4.6 Article

Prioritization of Zoonotic Diseases in Kenya, 2015

Journal

PLOS ONE
Volume 11, Issue 8, Pages -

Publisher

PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0161576

Keywords

-

Funding

  1. US Centers for Disease Control and Prevention through Global Disease detection Division [GH000069]
  2. Wellcome Trust [110330/Z/15/Z]
  3. Wellcome Trust [110330/Z/15/Z] Funding Source: Wellcome Trust

Ask authors/readers for more resources

Introduction Zoonotic diseases have varying public health burden and socio-economic impact across time and geographical settings making their prioritization for prevention and control important at the national level. We conducted systematic prioritization of zoonotic diseases and developed a ranked list of these diseases that would guide allocation of resources to enhance their surveillance, prevention, and control. Methods A group of 36 medical, veterinary, and wildlife experts in zoonoses from government, research institutions and universities in Kenya prioritized 36 diseases using a semi-quantitative One Health Zoonotic Disease Prioritization tool developed by Centers for Disease Control and Prevention with slight adaptations. The tool comprises five steps: listing of zoonotic diseases to be prioritized, development of ranking criteria, weighting criteria by pairwise comparison through analytical hierarchical process, scoring each zoonotic disease based on the criteria, and aggregation of scores. Results In order of importance, the participants identified severity of illness in humans, epidemic/pandemic potential in humans, socio-economic burden, prevalence/incidence and availability of interventions (weighted scores assigned to each criteria were 0.23, 0.22, 0.21, 0.17 and 0.17 respectively), as the criteria to define the relative importance of the diseases. The top five priority diseases in descending order of ranking were anthrax, trypanosomiasis, rabies, brucellosis and Rift Valley fever. Conclusion Although less prominently mentioned, neglected zoonotic diseases ranked highly compared to those with epidemic potential suggesting these endemic diseases cause substantial public health burden. The list of priority zoonotic disease is crucial for the targeted allocation of resources and informing disease prevention and control programs for zoonoses in Kenya.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Immunology

Azithromycin and Ciprofloxacin Treatment Outcomes During an Outbreak of Multidrug-Resistant Shigella sonnei Infections in a Retirement Community-Vermont, 2018

Radhika Gharpure, Cindy R. Friedman, Veronica Fialkowski, Jennifer P. Collins, Jonathan Strysko, Zachary A. Marsh, Jessica C. Chen, Elizabeth H. Meservey, Azizat A. Adediran, Morgan N. Schroeder, Ashutosh Wadhwa, Kathleen E. Fullerton, Louise Francois Watkins

Summary: A study investigated a multi-drug resistant Shigella outbreak where 4 patients were treated with azithromycin, all of whom experienced treatment failure, with 2 also showing microbiologic failure; 2 patients who received ciprofloxacin treatment also failed. The findings underscore the importance of identifying alternative treatment options for resistant strains.

CLINICAL INFECTIOUS DISEASES (2022)

Article Geriatrics & Gerontology

Strategies associated with COVID-19 vaccine coverage among nursing home staff

Sarah D. Berry, Rosa R. Baier, Maggie Syme, Natalia Gouskova, Courtney Bishnoi, Urvi Patel, Michael Leitson, Radhika Gharpure, Nimalie D. Stone, Ruth Link-Gelles, David R. Gifford

Summary: The study found that strategies such as designated champions, setting targets, and non-monetary awards were associated with higher staff COVID-19 vaccination coverage in U.S. nursing homes.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2022)

Article Public, Environmental & Occupational Health

Surveillance of COVID-19 Vaccination in Nursing Homes, United States, December 2020-July 2021

Andrew Geller, Daniel S. Budnitz, Heather Dubendris, Radhika Gharpure, Minn Soe, Hsiu Wu, Elizabeth J. Kalayil, Andrea L. Benin, Suchita A. Patel, Megan C. Lindley, Ruth Link-Gelles

Summary: Monitoring COVID-19 vaccination coverage among nursing home residents and staff is crucial for patient safety policies. The study found a high correlation between vaccination data reported by pharmacies and nursing homes, and the coverage rates have been increasing over time.

PUBLIC HEALTH REPORTS (2022)

Article Multidisciplinary Sciences

Endemicity of Coxiella burnetii infection among people and their livestock in pastoral communities in northern Kenya

Josphat Muema, Mutono Nyamai, Nick Wheelhouse, Joseph Njuguna, Christine Jost, Julius Oyugi, Zipporah Bukania, Harriet Oboge, Brian Ogoti, Anita Makori, Maria del Pilar Fernandez, Sylvia Omulo, S. M. Thumbi

Summary: This study conducted in pastoralist communities in Marsabit County, northern Kenya, estimated the seroprevalence of Q-fever and associated risk factors of exposure in people and their livestock. The findings revealed that Q-fever is endemic in this setting.

