Article
Biology
Rania Elsabrouty, Youngah Jo, Seonghwan Hwang, Dong-Jae Jun, Russell A. DeBose-Boyd
Summary: UBIAD1 utilizes GGpp to synthesize vitamin K-2 and regulates sterol-accelerated ERAD. PDP1-mediated hydrolysis of GGpp significantly contributes to maintaining optimal intracellular levels of nonsterol isoprenoids.
Review
Biochemistry & Molecular Biology
Ainun Nizar Masbuchin, Mohammad Saifur Rohman, Ping-Yen Liu
Summary: Recent evidence has highlighted the importance of glycosylation in vascular calcification, involving N-glycosylation, O-glycosylation, and glycosylation mechanisms that lead to the formation of proteoglycans. This information reveals a close relationship between glycosylation and vascular calcification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Seongtae Jeong, Bok-Sim Lee, Seung Eun Jung, Yoojin Yoon, Byeong-Wook Song, Il-Kwon Kim, Jung-Won Choi, Sang Woo Kim, Seahyoung Lee, Soyeon Lim
Summary: Vascular calcification (VC) and osteoporosis are age-related diseases and share common risk factors such as renin-angiotensin system (RAS)-related hypertension. Inhibitors of RAS pathway, like angiotensin type 1 receptor blockers (ARBs), have shown potential in improving both conditions in the elderly. However, responsiveness to ARB treatment may differ based on gender, suggesting the need for alternative therapies. This study screened a natural compound library and found that citreoviridin (CIT) has potential as an effective therapeutic agent for both VC and osteoporosis by targeting osteoclast activation.
Article
Medicine, Research & Experimental
Guobin Zheng, Yun Zhao, Zhenhao Li, Yunqing Hua, Jing Zhang, Yaodong Miao, Yang Guo, Lan Li, Jia Shi, Zhengwei Dong, Shu Yang, Guanwei Fan, Chuanrui Ma
Summary: This study investigated the effects of Ganoderma lucidum spore powder (GLSP) on atherosclerosis and aortic calcification and revealed the underlying mechanism. The results showed that GLSP attenuated plaque area and aortic calcification by improving cholesterol efflux and inhibiting osteogenesis. The major components of GLSP triterpenes were found to promote cholesterol efflux and inhibit inflammation in macrophages, as well as inhibit osteogenesis in VSMC.
Article
Biochemistry & Molecular Biology
Weiping Zhang, Yong Sun, Youfeng Yang, Yabing Chen
Summary: Vascular calcification is accelerated in diabetic patients, leading to increased risk of cardiovascular events and mortality. This study investigates the role of STIM1, a regulator for intracellular calcium homeostasis, in diabetic vascular calcification and identifies the role of ER stress and protein O-GlcNAcylation in mediating this process.
Review
Cardiac & Cardiovascular Systems
Wenhong Jiang, Zhanman Zhang, Yaodong Li, Chuanzhen Chen, Han Yang, Qiuning Lin, Ming Hu, Xiao Qin
Summary: Arterial calcification is an abnormal deposition of calcium salts in the arterial wall, similar to physiological bone mineralization. Regulating the balance between osteoblast-like and osteoclast-like cells may be a promising therapeutic strategy against vascular calcification.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Geriatrics & Gerontology
Si-Chong Ren, Nan Mao, Si Yi, Xin Ma, Jia-Qiong Zou, Xiaoqiang Tang, Jun Ming Fan
Summary: Chronic kidney disease leads to vascular calcification, while aging and metabolic disorders are risk factors. Recent progress has been made in treating vascular calcification, but there is a lack of systematic reviews.
Article
Chemistry, Analytical
Nana Wang, Jiejun Wang, Pu Wang, Nan Ji, Shuhua Yue
Summary: Temozolomide (TMZ) is a first line chemotherapy drug for glioblastoma (GBM). However, GBMs without methylation of O-6-methylguanine-DNA methyltransferase (MGMT) show resistance to TMZ treatment. This study found that MGMT methylation affects lipid accumulation in GBM, and the amount and composition of lipid droplets (LDs) are significantly reduced in GBMs without MGMT methylation.
ANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Heng Li, Xiao-Hua Yu, Xiang Ou, Xin-Ping Ouyang, Chao-Ke Tang
Summary: NAFLD is a common chronic liver disease globally, with atherosclerotic cardiovascular disease being the leading cause of mortality in NAFLD patients. The liver plays a crucial role in cholesterol metabolism, and abnormal hepatic cholesterol metabolism can lead to NAFLD and drive the development of atherosclerosis.
PROGRESS IN LIPID RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Ploingarm Petsophonsakul, Mathias Burgmaier, Brecht Willems, Sylvia Heeneman, Nadina Stadler, Felix Gremse, Sebastian Reith, Kathrin Burgmaier, Florian Kahles, Nikolaus Marx, Ehsan Natour, Elham Bidar, Michael Jacobs, Barend Mees, Chris Reutelingsperger, Malgorzata Furmanik, Leon Schurgers
Summary: This study investigates the effects of nicotine on vascular smooth muscle cell calcification and its underlying mechanisms. The results show that calcification is more common in carotid plaques of smokers, and nicotine induces calcification and increases the expression of calcification-related genes and extracellular vesicle secretion in vascular smooth muscle cells. The pro-calcifying effects of nicotine are mediated by Ca2+-dependent Nox5, and Nox5 expression is higher in carotid arteries of smokers.
CARDIOVASCULAR RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Shuangshuang Wang, Siwang Hu
Summary: Vascular calcification is a common pathological change in many chronic diseases, but the exact mechanism of its pathogenesis is unclear. Sirtuins may play a protective role in VC and restoring their activity could be an effective treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Endocrinology & Metabolism
Min Li, Yi Zhu, Sandip Kumar Jaiswal, Nai-Feng Liu
Summary: Vascular calcification is highly prevalent and predicts adverse cardiovascular events. The pathogenesis of calcification is complex and incompletely characterized, with evidence showing that mitochondrial dysfunction may play a key role in vascular smooth muscle cells calcification. Metabolic regulation could be a potential therapeutic target in vascular calcification.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Hematology
Asier Benito-Vicente, Kepa B. Uribe, Asier Larrea-Sebal, Lourdes Palacios, Ana Cenarro, Xabier Calle, Unai Galicia-Garcia, Shifa Jebari-Benslaiman, Rosa M. Sanchez-Hernandez, Marianne Stef, Gilles Lambert, Fernando Civeira, Cesar Martin
Summary: This study extensively characterized the activities of L8 and L11 variants located in the signal peptide through in vitro experiments. It was found that the L11 variant enhances intracellular degradation of LDLr, which may lead to inefficient LDLr transport and LDLr degradation, resulting in mild hypercholesterolemia.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiaxin Chen, Hongjiao Yu, Xiao Tan, Simon Wing Fai Mok, Yuchen Xie, Yueheng Wang, Xueyan Jiang, Vicky E. Macrae, Lan Lan, Xiaodong Fu, Dongxing Zhu
Summary: The study investigates the role of PFKFB3, a critical enzyme of glycolysis, in vascular calcification and finds that its expression is upregulated in calcified mouse VSMCs and arteries. Overexpression of miR-26a/b-5p significantly inhibits PFKFB3 expression in VSMCs, and pharmacological inhibition of PFKFB3 or knockdown of PFKFB3 ameliorates vascular calcification in vivo or in vitro. The study suggests that PFKFB3 may be a promising therapeutic target for the treatment of vascular calcification.
Article
Multidisciplinary Sciences
Qi-Chao Yang, Shuo Wang, Yuan-Tong Liu, An Song, Zhi-Zhong Wu, Shu-Cheng Wan, Hui-Min Li, Zhi-Jun Sun
Summary: PCSK9 expression is upregulated in HNSCC tissues and higher expression is associated with poorer prognosis. Inhibition of PCSK9 suppresses cancer cell stemness via LDLR-dependent mechanism. PCSK9 inhibition enhances CD8(+) T cell infiltration, reduces MDSCs, and improves the efficacy of anti-PD-1 ICB therapy in HNSCC.