Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation

Quantitative High-Throughput Identification of Drugs as Modulators of Human Constitutive Androstane Receptor

(2015) Caitlin Lynch et al.   Scientific Reports

Advantages of cell-based high-volume screening assays to assess nuclear receptor activation during drug discovery

(2014) Marija Pinne et al.   Expert Opinion on Drug Discovery

Pregnane X Receptor Agonists Impair Postprandial Glucose Tolerance

(2013) J Rysä et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond

(2013) Xiaojuan Chai et al.   Expert Opinion on Drug Metabolism & Toxicology

Activation of Human Stearoyl-Coenzyme A Desaturase 1 Contributes to the Lipogenic Effect of PXR in HepG2 Cells

(2013) Jun Zhang et al.   PLoS One

Phenobarbital Indirectly Activates the Constitutive Active Androstane Receptor (CAR) by Inhibition of Epidermal Growth Factor Receptor Signaling

(2013) S. Mutoh et al.   Science Signaling

Targeting xenobiotic receptors PXR and CAR for metabolic diseases

(2012) Jie Gao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Multi-species Analyses of Direct Activators of the Constitutive Androstane Receptor

(2011) Curtis J. Omiecinski et al.   TOXICOLOGICAL SCIENCES

Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells

(2010) Philip Martin et al.   ACTA PHARMACOLOGICA SINICA

Identification of Clinically Used Drugs That Activate Pregnane X Receptors

(2010) S. J. Shukla et al.   DRUG METABOLISM AND DISPOSITION

5-Aminoimidazole-4-carboxamide-1-β-ribofuranoside (AICAR) prevents nuclear translocation of constitutive androstane receptor by AMP-activated protein kinase (AMPK) independent manner

(2010) Yuichiro Kanno et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): A novel signalling pathway sensitive to phthalates

(2009) Alexandre Eveillard et al.   BIOCHEMICAL PHARMACOLOGY

Nuclear Translocation of Adenoviral-Enhanced Yellow Fluorescent Protein-Tagged-Human Constitutive Androstane Receptor (hCAR): A Novel Tool for Screening hCAR Activators in Human Primary Hepatocytes

(2009) H. Li et al.   DRUG METABOLISM AND DISPOSITION

Dephosphorylation of Threonine 38 Is Required for Nuclear Translocation and Activation of Human Xenobiotic Receptor CAR (NR1I3)

(2009) Shingo Mutoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Single Amino Acid Controls the Functional Switch of Human Constitutive Androstane Receptor (CAR) 1 to the Xenobiotic-Sensitive Splicing Variant CAR3

(2009) T. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS