Article
Pathology
Pallavi Srivastava, Sridhar Mishra, Akash Agarwal, Anshuman Pandey, Nuzhat Husain
Summary: Circulating microRNAs (miRNAs) could be used as biomarkers for cancer detection. This study aimed to identify specific miRNA expression in serum as a biomarker for early detection of gallbladder carcinoma (GBC) and evaluate their diagnostic potential. The results showed differential expression of miRNAs in GBC and their potential as non-invasive diagnostic biomarkers.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biotechnology & Applied Microbiology
Zohreh Heydari, Emadoddin Moudi, Farzin Sadeghi, Mahmoud Hajiahmadi, Setareh Rezatabar, Nahid Neamati, Hadi Parsian
Summary: This study investigated the expression level of miR222-3p in plasma samples of prostate cancer patients. The results showed that miR222-3p was significantly upregulated in prostate cancer patients, suggesting its potential as a biomarker for distinguishing prostate cancer from healthy individuals.
JOURNAL OF GENE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Anelis Maria Marin, Sibelle Botogosque Mattar, Rafaela Ferreira Amatuzzi, Roger Chammas, Miyuki Uno, Dalila Luciola Zanette, Mateus Nobrega Aoki
Summary: Pancreatic cancer is a leading cause of cancer-related death worldwide, and early diagnosis is crucial. Plasma microRNAs have emerged as potential non-invasive biomarkers for diagnosis and prognosis. This study identified specific microRNAs that were overexpressed in the plasma exosomes of pancreatic cancer patients, suggesting their potential as diagnostic and prognostic markers.
Review
Biochemistry & Molecular Biology
Ombretta Repetto, Roberto Vettori, Agostino Steffan, Renato Cannizzaro, Valli De Re
Summary: Gastric cancer is a highly malignant disease with poor prognosis. Early detection and personalized treatment are important for improving patient survival. Recent advances in proteomics technologies have enabled the identification of novel biomarkers for gastric cancer, supporting the development of precision medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Xin-qiang Liang, Ke-zhi Li, Zhao Li, Ming-zhi Xie, Yan-pin Tang, Jiang-biao Du, Yi Huang, Ji-lin Li, Bang-li Hu
Summary: The study revealed that plasma Hsp90 alpha levels were significantly elevated in gastric cancer patients, correlated with tumor biomarkers and immune cells, but had no predictive value for patient survival.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Yinxing Zhu, Yixuan Hu, Xuedan Zhu, Juan Zhang, Daolu Yuwen, Xiaowei Wei, Cuiju Tang, Wenwen Zhang
Summary: The study evaluates the diagnostic value of thioredoxin reductase 1 (TXNRD1) and finds that its overexpression is associated with poor prognosis in gastric cancer patients. Plasma thioredoxin reductase levels are significantly higher in gastric cancer patients compared to benign disease and healthy controls. The combined detection of thioredoxin reductase and routine tumor markers improves diagnostic efficacy and plasma thioredoxin reductase has the potential to monitor therapeutic efficacy.
