Article
Biochemistry & Molecular Biology
Chao Song, Dongmei Shi, Kaiwen Chang, Xianghui Li, Qing Dong, Xia Ma, Xuefei Wang, Zhenhuan Guo, Yonglu Liu, Jundong Wang
Summary: Fluoride-induced pulmonary toxicity is related to cell apoptosis, with activation of caspase-8 and induction of DR5 playing critical roles. NOX4 and p53 mediate the expression of DR5 induced by NaF, influencing pulmonary apoptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Anhui Yang, Ping Zhang, Zhen Sun, Xin Liu, Xinrui Zhang, Xingkai Liu, Di Wang, Zhaoli Meng
Summary: The study demonstrated that lysionotin exhibited significant anti-liver cancer effects by potentially involving the caspase-3 mediated mitochondrial apoptosis pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Ming Zhang, Jianmei Lai, Qianlong Wu, Jia Lai, Jingyao Su, Bing Zhu, Yinghua Li
Summary: Hepatocarcinoma is a common digestive system tumor worldwide with no effective treatment. Naringenin, isolated from citrus fruits, has shown anticancer effects. This study investigated the molecular mechanisms and oxidative stress implications of naringenin-induced cytotoxicity in HepG2 cells. Naringenin induced apoptosis in HepG2 cells through multiple pathways, enhanced cytotoxic effects, triggered reactive oxygen species, inhibited JAK-2/STAT-3 signaling pathways, and activated caspase-3. These findings suggest that naringenin could be a promising candidate for cancer therapy.
Article
Environmental Sciences
Cheng-Hsun Lin, Kuang-Hsuan Lin, Hsiang-Ju Ku, Kun-Ching Lee, Song-Shei Lin, Fei-Ting Hsu
Summary: Amentoflavone has been found to inhibit the progression of colorectal cancer through mechanisms such as triggering G1 arrest, DNA damage, and apoptosis, making it a potential treatment option.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vaikundamoorthy Ramalingam, Krishnamoorthy Varunkumar, Vilwanathan Ravikumar, Rajendran Rajaram
Summary: The present study investigates the effect and molecular mechanism of N-(2-hydroxyphenyl)-2-phenazinamine (NHP) from Nocardiopsis exhalans on human lung cancer cells. NHP exhibits excellent cytotoxic activity against A549 and H520 lung cancer cells at a concentration of 75 μg/mL, damaging the mitochondrial membrane and nucleus through oxidative stress. NHP causes nuclear condensation, induces apoptosis, down-regulates oncogenic genes, and upregulates apoptosis marker genes in lung cancer cells. NHP may have potential as an anticancer drug for lung cancer treatment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Neurosciences
Aziz Unnisa, Nigel H. H. Greig, Mohammad Amjad Kamal
Summary: Traumatic brain injury (TBI) is a major cause of death and morbidity, and is the focus of translational research. Apoptosis is important in the pathophysiology of TBI, and inhibiting it may improve functional recovery. Caspases, such as Caspase-3 and Caspase-9, are key mediators of cell death due to apoptosis in TBI. Understanding these apoptotic pathways and finding ways to inhibit Caspases may have significant treatment implications for TBI.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Rui Zan, Hao Wang, Weijie Cai, Jiahua Ni, Berengere J. C. Luthringer-Feyerabend, Wenhui Wang, Hongzhou Peng, Weiping Ji, Jun Yan, Jiazeng Xia, Yang Song, Xiaonong Zhang
Summary: The study shows that the release of hydrogen from magnesium-based biomaterial can increase the expression level of P53 proteins, thereby triggering apoptosis of tumor cells and suppressing tumor growth. The anti-tumor efficacy of magnesium-based biomaterials was confirmed in vivo in mice, with the minimal hydrogen concentration required for substantial tumor apoptosis found to be lower than that needed for hydrogen inhalation.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Giovanni Quarato, Fabien Llambi, Cliff S. Guy, Jaeki Min, Marisa Actis, Huan Sun, Shilpa Narina, Shondra M. Pruett-Miller, Junmin Peng, Zoran Rankovic, Douglas R. Green
Summary: The imbalance of intracellular Ca2+ and mitochondrial Ca2+ overload can lead to mitochondrial inner membrane permeabilization and cell death, which is distinct from Bcl-2 family-regulated mitochondrial outer membrane permeabilization. Cyclosporin A can prevent cell death by inhibiting Ca2+ release from endoplasmic reticulum stores.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Food Science & Technology
Sharifah Nadhira Syed Annuar, Nurul Farahana Kamaludin, Normah Awang, Kok Meng Chan
Summary: Di-and triphenyltin(IV) dithiocarbamate compounds show promising antiproliferative activity in K562 human erythroleukemia cells, inducing apoptosis through the intrinsic mitochondrial pathway and generating excessive intracellular reactive oxygen species.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Natsumi Fujiwara, Gary M. Whitford, John D. Bartlett, Maiko Suzuki
Summary: Curcumin can mitigate fluoride toxicity by modulating the p53-p21 pathway, inhibiting apoptosis induced by fluoride, and activating Akt to suppress fluoride-induced DNA damage.
