Article
Gastroenterology & Hepatology
Jung Ha Choi, Jeong Youp Park
Summary: The study demonstrated that a fluorescent IGF-1R-targeted antibody could aid in detecting gallbladder tumors, and tumor-specific imaging technology can be applied to endoscopy, laparoscopy, and robotic surgery for better management of gallbladder cancer.
Article
Immunology
Mihaly Balogh, Jixiang Zhang, Caitlyn M. Gaffney, Neha Kalakuntla, Nicholas T. Nguyen, Ronnie T. Trinh, Clarissa Aguilar, Hoang Vu Pham, Bojana Milutinovic, James M. Nichols, Rajasekaran Mahalingam, Andrew J. Shepherd
Summary: This study demonstrates that colon cancer is associated with latent sensory neuron dysfunction and implicates cytokine/chemokine signaling in this process. These findings may have implications for determining risk factors and treatment responsiveness related to neuropathy in colorectal cancer.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Pharmacology & Pharmacy
Guoliang Liu, Min Wang, Hongyu He, Jiannan Li
Summary: This study developed tumor-targeting nanoparticles loaded with doxorubicin for the treatment of colorectal cancer. The nanoparticles utilize a peptide, VATANST (STP), to achieve tumor-targeting effects, have a core-shell structure, and are sensitive to the tumor microenvironment. In vivo experiments in mice demonstrated the nanoparticles' properties as drug delivery systems and their good antitumor effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Yurong Song, Travis D. Kerr, Chelsea Sanders, Lisheng Dai, Shaneen S. Baxter, Brandon Somerville, Ryan N. Baugher, Stephanie D. Mellott, Todd B. Young, Heidi E. Lawhorn, Teri M. Plona, Bingfang Xu, Lei Wei, Qiang Hu, Song Liu, Alan Hutson, Baktiar Karim, Sandra Burkett, Simone Difilippantonio, Ligia Pinto, Johannes Gebert, Matthias Kloor, Steven M. Lipkin, Shizuko Sei, Robert H. Shoemaker
Summary: This study established organoids with MSI-H characteristics for studying MMR-deficient cancer biology and developed an orthotopic model suitable for evaluating the efficacy of neoantigen-based vaccines or anticancer drugs.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Shaobo Bai, Yang Sun, Ying Cheng, Weiliang Ye, Chenchao Jiang, Miao Liu, Qifeng Ji, Bangle Zhang, Qibing Mei, Daozhou Liu, Siyuan Zhou
Summary: PSVII@MCP-CaP, encapsulated in colon cancer targeting calcium phosphate nanoparticles, effectively inhibited the growth of drug-resistant colon cancer in nude mice by specifically accumulating in the cancer tissue and promoting apoptosis of cancer cells through mitochondria-mediated pathway. Additionally, it also inhibited invasion and migration of drug-resistant colon cancer cells by modulating protein expression related to cell adhesion and metastasis. This study suggests the potential of PSVII@MCP-CaP in treating drug-resistant colon cancer and introduces a new method for preparing targeted nanoparticles for insoluble compounds.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Immunology
Ofir Fursht, Mirit Liran, Yuval Nash, Vijay Krishna Medala, Dor Ini, Tabitha Grace Royal, Guy Goldsmith, Limor Nahary, Itai Benhar, Dan Frenkel
Summary: Inhibiting insulin-degrading enzyme (IDE) with an IDE-specific antibody shows promise in improving insulin activity in diabetes. Researchers have isolated an IDE-specific antibody that can specifically inhibit insulin degradation by IDE and demonstrated its efficacy in improving insulin activity in a diabetes mouse model.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yun Hee Sim, Yun Jung Um, Jeong-Yang Park, Min-Duk Seo, Sang Gyu Park
Summary: This study developed a novel anti-Nectin-2 antibody and an antibody-drug conjugate (c12G1-DM1) that exhibited potent cytotoxic effects against Nectin-2-positive ovarian cancer cells, suggesting its potential as a therapeutic agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Yuanbiao Tu, Zhihao Han, Rongbin Pan, Kuncheng Zhou, Ji Tao, Peifei Liu, Ray P. S. Han, Shuaichang Gong, Yueqing Gu
Summary: The novel peptide GB-6 labeled with NIR fluorescent dye and radionuclide technetium-99m showed efficient targeting to pancreatic cancer cells through the gastrin-releasing peptide receptor. It exhibited selective and specific uptake by tumors in vivo, allowing for clear tumor visualization and potential application in molecular-targeted therapy.