HELIYON (2022)

Article Medicine, General & Internal

A global analysis of One Health Networks and the proliferation of One Health collaborations

Athman Mwatondo, Afifah Rahman-Shepherd, Lara Hollmann, Scott Chiossi, Josphat Maina, Karishma Krishna Kurup, Osama Ahmed Hassan, Beatrice Coates, Mishal Khan, Julia Spencer, Nyamai Mutono, Samuel M. Thumbi, Mathew Muturi, Mumbua Mutunga, Lia Barbara Arruda, Melika Akhbari, Dena Ettehad, Francine Ntoumi, Terence P. Scott, Louis H. Nel, Johanne Ellis-Iversen, Ute Wolff Sonksen, Diana Onyango, Zuleka Ismail, Kebadu Simachew, David Wolking, Rudovick Kazwala, Zikankuba Sijali, Bernard Bett, David Heymann, Richard Kock, Alimuddin Zumla, Osman Dar

Summary: The COVID-19 pandemic has led to a renewed focus on threats at the human-animal-environment interface, resulting in an expected increase in One Health collaborations. This study examines the global distribution of existing One Health Networks (OHNs) and identifies potential deficits in their formation and effectiveness. The findings highlight uneven distribution and prioritization of OHNs, with a need for greater diversity and inclusivity in stakeholder representation.

LANCET (2023)

Article Veterinary Sciences

Sero - epidemiology of brucellosis in people and their livestock: A linked human - animal cross-sectional study in a pastoralist community in Kenya

Josphat Muema, Harriet Oboge, Nyamai Mutono, Anita Makori, Julius Oyugi, Zipporah Bukania, Joseph Njuguna, Christine Jost, Brian Ogoti, Sylvia Omulo, S. M. Thumbi

Summary: This study investigated the seroprevalence and risk factors of brucellosis in pastoralist communities in Marsabit County, Kenya. The results showed that brucellosis is endemic in this area and there is a significant association between human and animal brucellosis at the household level. This highlights the importance of public health education and continuous screening for brucellosis in humans and animals.

FRONTIERS IN VETERINARY SCIENCE (2022)

Article Immunology

Seasonal influenza vaccination in the Americas: Progress and challenges during the COVID-19 pandemic

Francisco Nogareda, Radhika Gharpure, Marcela Contreras, Martha Velandia, Carmelita Lucia Pacis, Ana Elena Chevez, Eduardo Azziz-Baumgartner, Daniel Salas

Summary: This article describes the policies, coverage, and progress of seasonal influenza vaccination programs in the Americas from 2019 to 2021, as well as the challenges in monitoring and maintaining vaccination coverage during the COVID-19 pandemic. The results show that countries in the Americas successfully adapted their influenza vaccination delivery during the pandemic, but reported vaccination coverage decreased from 2019 to 2021.

VACCINE (2023)

Article Immunology

Effect of Phone Text Message Reminders on Compliance with Rabies Post-Exposure Prophylaxis following Dog Bites in Rural Kenya

Veronicah M. M. Chuchu, Nyamai Mutono, Philet Bichanga, Philip M. M. Kitala, Daniel Ksee, Mathew Muturi, Athman Mwatondo, Carolyne Nasimiyu, Lawrence Akunga, Amine Amiche, Katie Hampson, Samuel M. M. Thumbi

Summary: Sending SMS reminders to bite patients in rural eastern Kenya can improve their adherence to scheduled rabies prophylaxis, reduce treatment delay, alleviate financial burden, and contribute to rabies control and elimination strategies.

VACCINES (2023)

Article Public, Environmental & Occupational Health

United Against Rabies Forum: The first 2 years

Rachel Tidman, Anna Sophie Fahrion, S. M. Thumbi, Ryan M. Wallace, Katinka De Balogh, Vivian Iwar, Gowri Yale, Isabelle Dieuzy-Labaye

Summary: Rabies still claims the lives of approximately 59,000 people annually, mostly due to dog bites. The Zero by 30 initiative, aiming to end human deaths from dog-mediated rabies by 2030, provides a framework for achieving this through a One Health approach. In 2020, the United Against Rabies Forum was established to further this global goal. This paper reviews the objectives, governance, activities, and achievements of the Forum, and discusses future plans and priority areas.

