary: A new luminescent molecular thermometer has been developed, which uses the spin-crossover equilibrium of a nickelcyclen derivative to measure temperature. The sensor shows high sensitivity and accuracy.
Article
Chemistry, Inorganic & Nuclear
Yuyu Shan, Zhenqin Zhao, Xia Zhang, Zhan Wu, Xiu-Ling Li
Summary: In this study, a new bridging ligand was synthesized through refluxing, and two mononuclear Cu(I) complexes and two trinuclear Cu(I)-Eu(III) complexes were obtained through self-assembly. The Cu(I) antenna chromophores successfully transferred energy to the Eu(III) centers, achieving sensitized Eu(III) luminescence.
Article
Chemistry, Inorganic & Nuclear
Gabriela Sanchez-Lecuona, Mayra C. Vazquez-Nunez, Bruno Donnadieu, Miguel A. Munoz-Hernandez, Virginia Montiel-Palma
Summary: The reaction of RuHCl(PPh3)3 with GaMe3 has been studied and the obtained complexes were analyzed in detail. The results indicate the formation of a Ru-Ga bond, suggesting the generation of an in situ formed ambiphilic phosphinogallyl ligand. This is of significance for understanding the interaction between metal-halogen bonds and metal-small molecule bonds.
Article
Chemistry, Inorganic & Nuclear
Sevil Sener, Nursel Acar, Fatih Dumludag
Summary: The synthesis, characterization, spectroscopic and bonding features of a new Co (II) phthalocyanine compound containing two thiocarbohydrazone groups were explained. The compound showed semiconductor properties and potential as a temperature sensor.
Article
Chemistry, Inorganic & Nuclear
Ledja B. O. Davi, Aryanna S. P. N. Costa, Mariana S. Silva, Adriana S. Ribeiro, Cintya D. A. E. S. Barbosa, Julio C. S. Da Silva, Dimas J. P. Lima, Daniela S. Anunciacao
Summary: In this study, a dansyl derivative sensor called o-PDDS was prepared and used for the detection of Al3+ ions in water. The o-PDDS sensor exhibited high sensitivity and linear response towards Al3+ ions. Experimental and computational studies confirmed a 1:1 stoichiometry ratio between o-PDDS and Al3+ ions. Real sample analysis demonstrated the selectivity and detection performance of the sensor, indicating its potential for field use.