ANALYTICAL CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Boping Jing, Ruijie Qian, Dawei Jiang, Yongkang Gai, Zhen Liu, Feng Guo, Sen Ren, Yu Gao, Xiaoli Lan, Rui An
Summary: In this study, an extracellular vesicles-based nanoprobe was synthesized for visualizing colon cancer with PET/CT and NIRF imaging, showing promising results in preoperative evaluation and image-guided surgery in animal models. The nanoprobe showed a strong binding ability to tumor cells and achieved clear imaging results using PET/CT and NIRF imaging techniques. This study suggests the potential clinical application of extracellular vesicles as nanocarriers for multi-modal imaging and image-guided surgery of colon cancer.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Minxuan Xu, Jun Tan, Wei Dong, Benkui Zou, Xuepeng Teng, Liancai Zhu, Chenxu Ge, Xianling Dai, Qin Kuang, Shaoyu Zhong, Lili Lai, Chao Yi, Tingting Tang, Junjie Zhao, Longyan Wang, Jin Liu, Hao Wei, Yan Sun, Qiufeng Yang, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Mingxin Xiong, Jing Feng, Chufeng Zhang, Bochu Wang
Summary: This study reveals that Trim31 acts as an endogenous inhibitor of Rhbdf2 in mice, mitigating the development of NASH and potentially serving as a therapeutic target for treating NAFLD/NASH and associated metabolic disorders.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Johannes Linxweiler, Turkan Hajili, Philip Zeuschner, Michael D. Menger, Michael Stoeckle, Kerstin Junker, Matthias Saar
Summary: In this preclinical study, the effects of primary tumor resection on disease progression and survival in metastatic prostate cancer were analyzed using an orthotopic mouse model. The results showed that mice with primary tumor resection had slower PSA progression, fewer lung metastases, and longer survival compared to mice in the sham operation group. These findings suggest a potential beneficial oncological effect of primary tumor resection in metastatic prostate cancer. The established mouse model can also be used to study the molecular mechanisms of primary tumor/metastasis interaction in prostate cancer.
Article
Oncology
Seyda Berk, Joseph A. M. J. L. Janssen, Peter M. van Koetsveld, Fadime Dogan, Naci Degerli, Servet Ozcan, Fahrettin Kelestimur, Leo J. Hofland
Summary: The effects of glucose, insulin, and IGF on the growth of colon cancer cells vary between early and late stages. Glucose plays a more significant role in stimulating proliferation in early stage cells, while growth factor-mediated stimulation becomes more pronounced in late stage cells. Strict glucose control may be crucial in controlling tumor growth in early stages, while inhibiting the endocrine actions of IGFs and insulin is more important in late stages of colorectal cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ye Tian, Wei Lu, Ruicheng Shi, Reagan Mcguffee, Richard Lee, David A. Ford, Bo Wang
Summary: The study reveals that targeting LPCAT3 could be a novel therapy for insulin resistance, as suppression of Lpcat3 expression improves insulin sensitivity and metabolic issues in diabetic mice.
Article
Oncology
Elie Rassy, Layal Rached, Barbara Pistilli
Summary: The identification and development of HER-targeting antibody-drug conjugates (ADCs) have greatly improved the survival outcomes for breast cancer patients, particularly in the second and third-line settings. Despite promising activity in preclinical and clinical studies, there are still challenges to overcome, such as understanding resistance mechanisms and optimizing treatment for specific patient subgroups. Future research and clinical trials will help further enhance the efficacy of HER-targeting ADCs in breast cancer treatment.
Article
Engineering, Biomedical
Yiqun Ma, Liang Chen, Xilei Li, Annan Hu, Huiren Wang, Hao Zhou, Bo Tian, Jian Dong
Summary: A theranostic nanoplatform integrating multiple functions, including excellent targeting ability, dual-drug loading, photothermal therapy, and photoacoustic imaging, efficiently treats metastatic spinal tumors.
