Article
Biotechnology & Applied Microbiology
Emma Sole, Rayner Gonzalez-Prendes, Yelyzaveta Oliinychenko, Marc Tor, Roger Ros-Freixedes, Joan Estany, Ramona N. Pena
Summary: Restricting dietary vitamin A during the fattening period did not improve intramuscular fat content, but there was an interaction between vitamin A and SCD genotype on the desaturation of fatty acids in muscle.
Article
Genetics & Heredity
Hao Li, Cineng Xu, Fanming Meng, Zekai Yao, Zhenfei Fan, Yingshan Yang, Xianglun Meng, Yuexin Zhan, Ying Sun, Fucai Ma, Jifei Yang, Ming Yang, Jie Yang, Zhenfang Wu, Gengyuan Cai, Enqin Zheng
Summary: This study analyzed the scoring results of flesh color and intramuscular fat in different time periods, revealing their genetic structure and identifying related genes and genetic loci, which is of great importance for improving pig meat quality traits.
Article
Agriculture, Dairy & Animal Science
Z. Zhuang, R. Ding, Y. Qiu, J. Wu, S. Zhou, J. Quan, E. Zheng, Z. Li, Z. Wu, J. Yang
Summary: This study identified a consistent QTL, additional genomic regions, and genes contributing to the genetic variance of IMF using a large sample size of genotyped pigs and genealogical information.
Article
Agriculture, Dairy & Animal Science
Z. Zhang, Z. Zhang, F. O. Oyelami, H. Sun, Z. Xu, P. Ma, Q. Wang, Y. Pan
Summary: The study conducted a single-step GWAS on 950 Duroc pigs and identified genomic loci that may affect intramuscular fat (IMF) without changing backfat thickness (BF). Specific genetic variants were found to potentially improve IMF without altering BF, indicating valuable targets for molecular breeding of IMF in Duroc pigs.
Article
Agriculture, Multidisciplinary
Bojiang Li, Yu He, Wangjun Wu, Xiaofan Tan, Zichenhan Wang, David M. Irwin, Zhe Wang, Shuyi Zhang
Summary: This study investigated the circRNA expression profile in the longissimus dorsi muscle of pigs with high and low IMF content. The results identified differentially expressed circRNAs related to lipid metabolism and adipogenesis processes. Among them, circPPARA was found to be positively correlated with IMF content and promoted intramuscular adipogenesis by adsorbing specific miRNAs. These findings provide valuable insights into the regulatory functions of circRNAs in porcine IMF and offer a resource for future circRNA research in pigs.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Dairy & Animal Science
Isaac Hyeladi Malgwi, Veronika Halas, Petra Grunvald, Stefano Schiavon, Ildiko Jocsak
Summary: Intramuscular fat (IMF) is an important indicator of pork sensory quality, influenced by dietary nutrients, genes, and metabolic pathways in pigs. Nutrigenetics and nutrigenomics provide a powerful tool for estimating nutrient requirements and programming dietary nutrient supply based on individual pig's genetic make-up. Understanding the mechanisms of fat metabolism and IMF deposition is crucial for improving swine production and economically important traits.
Article
Biotechnology & Applied Microbiology
Yingke Liu, Yilin Wei, Yaqing Dou, Chenlei Li, Chenglei Song, Zhe Zhang, Kunlong Qi, Xinjian Li, Ruimin Qiao, Kejun Wang, Xiuling Li, Feng Yang, Xuelei Han
Summary: Meat quality is an important trait in pig production, and the content of intramuscular fat (IMF) plays a significant role in determining pork quality. This study showed that overexpression of miR-149-5p in porcine IM preadipocytes altered lipid formation and inhibited adipogenic differentiation through the cAMP signaling pathway and targeting ATP7A, suggesting its potential as a key target for controlling pork quality.
