Article
Ophthalmology
Sobha Sivaprasad, Katie Banister, Augusto Azuro-Blanco, Beatriz Goulao, Jonathan A. Cook, Ruth Hogg, Graham Scotland, Heinrich Heimann, Andrew Lotery, Faruque Ghanchi, Richard Gale, Geeta Menon, Louise Downey, Nicola Hopkins, Peter Scanlon, Ben Burton, Craig Ramsay, Usha Chakravarthy
Summary: This study aimed to compare the diagnostic accuracy of routinely used tests of visual function and retinal morphology with FFA for detecting active macular neovascularization in patients with unilateral nAMD. Results showed that methods like self-reported vision changes, Amsler testing, visual acuity measurements, and fundus checks performed poorly in diagnosing active nAMD, while OCT demonstrated higher sensitivity and specificity.
Article
Multidisciplinary Sciences
Hidetaka Matsumoto, Junki Hoshino, Ryo Mukai, Kosuke Nakamura, Shoji Kishi, Hideo Akiyama
Summary: The phenotypes of neovascular age-related macular degeneration (nAMD) differ between Caucasian and Asian patients. This study focused on Japanese nAMD patients and found that type 1 macular neovascularization (MNV) and polypoidal choroidal vasculopathy (PCV) were the most common phenotypes. Pachychoroid, which is more prevalent in Asians, may contribute to the development of MNV in these patients.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Styliani Blazaki, Emmanouil Blavakis, Gregory Chlouverakis, Georgios Bontzos, Irini Chatziralli, Georgios Smoustopoulos, Eleni Dimitriou, Anastasios Stavrakakis, Stamatina Kabanarou, Tina Xirou, Demetrios G. Vavvas, Miltiadis K. Tsilimbaris
Summary: In this study, it was found that patients with neovascular AMD (nAMD) treated with anti-VEGF had a higher incidence and progression rate of macular atrophy (MA) compared to their fellow eyes with dry AMD (dAMD). However, if MA developed in the fellow dAMD eyes, it progressed faster over time compared to MA in nAMD eyes.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Biology
Oluchukwu Onwuka, Jackson L. Saddemi, Fatma Sema Akkan Aydogmus, Claudia C. Lasalle, David J. Ramsey
Summary: This study examined the relationship between the interval of monitoring the at-risk eyes of patients with unilateral neovascular age-related macular degeneration (nAMD) and the severity of the disease at diagnosis. The study compared the visual acuity and central macular thickness of patients who were actively receiving anti-VEGF treatment at the time of second eye diagnosis with patients who had discontinued treatment in their first eye. The results showed that the at-risk eyes of patients who had stopped treatment prior to fellow eye conversion were monitored less frequently than those who continued treatment. However, the visual acuity and central macular thickness were similar at the time of fellow eye diagnosis for both groups.
Article
Ophthalmology
Monica Lovestam Adrian, Marion Schroeder, Inger Westborg
Summary: This study analyzed the development of neovascular age-related macular degeneration (nAMD) in the fellow eye of patients initially presenting with unilateral nAMD, using data from the Swedish Macula Register. The results showed that a proportion of patients required bilateral treatment, with treatment of the fellow eye starting within approximately 2 years of the first eye's treatment. Best-corrected visual acuity in the second eye at the start of treatment was generally higher than that of the first eye.
ACTA OPHTHALMOLOGICA
(2022)
Article
Biochemistry & Molecular Biology
Daniel Rudolf Muth, Mario Damiano Toro, Anahita Bajka, Kamil Jonak, Roman Rieder, Myrtha Magdalena Kohler, Jeanne Martine Gunzinger, Eric H. Souied, Michael Engelbert, K. Bailey Freund, Sandrine Anne Zweifel
Summary: This study investigated the associations and predictive factors between different types of macular neovascularization (MNV) lesion variants and drusen types in patients with treatment-naive neovascular age-related macular degeneration (AMD). The findings suggest that subretinal drusenoid deposits (SDDs) are a common characteristic in AMD eyes with treatment-naive MNV, and the predominant drusen type may help predict the type of MNV that will develop.