Article
Surgery
Min Je Sung, Jung Hyun Jo, Hee Seung Lee, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Si Young Song, Dong Jin Joo, Moon Jae Chung
Summary: The study compared the efficacy of FC-SEMS, PS, and PTBD for treating biliary strictures post-LDLT, showing that FC-SEMS group had better outcomes, PS group had lower functional resolution rate, and PTBD group had lower radiologic resolution rate.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Oncology
Ji Hoon Park, Jung Hyun Jo, Sung Ill Jang, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Si Young Song, Hee Seung Lee, Jae Hee Cho
Summary: This study investigated the proportion of BRCA 1/2 germline mutations in patients with pancreatic ductal adenocarcinoma (PDAC) and its impact on the response to FOLFIRINOX chemotherapy. The presence of germline BRCA 1/2 mutations was associated with a higher overall response rate in patients treated with FOLFIRINOX. The findings suggest that germline testing should be performed to predict treatment response in PDAC patients.
Article
Oncology
Jiyoung Keum, Hee Seung Lee, Jung Hyun Jo, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Seungmin Bang
Summary: This study aimed to investigate the association between UGT1A1 polymorphisms and FOLFIRINOX-induced neutropenia. The results showed that female sex, ECOG PS = 1, UGT1A1 IM, and UGT1A1 PM were independent risk factors for FN. It is recommended to screen UGT1A1 before chemotherapy.
Article
Oncology
Jung Hyun Jo, Dawoon E. Jung, Hee Seung Lee, Soo Been Park, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Sangsook Cho, Si Young Song
Summary: This phase I/II study evaluated the safety and efficacy of a new HDAC inhibitor called ivaltinostat in combination with gemcitabine and erlotinib for advanced PDAC. The study found that this combination therapy showed potential as a treatment option for PDAC.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Jung Ha Choi, Chang Moo Kang, Jeong Youp Park
Summary: This study demonstrates the use of the da Vinci system and Firefly camera in detecting fluorescently labeled EGFR antibodies in orthotopic mouse models of gallbladder cancer. The fluorescent EGFR antibodies enabled the visualization of gallbladder tumors, showing potential for molecular imaging-guided precision surgery in the future.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Se Woo Park, Kyong Joo Lee, Moon Jae Chung, Jung Hyun Jo, Hee Seung Lee, Jeong Youp Park, Seung Woo Park, Si Young Song, Huapyong Kang, Eui Joo Kim, Yeon Suk Kim, Jae Hee Cho, Seungmin Bang
Summary: This study compared the clinical outcomes of UCDBS and PCDBS for distal MBO. The results showed that PCDBS had a longer stent patency, but there were no significant differences between the two groups in overall survival and stent dysfunction.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Oncology
Huapyong Kang, Seung-seob Kim, Min Je Sung, Jung Hyun Jo, Hee Seung Lee, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Mi-Suk Park, Seungmin Bang
Summary: The suitability of the 8th edition AJCC staging system for clinical staging of pancreatic cancer remains uncertain. This study validated the prognostic performance and suitability of the current staging system and found that it is not validated for clinical staging. Separate criteria more suitable for clinical staging should be considered.
Article
Oncology
Chan Su Park, Min Je Sung, So Jeong Kim, Jung Hyun Jo, Hee Seung Lee, Moon Jae Chung, Seungmin Bang, Seung Woo Park, Si Young Song, Jeong Youp Park
Summary: This study aimed to explore the prognostic factors of pembrolizumab in patients with advanced biliary tract cancer (BTC) and provide treatment guidelines for patients who are refractory to gemcitabine-based chemotherapy. The results showed that high albumin levels and lymphocyte-to-monocyte ratio (LMR), as well as low alkaline phosphatase (ALP) levels and total bilirubin (TB), were significantly associated with better overall survival in patients treated with pembrolizumab.
Article
Oncology
Galam Leem, Sung-Ill Jang, Jae-Hee Cho, Jung Hyun Jo, Hee Seung Lee, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Da-Kyung Yoo, Hyo-Cheon Cheon, Jae-Eun Kim, Kyeong-Pill Lim, In-Hye Jung, Jung-Min Im, Yong-Yoon Chung, Seung Woo Park
Summary: This study investigated the safety and efficacy of allogeneic NK cells (SMT-NK) in combination with pembrolizumab in patients with chemotherapy-refractory advanced biliary tract cancer. The combination therapy showed improved efficacy compared to recent trials using pembrolizumab alone and provides a new possible treatment option for advanced biliary tract cancer patients.
Article
Gastroenterology & Hepatology
Sung Chan Kwon, Seungmin Bang, Young Nyun Park, Ji Hoon Park, So Jeong Kim, Jung Hyun Jo, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Eunhyang Park, Hee Seung Lee
Summary: This study found that PD-L1 expression in tumor cells is associated with poor prognosis in BTC patients, while PD-L1 expression in immune cells is beneficial for prognosis. There is a significant correlation between PD-L1 expression in tumor cells and immune cells and overall survival rates of patients.
Article
Endocrinology & Metabolism
Hee Seung Lee, Wonjeong Chae, Min Je Sung, Jiyoung Keum, Jung Hyun Jo, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Eun-Cheol Park, Chung Mo Nam, Sung-In Jang, Seungmin Bang
Summary: This study aimed to investigate the differences in incidence of pancreatic cancer between new-onset diabetes mellitus (NODM) and long-standing DM (LSDM). The results showed that the risk of pancreatic cancer was higher in the group with diabetes compared to the non-diabetes group, and the risk was higher in the NODM group than in the LSDM group, especially in men and patients in their 50s.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Huapyong Kang, Bora Lee, Jung Hyun Jo, Hee Seung Lee, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Si Young Song, Joonhyung Park, Hajin Shim, Jung Hyun Lee, Eunho Yang, Eun Hwa Kim, Kwang Joon Kim, Min-Soo Kim, Moon Jae Chung
Summary: A GBM ensemble model and LR model were developed and showed good potential for predicting and preventing hypoxaemia during ERCP under MAC.
YONSEI MEDICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Mi Ho Jeong, Taehwang Son, Yoo Keung Tae, Chan Hee Park, Hee Seung Lee, Moon Jae Chung, Jeong Youp Park, Cesar M. M. Castro, Ralph Weissleder, Jung Hyun Jo, Seungmin Bang, Hyungsoon Im
Summary: Cholangiocarcinoma (CCA) is a fatal disease often diagnosed at advanced stages. There is a lack of effective diagnostic methods or biomarkers for early detection of CCA. A nanoplasmonic sensing technology called FLEX is developed for sensitive and robust single extracellular vesicle (EV) analysis, which detected a wide heterogeneity of CCA-derived EVs and identified tumor markers in clinical bile samples. The FLEX assay showed better diagnostic performance than current clinical markers, offering a potential tool for early CCA diagnosis.
Review
Oncology
Dilmurodjon Eshmuminov, Botirjon Aminjonov, Russell F. Palm, Giuseppe Malleo, Ryan K. Schmocker, Raef Abdallah, Changhoon Yoo, Walid L. Shaib, Marcel Andre Schneider, Elena Rangelova, Yoo Jin Choi, Hongbeom Kim, J. Bart Rose, Sameer Patel, Gregory C. Wilson, Sarah Maloney, Lea Timmermann, Klaus Sahora, Fabian Rossler, Victor Lopez-Lopez, Emanuel Boyer, Laura Maggino, Thomas Malinka, Jeong Youp Park, Matthew H. G. Katz, Laura Prakash, Syed A. Ahmad, Scott Helton, Jin-Young Jang, Sarah E. Hoffe, Roberto Salvia, Julien Taieb, Jin He, Pierre-Alain Clavien, Ulrike Held, Kuno Lehmann
Summary: Pancreatic cancer often presents as locally advanced or borderline resectable. It is currently unclear which chemotherapy is preferred for patients in these categories. This study found that initial treatment with FOLFIRINOX appears to provide a survival benefit for patients that are ultimately unresectable, compared to gemcitabine-based chemotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Wonjeong Chae, Hee Seung Lee, Jung Hyun Jo, Moon Jae Chung, Seungmin Bang, Seung Woo Park, Si Young Song, Sung-In Jang, Jeong Youp Park
Summary: Gallbladder stones (GS) are associated with an increased risk of cardiovascular disease, but the relationship between cholecystectomy for GS and acute coronary syndrome (ACS) is unclear. In this study, the ACS risk in patients with GS and its association with cholecystectomy were investigated. The risk of ACS was higher in the GS group compared to the control group, and individuals without cholecystectomy in the GS group had a higher risk of ACS development. Cholecystectomy was associated with increased ACS risk in the gallstone group, especially in patients without metabolic disorders.
SCIENTIFIC REPORTS
(2023)