Article
Chemistry, Applied
Xinhua Hou, Run Zhang, Man Yang, Naiqi Niu, Junchao Wu, Ze Shu, Pengfei Zhang, Lijun Shi, Fuping Zhao, Ligang Wang, Lixian Wang, Longchao Zhang
Summary: Chinese indigenous pig breeds have higher intramuscular fat content and better meat quality. This study investigated the differential metabolites and lipids in the skeletal muscle of Laiwu and Yorkshire pigs, revealing their association with intramuscular fat content and meat flavor. The results showed that the Laiwu pig had a faster lipid droplet formation and contained more triglyceride, reflecting its higher intramuscular fat content.
Article
Genetics & Heredity
Yanhui Zhao, Shaokang Chen, Jiani Yuan, Yumei Shi, Yan Wang, Yufei Xi, Xiaolong Qi, Yong Guo, Xihui Sheng, Jianfeng Liu, Lei Zhou, Chuduan Wang, Kai Xing
Summary: By analyzing the longissimus dorsi muscle of Songliao Black and Landrace pigs, we identified key genes and regulatory factors affecting intramuscular fat deposition, providing a reference for further understanding the regulatory mechanism of IMF.
Article
Endocrinology & Metabolism
Hui Feng, Tianyi Liu, Salsabeel Yousuf, Xiuxiu Zhang, Wanlong Huang, Ai Li, Lingli Xie, Xiangyang Miao
Summary: Through deep RNA sequencing, we identified differentially expressed lncRNAs, miRNAs, and mRNAs in subcutaneous and intramuscular adipose tissues in pigs with high meat quality. Bioinformatics analysis revealed key lncRNAs, miRNAs, and mRNAs involved in lipid metabolism and adipogenesis. We found that the Wnt signaling pathway plays a critical regulatory role in intramuscular adipogenesis and lipid accumulation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Chen Wei, Haonan Zeng, Zhanming Zhong, Xiaodian Cai, Jingyan Teng, Yuqiang Liu, Yunxiang Zhao, Xibo Wu, Jiaqi Li, Zhe Zhang
Summary: This study identified potential candidate genes affecting growth and carcass traits in pigs using whole-genome and transcriptome sequencing technologies. By analyzing the sequencing data of 4154 Duroc pigs, 80 significant genetic factors related to growth and carcass traits were discovered. These findings contribute to improving meat production and quality selection in pigs.
Article
Biochemistry & Molecular Biology
Yueyun Ding, Yinhui Hou, Zijing Ling, Qiong Chen, Tao Xu, Lifei Liu, Na Yu, Wenliang Ni, Xiaoling Ding, Xiaodong Zhang, Xianrui Zheng, Wenbin Bao, Zongjun Yin
Summary: This study assessed the whole transcriptome expression profiles of pigs' Longissimus dorsi muscle with high and low IMF content to identify genes involved in porcine IMF adipogenesis. The findings revealed the involvement of non-coding RNAs in fatty acid metabolic processes, lipid metabolism, and fat cell differentiation. The study also constructed competing endogenous RNAs (ceRNA) regulatory networks, highlighting the roles of lncRNAs, circRNAs, and miRNAs in IMF deposition. These findings provide potential regulators and molecular regulatory networks for future research on IMF traits in pigs, which can aid in improving pork quality through marker-assisted selection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Y. Y. Gao, G. Cheng, Z. X. Cheng, C. Bao, T. Yamada, G. F. Cao, S. Q. Bao, N. M. Schreurs, L. S. Zan, B. Tong
Summary: This study identified associations between genetic variants in FABP4, FASN, SCD, SREBP1, and TCAP genes and meat quality, carcass traits, and body size in Chinese Qinchuan cattle. The frequencies of certain alleles and genotypes differed significantly between Chinese cattle breeds and Korean or Japanese cattle. These polymorphisms could serve as genetic selection markers for desired traits in Qinchuan cattle.
Article
Food Science & Technology
Runqi Fu, Hengzhi Zhang, Daiwen Chen, Gang Tian, Ping Zheng, Jun He, Jie Yu, Xiangbing Mao, Zhiqing Huang, Junning Pu, Wenwu Yang, Bing Yu
Summary: This study investigated the effects of dietary betaine supplementation on the growth performance, meat quality, and muscle lipid metabolism of growing-finishing pigs. The results showed that betaine supplementation significantly increased average daily gain and tended to improve average daily feed intake and feed intake to gain ratio. Furthermore, betaine supplementation had effects on meat quality, intramuscular fat content, and lipid metabolism in pigs.
Article
Nutrition & Dietetics
Zhong Xu, Junjing Wu, Jiawei Zhou, Yu Zhang, Mu Qiao, Hua Sun, Zipeng Li, Lianghua Li, Nanqi Chen, Favour Oluwapelumi Oyelami, Xianwen Peng, Shuqi Mei
Summary: This study used ATAC-seq and RNA-seq analysis to examine the accessible chromatin and gene expression in Xidu black pigs, identifying key genes and regulatory pathways associated with meat quality and fat deposition.
FRONTIERS IN NUTRITION
(2022)
Article
Biotechnology & Applied Microbiology
Emma Sole, Rayner Gonzalez-Prendes, Yelyzaveta Oliinychenko, Marc Tor, Roger Ros-Freixedes, Joan Estany, Ramona N. Pena
Summary: Restricting dietary vitamin A during the fattening period did not improve intramuscular fat content, but there was an interaction between vitamin A and SCD genotype on the desaturation of fatty acids in muscle.
Article
Genetics & Heredity
Houssemeddine Srihi, Jose Luis Noguera, Victoria Topayan, Melani Martin de Hijas, Noelia Ibanez-Escriche, Joaquim Casellas, Marta Vazquez-Gomez, Maria Martinez-Castillero, Juan Pablo Rosas, Luis Varona
Summary: This study analyzed the hybrid pig breed CASTUA by estimating the additive and dominance variances, as well as the genetic correlations between purebred and crossbred populations. It identified four genomic regions associated with additive genetic variance in chromosomes 6, 8, and 12.
Article
Agriculture, Dairy & Animal Science
Eduard Molinero, Ramona N. Pena, Joan Estany, Roger Ros-Freixedes
Summary: In this study, a missense polymorphism in the AGPAT5 gene was found to be significantly associated with fat content and composition traits in pigs. The variant showed positive effects on intramuscular fat content and fatty acid composition. The impact of the variant on fat content was more pronounced in fatter pigs and it interacts with other genes that affect overall fatness.
Article
Agriculture, Dairy & Animal Science
Rafael Suarez-Mesa, Roger Ros-Freixedes, Houda Laghouaouta, Ramona N. Pena, Byron Hernandez-Ortiz, Iang Rondon-Barragan, Joan Estany
Summary: Dissecting genetic variation is important for conservation success. This study investigated the genomic variation of Colombian Creole pigs and identified breed-specific variants in genes related to adaptive and economic traits. The findings suggest that Colombian Creole pigs are not exempt from selective introgression of other breeds and provide insights for effective breeding and conservation.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2023)
Article
Genetics & Heredity
Sungbong Jang, Roger Ros-Freixedes, John M. Hickey, Ching-Yi Chen, William O. Herring, Justin Holl, Ignacy Misztal, Daniela Lourenco
Summary: This study investigated the strategies to combine large-scale data from different terminal pig lines in the multi-line genomic evaluation (MLE) using single-step GBLUP models. The use of unknown parent groups (UPG) and metafounders (MF) improved compatibility between pedigree and genomic relationships. Preselected sequence variants did not significantly improve multi-line genomic predictions, and weights from BayesR did not enhance the performance of ssGBLUP.
FRONTIERS IN GENETICS
(2023)
Article
Agriculture, Dairy & Animal Science
Houssemeddine Srihi, David Lopez-Carbonell, Noelia Ibanez-Escriche, Joaquim Casellas, Pilar Hernandez, Sara Negro, Luis Varona
Summary: INGA FOOD, S.A. conducted a crossbreeding program to produce hybrid pigs, and studies revealed differences in litter size between reciprocal crosses, suggesting the presence of genomic imprinting effects. A multivariate gametic model was introduced to estimate the gametic correlations between paternal and maternal effects from different genetic backgrounds. The results showed distinct differences in the posterior distribution of gametic correlations between the two populations, which may explain the performance outcomes in the reciprocal crosses.
