Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity

Signal transducer and activator of transcription 3 and 5 regulate system Xc- and redox balance in human breast cancer cells

(2015) Katja Linher-Melville et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Inhibitors of glutamate release from breast cancer cells; new targets for cancer-induced bone-pain

(2015) Jennifer Fazzari et al.   Scientific Reports

The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells

(2014) Katja Linher-Melville et al.   BMC CANCER

Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation

(2014) M Girardot et al.   ONCOGENE

Identification of STAT5A and STAT5B Target Genes in Human T Cells

(2014) Takahiro Kanai et al.   PLoS One

Toward a new STATe: The role of STATs in mitochondrial function

(2014) Jeremy A. Meier et al.   SEMINARS IN IMMUNOLOGY

The ROS/SUMO Axis Contributes to the Response of Acute Myeloid Leukemia Cells to Chemotherapeutic Drugs

(2014) Guillaume Bossis et al.   Cell Reports

STAT3 Target Genes Relevant to Human Cancers

(2014) Richard Carpenter et al.   Cancers

Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention

(2014) Ailian Xiong et al.   Cancers

Comparison of software packages for detecting differential expression in RNA-seq studies

(2013) F. Seyednasrollah et al.   BRIEFINGS IN BIOINFORMATICS

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

The SUMO system: a master organizer of nuclear protein assemblies

(2013) Nithya Raman et al.   CHROMOSOMA

Cellular metabolic and autophagic pathways: Traffic control by redox signaling

(2013) Matthew Dodson et al.   FREE RADICAL BIOLOGY AND MEDICINE

The small molecule, genistein, increases hepcidin expression in human hepatocytes

(2013) Aileen W. Zhen et al.   HEPATOLOGY

SUMO: a (Oxidative) Stressed Protein

(2013) Marco Feligioni et al.   NEUROMOLECULAR MEDICINE

NRF2-ome: An Integrated Web Resource to Discover Protein Interaction and Regulatory Networks of NRF2

(2013) Dénes Türei et al.   Oxidative Medicine and Cellular Longevity

Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain

(2013) Robert G. Ungard et al.   PAIN

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma

(2013) Sina Haftchenary et al.   ACS Medicinal Chemistry Letters

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

The pharmacologic inhibition of the xc- antioxidant system improves the antitumor efficacy of COX inhibitors in the in vivo model of 3-MCA tumorigenesis

(2012) E. Balza et al.   CARCINOGENESIS

Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS–JNK–CHOP-mediated upregulation of death receptors

(2012) Bokyung Sung et al.   FREE RADICAL BIOLOGY AND MEDICINE

Breast Cancer Anti-estrogen Resistance 3 (BCAR3) Protein Augments Binding of the c-Src SH3 Domain to Crk-associated Substrate (p130cas)

(2012) Anthony Makkinje et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMO-Specific Protease 1 Is Critical for Early Lymphoid Development through Regulation of STAT5 Activation

(2012) Thang Van Nguyen et al.   MOLECULAR CELL

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

(2011) Takatsugu Ishimoto et al.   CANCER CELL

Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells

(2011) DunFa Peng et al.   GUT

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis

(2011) J. D. Kessler et al.   SCIENCE

ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments

(2010) Alexander Lachmann et al.   BIOINFORMATICS

DMBT1 is a novel gene induced by IL-22 in ulcerative colitis

(2010) Hirokazu Fukui et al.   INFLAMMATORY BOWEL DISEASES

Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences

(2010) Jeremy Goecks et al.   GENOME BIOLOGY

SUMO Proteases: Redox Regulation and Biological Consequences

(2009) Zheng Xu et al.   ANTIOXIDANTS & REDOX SIGNALING

The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome

(2009) J. J. Driscoll et al.   BLOOD

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Reciprocal Effects of STAT5 and STAT3 in Breast Cancer

(2009) S. R. Walker et al.   MOLECULAR CANCER RESEARCH

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Discovery of Chromone-Based Inhibitors of the Transcription Factor STAT5

(2008) Judith Müller et al.   CHEMBIOCHEM

The xc− cystine/glutamate antiporter: A potential target for therapy of cancer and other diseases

(2008) Maisie Lo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

In vivo identification of novel STAT5 target genes

(2008) B. Basham et al.   NUCLEIC ACIDS RESEARCH

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/β-catenin pathway

(2008) R-S Chen et al.   ONCOGENE