Article
Ophthalmology
Assaf Hilely, Adrian Au, K. Bailey Freund, Anat Loewenstein, Eric H. Souied, Dinah Zur, Riccardo Sacconi, Enrico Borrelli, Enrico Peiretti, Claudio Iovino, Yoshimi Sugiura, Abdallah A. Ellabban, Jordi Mones, Nadia K. Waheed, Sengul Ozdek, Duygu Yalinbas, Sarah Thiele, Luisa Salles de Moura Mendonca, Mee Yon Lee, Won Ki Lee, Pierre Turcotte, Vittorio Capuano, Meryem Filali Ansary, Usha Chakravarthy, Albrecht Lommatzsch, Frederic Gunnemann, Daniel Pauleikhoff, Michael S. Ip, Giuseppe Querques, Frank G. Holz, Richard F. Spaide, SriniVas Sadda, David Sarraf
Summary: This study evaluated the patterns of subretinal fluid in eyes with non-neovascular AMD and found that SRF may be a result of RPE decompensation and RPE pump failure.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Wen-Chia Huang, Felice Cheng, Chia-Ching Chen, Po-Hsien Kuo, Yen-Jen Wang, Shao-Chan Yin, Chia-Mu Tu, Ming-Hsi Wu, Wen-Yu Wang, Sung-En Chen
Summary: The specially designed eye drop formulation demonstrated effective delivery of small-molecule VEGF inhibitor to posterior ocular tissues for antiangiogenic therapy, showing great promise in animal models.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Ophthalmology
Himeesh Kumar, Robyn H. Guymer, Lauren A. B. Hodgson, Xavier Hadoux, Zhichao Wu
Summary: The extent of reticular pseudodrusen (RPD) in individuals with intermediate age-related macular degeneration (AMD) has a significant impact on mesopic visual sensitivity. Eyes with larger drusen and coexistent RPD have reduced visual sensitivity, which worsens with an increasing extent of RPD. However, reduced sector-based visual sensitivities are mainly attributed to the overall extent of RPD presence, rather than their individual extent within a specific sector.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Review
Medicine, General & Internal
Daniele Veritti, Valentina Sarao, Valentina Soppelsa, Carla Danese, Jay Chhablani, Paolo Lanzetta
Summary: The use of anti-VEGF agents can significantly improve visual acuity in patients with nAMD, with a proactive treatment approach yielding better outcomes. Younger patients with lower baseline visual acuity and receiving a higher number of injections also have better treatment results.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Cumali Degirmenci, Filiz Afrashi, Semir Yarimada, Serap Bilge Ceper, Serhad Nalcaci, Cezmi Akkin, Jale Mentes
Summary: This study compared choroidal thickness, TCA, LA, SA, and CVI in patients with RPD and drusen. The results showed that patients with RPD had lower TCA, SA, and LA, indicating a decreased choroidal vasculature. These parameters can help evaluate the pathophysiology of the disease.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Malgorzata Wichrowska, Slawomir Liberski, Anna Rzeszotarska, Przemyslaw Wichrowski, Jaroslaw Kociecki
Summary: This study aimed to characterize the thickness of the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) in eyes affected by wet age-related macular degeneration (wAMD) treated with anti-VEGF, and compare it with the control group of eyes affected by early stages of dry age-related macular degeneration (dAMD). The study found that the GCL was thinner in the wAMD group compared to the dAMD group, while there were no significant differences in RNFL thickness. The number of injections received was found to have a significant correlation with layer thickness, and age over 73 was identified as a significant factor affecting RNFL thickness in both groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Hanna Helotera, Kai Kaarniranta
Summary: Age-related macular degeneration (AMD) is the leading cause of visual impairment in the aging population. It is classified into dry and neovascular forms, with neovascular AMD being associated with angiogenesis and inflammatory regulators.
Article
Ophthalmology
Clement K. Chan, Wesley T. Beaulieu, Brandon J. Lujan, Maziar Lalezary, Daniella Lent-Schochet, Therlinder Lo, Glenn Yiu
Summary: The purpose of this study was to investigate the impact of prophylactic ranibizumab injections on drusen volume, macular thinning, and GA progression in eyes with intermediate AMD. The results showed that prophylactic ranibizumab did not appear to affect these parameters. Additionally, there was no difference in the conversion rate to neovascular AMD between the PR and sham injection groups.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shruti Chandra, Manjot K. Grewal, Sarega Gurudas, Rajan Sondh, Alan Bird, Glen Jeffery, Victor Chong, Sobha Sivaprasad
Summary: The qAF8 levels in patients with non-neovascular AMD were found to be significantly lower compared to age-matched controls, indicating a early and sustained loss of function of the retinal pigment epithelium in AMD.