Review
Oncology
Jian Li, Yanyan Zhang, Qingyu Xu, Yaqiong Zhang, Songhua Bei, Ying Ding, Xiaohong Zhang, Li Feng
Summary: This meta-analysis revealed that serum or plasma lncRNAs have high sensitivity and specificity, making them clinically feasible in diagnosing gastric cancer (GC). The results suggest that peripheral blood lncRNAs may become novel noninvasive biomarkers in the foreseeable future. However, further studies are needed to validate their applicability as cancer biomarkers.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Jelena Jankovic Miljus, Maria Augusta Guillen-Sacoto, Jennifer Makiadi-Alvarado, Leon Wert-Lamas, Julia Ramirez-Moya, Mercedes Robledo, Pilar Santisteban, Garcilaso Riesco-Eizaguirre
Summary: This study identified two putative novel miRNAs that rise with rhTSH stimulation in the serums of patients with recurrent/persistent thyroid cancer. However, known miRNAs were not found to be circulating markers for thyroid cancer recurrence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Zhilong Yu, ZeYin Rong, Jinxin Sheng, Zai Luo, Jianming Zhang, Tengfei Li, Zhonglin Zhu, Zhongmao Fu, Zhengjun Qiu, Chen Huang
Summary: Recent studies have shown that non-coding RNAs (ncRNAs) may serve as novel biomarkers for predicting the occurrence and prognosis of gastric cancer. By analyzing the expression profiles of miRNA, lncRNA, and cirRNA in gastric cancer patients, it was found that these ncRNAs could potentially be promising molecular markers for the diagnosis and prognosis of gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jen-Tai Lin, Kuo-Wang Tsai
Summary: The study showed that certain miRNAs in urine could potentially serve as noninvasive biomarkers for diagnosing bladder cancer, with implications for early detection and patient survival. Further validation in larger cohorts is necessary to confirm the clinical utility of urinary miRNAs in bladder cancer diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Dai Koguchi, Kazumasa Matsumoto, Izuru Shiba, Takahiro Harano, Satoshi Okuda, Kohei Mori, Shuhei Hirano, Kazuki Kitajima, Masaomi Ikeda, Masatsugu Iwamura
Summary: Early detection of bladder cancer is crucial, but current screening methods have limited diagnostic accuracy. Liquid biopsy, including CTCs, ucfDNA, and umiRNA, has shown promise as a complementary diagnostic tool. However, more research is needed to validate its clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Eric Gustavo Ramirez-Salazar, Luis Vicente Gayosso-Gomez, Renata Baez-Saldana, Ramces Falfan-Valencia, Rogelio Perez-Padilla, Anjarath L. Higuera-Iglesias, Maria E. Vazquez-Manriquez, Blanca Ortiz-Quintero
Summary: The study suggests that cigarette smoking can impact the reliable identification of circulating miRNAs as diagnostic biomarkers in lung cancer, with a potential pathogenic role of miR-133a-3p in smokers.
Article
Oncology
A. Adam-Artigues, I Garrido-Cano, S. Simon, B. Ortega, S. Moragon, A. Lameirinhas, V Constancio, S. Salta, O. Burgues, B. Bermejo, R. Henrique, A. Lluch, C. Jeronimo, P. Eroles, J. M. Cejalvo
Summary: miR-30b-5p expression in breast cancer tissue and plasma differs significantly from healthy samples, with higher levels in plasma of BC patients. This miRNA demonstrates good potential for early diagnosis of breast cancer.
Article
Cell Biology
Sara Bonlokke, Magnus Stougaard, Boe Sandahl Sorensen, Berit Bargum Booth, Estrid Hogdall, Gitte-Bettina Nyvang, Jacob Christian Lindegaard, Jan Blaakaer, Jesper Bertelsen, Katrine Fuglsang, Mikael Lenz Strube, Suzan Lenz, Torben Steiniche
Summary: Circulating cell-free HPV DNA (ccfHPV DNA) can serve as a marker for cervical cancer. This study used digital droplet PCR (ddPCR) to detect and quantify ccfHPV DNA in plasma from patients with HPV16- or HPV18-associated cervical cancer. The results showed that ccfHPV DNA may not be useful for early detection of cervical cancer, but it can be a promising tool for establishing tumor burden and monitoring the disease in advanced stage cervical cancer patients.
Article
Biochemistry & Molecular Biology
Xianming Jiang, Xiaoguang Pan, Wenchao Li, Peng Han, Jiaying Yu, Jing Li, Haoran Zhang, Wei Lv, Ying Zhang, Yulong He, Xi Xiang
Summary: This study found that the abundance of eccDNA was significantly higher in gastric cancer tissues compared to normal tissues. The eccDNA carrying oncogene-segments may contribute to the development of gastric cancer and facilitate cancer progression. Blocking the pathways for eccDNA generation could be a potential therapeutic strategy for gastric cancer.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)