ENVIRONMENTAL POLLUTION
(2021)
Article
Immunology
Jing Chen, Yi Zhou, Erpeng Zhu, Peng Yang, Mei Li, Shuangxiang Zhang, Jun Yue, Ming Wen, Kaigong Wang, Zhentao Cheng
Summary: The study reveals that MO infection induces time-dependent apoptosis in cultured MH-S cells, activating caspase-8-dependent extrinsic pathway and p53- and ROS-dependent intrinsic mitochondrial pathways. MO infection also enhances transcription and translation of proinflammatory cytokine genes, suggesting a potential link between MO-induced inflammation and apoptotic cell death.
Article
Cell Biology
Anil Khushalrao Shendge, Sourav Panja, Nripendranath Mandal
Summary: The study demonstrated the anticancer activity of tropical lichen DCME against brain and cervical cancer cells, revealing its cytotoxicity and apoptosis induction mechanisms through various experimental approaches.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Sayanta Dutta, Sushweta Mahalanobish, Sukanya Saha, Mullicka Mandal, Sanchari Begam, Pritam Sadhukhan, Sumit Ghosh, Goutam Brahmachari, Parames C. Sil
Summary: Selective initiation of programmed cell death in cancer cells was achieved by a synthetic bis-coumarin derivative 3 l, which demonstrated promising cytotoxic ability and apoptosis induction specifically in human renal carcinoma cells (SKRC-45). This compound modulated apoptotic pathways and inhibited NF-kappa B nuclear localization, resulting in reduced proliferation, survival, and migration ability of SKRC-45 cells. In an in vivo tumor model, 3 l exhibited an anticancer effect without affecting kidney function.
CELLULAR SIGNALLING
(2023)
Article
Immunology
Priyanka, Medha, Parul Bhatt, Hemant Joshi, Sadhna Sharma, Monika Sharma
Summary: Mitochondria are important for regulating cell fate, and Mycobacterium tuberculosis targets and controls host mitochondria for pathogenesis. In this study, the protein Rv0109 of Mtb was found to induce mitochondrial stress and apoptosis in macrophages.
MICROBIAL PATHOGENESIS
(2023)
Article
Multidisciplinary Sciences
Sirong Song, Dongbin Ma, Lixia Xu, Qiong Wang, Lanxiang Liu, Xiaoguang Tong, Hua Yan
Summary: Low-intensity pulsed ultrasound (LIPUS) can wake up glioma stem cells (GSCs) and enhance their sensitivity to chemotherapy. LIPUS weakens the Wnt and Hh signaling pathways, allowing GSCs to escape from quiescence, and triggers telomere crisis by converting oxygen molecules into singlet oxygen.
Article
Chemistry, Multidisciplinary
Nan Wang, Julian S. Evans, Jianhao Zhang, Chenxi Li, Sailing He
Summary: In a liquid crystal emulsion, chemically different guest phases reside in the topological disclinations of the host phase. These disclinations act as effective capillaries, leading to various meniscus and droplet phenomena. This demonstrates that anisotropic forces associated with liquid crystal molecules play a critical role in determining the shape and properties of a phase boundary.
MOLECULAR CRYSTALS AND LIQUID CRYSTALS
(2023)
Article
Chemistry, Physical
Hao Wu, Xiaoyu Cheng, Songjun Xie, Yan Huang, Raheel Ahmed Janjua, Xinzi Liu, Sailing He
Summary: This study presents a strategy to control the photoluminescence emission of aluminum quantum dots (AlQDs). It is found that surfactants and phosphonic acids (PAs) competitively bind to the surface of AlQDs, and this binding is affected by the space volume of surfactants and charge of head groups. The emission properties of AlQDs mainly originate from the surface-mediated states, and the red-shifting of the emission peak is a result of increased amount of PAs on the surface, possibly related to the surface oxygen presented in both ligands and surfactants. Overall, this study provides a method to control the photoluminescence of AlQDs by changing the surfactants and surface ligands, which has important implications for their applications in photonics, energy and environment, as well as biomedicine.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Multidisciplinary Sciences
Jing Chen, Yanxiao Zhao, Xuanjie Luo, Hao Hong, Tongqing Yang, Shen Huang, Chunli Wang, Hongyu Chen, Xin Qian, Mingfeng Feng, Zhengqiang Chen, Yongxin Dong, Zhenchuan Ma, Jia Li, Min Zhu, Sheng Yang He, Savithramma P. P. Dinesh-Kumar, Xiaorong Tao
Summary: Phytohormone signalling pathways play an important role in plant defence against pathogens. This study revealed that a pepper NLR protein Tsw interacts with a viral effector NSs to inhibit phytohormone receptor function, promoting virulence. Moreover, the plant has evolved a counter-virulence strategy by recognizing the interference of phytohormone signalling through a NLR protein with a structure resembling phytohormone receptors.
Correction
Multidisciplinary Sciences
Jing Chen, Yanxiao Zhao, Xuanjie Luo, Hao Hong, Tongqing Yang, Shen Huang, Chunli Wang, Hongyu Chen, Xin Qian, Mingfeng Feng, Zhengqiang Chen, Yongxin Dong, Zhenchuan Ma, Jia Li, Min Zhu, Sheng Yang He, Savithramma P. P. Dinesh-Kumar, Xiaorong Tao
Article
Materials Science, Multidisciplinary
Yuwei Sun, Zhipeng Hu, Kezhang Shi, Tingbiao Guo, Yuxin Xing, Yi Jin, Sailing He
Summary: Scientists demonstrate a resonant planar chiral dielectric metasurface design for circularly polarized emission (CPE). The design is easy to fabricate, with an extremely high and angle-insensitive far-field circular polarization degree. Experimental results show a 57-fold enhancement in photoluminescence from a thin film of PbS/CdS quantum dots coated on the metasurface, with a far-field degree of circular polarization as high as 0.74.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Optics
Yuting Zou, Zongxing Lin, Sailing He
Summary: This paper proposes a low-cross-talk and thermo-insensitive 1 x 4 coarse wavelength-division multiplexing device on the silicon-on-insulator platform. Compact Mach-Zehnder interferometers (MZIs) and slot waveguides are used to achieve wavelength-insensitive power splitting, while the trade-off between the opposite thermo-optical coefficients of the Si core and SU8 cladding is utilized to overcome the strong thermo-optic effect of silicon.
Article
Optics
Xiaoxuan Zheng, Zongxing Lin, Qiangsheng Huang, Sailing He
Summary: A novel structure utilizing a densely packed bent waveguide array is presented to eliminate mode hybridization in X-cut LiNbO3. The proposed structures show a polarization extinction ratio of -30 dB across all bend radii and low excess loss.