Article
Genetics & Heredity
Carlos Hervas-Rivero, Houssemeddine Srihi, David Lopez-Carbonell, Joaquim Casellas, Noelia Ibanez-Escriche, Sara Negro, Luis Varona
Summary: This study conducted a genomic scan and identified eight genomic regions associated with inbreeding depression for litter size in two varieties of Iberian pigs. These regions contain relevant genes and suggest that the genetic determinism of inbreeding depression may be heterogeneous across the genome.
Article
Agriculture, Dairy & Animal Science
Ayman G. EL Nagar, Imen Heddi, Bolivar Samuel Sosa-Madrid, Agustin Blasco, Pilar Hernandez, Noelia Ibanez-Escriche
Summary: This study found that maternal genetic effects have an important impact on intramuscular fat content and fatty acid composition in rabbits. Through genome-wide association studies, potential candidate genes related to these traits were identified.
Article
Agriculture, Dairy & Animal Science
Sungbong Jang, Roger Ros-Freixedes, John M. Hickey, Ching-Yi Chen, Justin Holl, William O. Herring, Ignacy Misztal, Daniela Lourenco
Summary: This study investigated the impact of using preselected variants from whole-genome sequence (WGS) data on single-step genomic predictions in maternal and terminal pig lines. The results showed that using preselected SNP sets improved prediction accuracy in maternal lines but resulted in a decrease in accuracy in terminal lines. Therefore, the benefit of using WGS data depends on the line and the method of preselecting variants.
GENETICS SELECTION EVOLUTION
(2023)
Article
Agriculture, Dairy & Animal Science
Suzanne Desire, Martin Johnsson, Roger Ros-Freixedes, Ching-Yi Chen, Justin W. W. Holl, William O. O. Herring, Gregor Gorjanc, Richard J. J. Mellanby, John M. M. Hickey, Melissa K. K. Jungnickel
Summary: This study aimed to identify genomic regions associated with loin depth and muscle pH in pigs using GWAS and pCADD scores, and found two novel and one previously known associated regions. The study also showed mixed evidence for the utility of pCADD in fine-mapping. The next step is to perform more sophisticated fine-mapping and eQTL analysis, and validate candidate variants through perturbation-CRISPR assays.
GENETICS SELECTION EVOLUTION
(2023)
Article
Agriculture, Dairy & Animal Science
Roger Ros-Freixedes, Martin Johnsson, Andrew Whalen, Ching-Yi Chen, Bruno D. Valente, William O. Herring, Gregor Gorjanc, John M. Hickey
Summary: This study examined the use of whole-genome sequence data (WGS) for genomic prediction in pig lines and found that WGS did not significantly improve prediction accuracy compared to commercial marker arrays. However, larger training sets and optimized pipelines may lead to greater improvements in accuracy.
GENETICS SELECTION EVOLUTION
(2022)
Article
Agriculture, Dairy & Animal Science
Houda Laghouaouta, Lorenzo Fraile, Rafael Suarez-Mesa, Roger Ros-Freixedes, Joan Estany, Ramona Natacha Pena
Summary: This study provides new insights into the genetic make-up of resilience in growing pigs by identifying genomic regions and candidate genes associated with resilience indicators. The findings suggest that there are novel genomic regions associated with two resilience indicators (increment BW and increment HP) in pigs, which harbour potential candidate genes involved in immune response and growth pathways, highlighting the strong relationship between resilience and immune response.
GENETICS SELECTION EVOLUTION
(2022)
Article
Agriculture, Dairy & Animal Science
Roger Ros-Freixedes, Bruno D. Valente, Ching-Yi Chen, William O. Herring, Gregor Gorjanc, John M. Hickey, Martin Johnsson
Summary: In this study, whole-genome sequencing of commercial pig populations revealed that low-prevalence variants have low allele frequencies and limited contributions to phenotypic variance of production traits. Considering these low-prevalence variants is unlikely to significantly benefit across-breed genomic prediction.
GENETICS SELECTION EVOLUTION
(2022)