FRONTIERS IN PUBLIC HEALTH (2023)

Article Engineering, Chemical

Modelling seasonal household variation in harvested rainwater availability: a case study in Siaya County, Kenya

Weiyu Yu, Peggy Wanza, Emmah Kwoba, Thumbi Mwangi, Joseph Okotto-Okotto, Diogo Trajano Gomes da Silva, Jim A. Wright

Summary: This study investigated the reliability of rainwater harvesting using a modelling approach that integrated household surveys with gridded precipitation data. The results showed that the majority of households (95.1%) that consumed rainwater faced insufficient supply throughout the year, with even more intermittent supply during the short rains for households with alternative improved sources.

NPJ CLEAN WATER (2023)

Review Nutrition & Dietetics

The impact of livestock interventions on nutritional outcomes of children younger than 5 years old and women in Africa: a systematic review and meta-analysis

Josphat Muema, Nyamai Mutono, Stevens Kisaka, Brian Ogoti, Julius Oyugi, Zipporah Bukania, Tewoldeberhan Daniel, Joseph Njuguna, Irene Kimani, Anita Makori, Sylvia Omulo, Erin Boyd, Abdal Monium Osman, Luc Gwenaelle, Christine Jost, S. M. Thumbi

Summary: Nutrition-sensitive livestock interventions have the potential to improve nutrition and household income in communities dependent on livestock in Africa. However, there is a lack of synthesized empirical evidence on the impact and effect of these interventions on diets and nutritional status.

FRONTIERS IN NUTRITION (2023)

Letter Medicine, General & Internal

Conflicting COVID-19 excess mortality estimates

Matshidiso Moeti, Lindiwe Makubalo, Abdou Salam Gueye, Thierno Balde, Humphrey Karamagi, Gordon Awandare, S. M. Thumbi, Feifei Zhang, Francisca Mutapi, Mark Woolhouse

LANCET (2023)

Article Public, Environmental & Occupational Health

The COVID-19 pandemic and disruptions to essential health services in Kenya: a retrospective time-series analysis

Helen Kiarie, Marleen Temmerman, Mutono Nyamai, Nzisa Liku, Wangari Thuo, Violet Oramisi, Lilly Nyaga, Janette Karimi, Phidelis Wamalwa, Gladwell Gatheca, Valerian Mwenda, Loice Achieng Ombajo, S. M. Thumbi

Summary: The study assessed the impact of the COVID-19 pandemic on essential health-care services in Kenya and found significant decreases in several indicators. The health-care workers' strike further exacerbated the disruption of essential health services.

LANCET GLOBAL HEALTH (2022)

Article Immunology

Multistate Outbreak of SARS-CoV-2 Infections, Including Vaccine Breakthrough Infections, Associated with Large Public Gatherings, United States

Radhika Gharpure, Samira Sami, Johanna Vostok, Hillary Johnson, Noemi Hall, Anne Foreman, Rebecca T. Sabo, Petra L. Schubert, Hanna Shephard, Vance R. Brown, Ben Brumfield, Jessica N. Ricaldi, Andrew B. Conley, Lindsay Zielinski, Lenka Malec, Alexandra P. Newman, Michelle Chang, Lauren E. Finn, Cameron Stainken, Anil T. Mangla, Patrick Eteme, Morgan Wieck, Alison Green, Alexandra Edmundson, Diana Reichbind, Vernell Brown, Laura Quinones, Allison Longenberger, Elke Hess, Megan Gumke, Alicia Manion, Hannah Thomas, Carla A. Barrios, Adrianna Koczwara, Thelonious W. Williams, Marcia Pearlowitz, Moussokoura Assoumou, Alessandra F. Senisse Pajares, Hope Dishman, Cody Schardin, Xiong Wang, Kendalyn Stephens, Nakema S. Moss, Gurpalik Singh, Christine Feaster, Lindsey Martin Webb, Anna Krueger, Kristen Dickerson, Courtney Dewart, Bree Barbeau, Amelia Salmanson, Lawrence C. Madoff, Julie M. Villanueva, Catherine M. Brown, A. Scott Laney

Summary: During July 2021, a multistate investigation was conducted after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.617.2 variant infections, including vaccine breakthrough infections, occurred following large public gatherings in Provincetown, Massachusetts, USA. The investigation revealed that large gatherings can have widespread effects on SARS-CoV-2 transmission, and even fully vaccinated individuals should take precautions to prevent transmission.

EMERGING INFECTIOUS DISEASES (2022)

No Data Available