Article
Optics
Tie Zhang, Lihui Wang, Yan Huang, Haijie He, Sailing He, Gaoxuan Wang
Summary: A high-power near-infrared wavelength-modulated differential photoacoustic spectroscopy sensor has been developed for parts-per billion level methane detection using a homemade Raman fiber optical amplifier. Through the use of a commercial laser and specific techniques, the performance of the sensor is greatly improved, achieving a minimum detection limit of 10 ppb.
Article
Optics
Xiang Chen, Xuhui Huang, Sailing He
Summary: A four-dimensional hyperspectral surface topography measurement system is proposed to acquire three-dimensional spatial data and reflection/fluorescence spectra of an object. The system can assign spectral data to corresponding 3D point clouds, forming a 4D model. Experimental results demonstrate the great potential of the system in plant phenotype and growth analysis.
Article
Nanoscience & Nanotechnology
Nan He, Tingbiao Guo, Jiahan Tian, Ji Du, Zhipeng Hu, Yuxin Xing, Yi Jin, Junping Zhang, Sailing He
Summary: Free space optical communication (FSO) is gaining attention due to high information capacity demand. A novel duplex FSO system utilizing a compact fiber coupling metalens is demonstrated, achieving a large field of view and high coupling efficiency. The system shows excellent downlink/uplink communication performance with low bit error rate and clear eye diagram, meeting the requirements of smart devices.
Article
Chemistry, Multidisciplinary
Zhenjia Zeng, Lei Wang, Yiran Wu, Zhipeng Hu, Julian Evans, Xinhua Zhu, Gaoao Ye, Sailing He
Summary: This research explores the data shift challenge in AI-based electromagnetic solvers and proposes innovative solutions. The combination of mixed training and multi-head attention significantly reduces the mean absolute error of data affected by data shift.
Article
Chemistry, Multidisciplinary
Yiran Wu, Xinhua Zhu, Qiangsheng Huang, Yuan Zhang, Julian Evans, Sailing He
Summary: Fruit quality assessment is crucial for market value, consumer acceptance, and post-harvest management. Spectroscopic techniques have become popular for non-destructive evaluation. In this study, a deep-learning network called GCNN-LSTM-AT is proposed for predicting five important parameters of tangerines using visible and near-infrared spectroscopy. The proposed model combines GCN, CNN, LSTM, and attention mechanism to capture spatial and sequential dependencies and achieves accurate predictions for tangerine quality attributes exceeding other algorithms and models.
APPLIED SCIENCES-BASEL
(2023)
Article
Engineering, Electrical & Electronic
He Zhu, Jing Luo, Jiaqi Liao, Sailing He
Summary: In this paper, a hyperspectral transmission microscopic imaging (HTMI) system is developed for precise identification and classification of mixed pathogenic bacteria. The system has high spatial and spectral resolution, and achieves a high classification accuracy of 93.6% using a simple PCA-SVM method.
PROGRESS IN ELECTROMAGNETICS RESEARCH-PIER
(2023)
Article
Engineering, Electrical & Electronic
Haozhe Wang, Dawei Gong, Guokai Cheng, Jiang Jiong, Dun Wu, Xinhua Zhu, Shengnan Wu, Gaoao Ye, Lingling Guo, Sailing He
Summary: This paper proposes a high-temperature anomaly detection method based on SegFormer in the infrared image of power transmission and transformation equipment. By preprocessing and segmenting the infrared images, it can detect temperature anomalies in key parts and has important practical value.
PROGRESS IN ELECTROMAGNETICS RESEARCH M
(2023)
Article
Engineering, Electrical & Electronic
Jing Pan, Yuanqing Yao, Liu Yang, Hui Li, Sailing He
Summary: In this study, an optically transparent and flexible wideband antenna is proposed and experimentally demonstrated. The antenna is based on sub-micron thick micro-metallic meshes, which provide high visible transmittance and low sheet resistance. The antenna shows excellent comprehensive performance with superior transparency, radiation efficiency, and mechanical properties, making it suitable for practical applications and the emerging field of flexible and wearable electronics.
PROGRESS IN ELECTROMAGNETICS RESEARCH-PIER
(2023)