A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation

TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS

(2016) Ying Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury

(2016) Yali Zhang et al.   Scientific Reports

In vitro evaluation of TLR4 agonist activity: Formulation effects

(2013) Ayesha Misquith et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Adjuvants containing natural and synthetic Toll-like receptor 4 ligands

(2013) Gregory C Ireton et al.   Expert Review of Vaccines

Lessons Learned in Empirical Scoring with smina from the CSAR 2011 Benchmarking Exercise

(2013) David Ryan Koes et al.   Journal of Chemical Information and Modeling

Adjuvant formulation structure and composition are critical for the development of an effective vaccine against tuberculosis

(2013) Mark T. Orr et al.   JOURNAL OF CONTROLLED RELEASE

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

(2013) K. Katoh et al.   MOLECULAR BIOLOGY AND EVOLUTION

REVIEWING AND IDENTIFYING AMINO ACIDS OF HUMAN, MURINE, CANINE AND EQUINE TLR4 / MD-2 RECEPTOR COMPLEXES CONFERRING ENDOTOXIC INNATE IMMUNITY ACTIVATION BY LPS/LIPID A, OR ANTAGONISTIC EFFECTS BY ERITORAN, IN CONTRAST TO SPECIES-DEPENDENT MODULATION BY LIPID IVA

(2013) Thomas Scior et al.   Computational and Structural Biotechnology Journal

Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility

(2012) Tomoaki Nakamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural Analyses of Human Toll-like Receptor 4 Polymorphisms D299G and T399I

(2012) Umeharu Ohto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Respiratory Syncytial Virus Fusion Protein-Induced Toll-Like Receptor 4 (TLR4) Signaling Is Inhibited by the TLR4 Antagonists Rhodobacter sphaeroides Lipopolysaccharide and Eritoran (E5564) and Requires Direct Interaction with MD-2

(2012) P. Rallabhandi et al.   mBio

Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

(2012) Marcus D Hanwell et al.   Journal of Cheminformatics

Humanized TLR4/MD-2 Mice Reveal LPS Recognition Differentially Impacts Susceptibility to Yersinia pestis and Salmonella enterica

(2012) Adeline M. Hajjar et al.   PLoS Pathogens

Plant lectins are novel Toll-like receptor agonists

(2011) John Unitt et al.   BIOCHEMICAL PHARMACOLOGY

Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells

(2011) C. Russo et al.   BLOOD

Particulate vaccines: on the quest for optimal delivery and immune response

(2011) Marie-Luce De Temmerman et al.   DRUG DISCOVERY TODAY

GLA-SE, a Synthetic Toll-like Receptor 4 Agonist, Enhances T-Cell Responses to Influenza Vaccine in Older Adults

(2011) Hayedeh Behzad et al.   JOURNAL OF INFECTIOUS DISEASES

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant

(2011) Rhea N. Coler et al.   PLoS One

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

Use of defined TLR ligands as adjuvants within human vaccines

(2010) Malcolm S. Duthie et al.   IMMUNOLOGICAL REVIEWS

MD-2 Residues Tyrosine 42, Arginine 69, Aspartic Acid 122, and Leucine 125 Provide Species Specificity for Lipid IVA

(2010) Jianmin Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MD-2-mediated Ionic Interactions between Lipid A and TLR4 Are Essential for Receptor Activation

(2009) Jianmin Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

(2009) A. M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Hyaluronic acid fragments evoke Kupffer cells via TLR4 signaling pathway

(2009) JinXiang Zhang et al.   Science in China. Series C, Life sciences / Chinese Academy of Sciences

Differential Activation of Human and Mouse Toll-Like Receptor 4 by the Adjuvant Candidate LpxL1 of Neisseria meningitidis

(2008) L. Steeghs et al.   INFECTION AND IMMUNITY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

Synthetic tetra-acylated derivatives of lipid A from Porphyromonas gingivalis are antagonists of human TLR4

(2008) Yanghui Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY