Review
Cardiac & Cardiovascular Systems
Shuji Okahara, Bronwyn Levvey, Mark McDonald, Rohit D'Costa, Helen Opdam, David Pilcher, Gregory I. Snell
Summary: This retrospective study reviewed lung donor referrals between 2014 and 2018, finding main reasons for refusal to be lung quality issues, general medical issues, and organizational issues. Despite indications, the actual number of retrievable lungs through EVLP was limited.
ANNALS OF THORACIC SURGERY
(2021)
Review
Immunology
Nikhil K. Prasad, Chetan Pasrija, Tara Talaie, Alexander S. Krupnick, Yunge Zhao, Christine L. Lau
Summary: There is a significant shortage of donor organs for lung transplantation, and new strategies are needed to meet the growing global demand. Ex vivo lung perfusion has emerged as a powerful tool for evaluating and optimizing donor lungs before transplantation, providing exciting future opportunities for lung transplantation.
Review
Immunology
Jeeyeon Lee, Samuel J. Schellenberg, Liam Il-Young Chung, Ankit Bharat, Young Kwang Chae
Summary: Technological advances have improved the survival rate and expanded the indications for lung transplantation, including for COVID-19 patients. However, lung cancer patients have been excluded from transplantation despite comparable post-transplant survival rates to non-cancerous diseases. Double lung transplantation may be a potential treatment option for bilateral lung cancer patients with advanced respiratory insufficiency. This review examines the role of double lung transplantation in bilateral lung cancer.
TRANSPLANTATION REVIEWS
(2023)
Review
Gastroenterology & Hepatology
Scott L. L. Friedman, Arun J. J. Sanyal
Summary: The field of hepatology has made significant progress in understanding liver function, genetic determinants of disease, antiviral therapy, and transplantation in the past 75 years. However, challenges such as fatty liver diseases, autoimmune disease, cancer, and pediatric liver disease still need to be addressed. Diagnostic advances are urgently needed to improve risk stratification and testing of new agents. Integrated care models should be extended to address systemic manifestations and comorbidities. Expansion of the workforce and incorporating emerging skills in data management and precision medicine are necessary. Continued investment in science is crucial for further progress.
Article
Respiratory System
Mwelwa Chizinga, Tiago N. Machuca, Abbas Shahmohammadi, Divya C. Patel, Ayoub Innabi, Bashar Alzghoul, Vanessa Scheuble, Mauricio Pipkin, Borna Mehrad, Andres Pelaez, Christine Lin, Diana Gomez-Manjarres
Summary: This study found that there was no significant difference in 1-year survival between patients undergoing lung transplantation during AE-ILD and those transplanted with stable disease. Patients with AE-ILD who underwent transplantation had higher survival rates compared to those who were medically treated.
Article
Radiology, Nuclear Medicine & Medical Imaging
Francis T. Delaney, John G. Murray, Barry D. Hutchinson, Jim J. Egan, Michelle Murray, Sara Winward, Nicola Ronan, Carmel G. Cronin
Summary: The importance of lung cancer as a complication of lung transplantation is increasingly recognized. Radiology plays a key role in the assessment of lung cancer before and after transplantation. Chest CT can detect suspicious lung lesions and chronic lung structural diseases such as pulmonary fibrosis associated with an increased risk of malignancy after transplantation. However, the effectiveness of regular chest CT for lung cancer screening after transplantation needs further research.
EUROPEAN RADIOLOGY
(2022)
Review
Engineering, Biomedical
Alice L. L. Zhou, Emily L. L. Larson, Jessica M. M. Ruck, Jinny S. S. Ha, Alfred J. J. Casillan, Errol L. L. Bush
Summary: Lung transplantation is an effective treatment for end-stage lung disease, but the limited number of suitable organ donors restricts the number of transplants. Ex vivo lung perfusion (EVLP) has emerged as a solution by evaluating and improving the quality of marginal donor lungs and addressing logistical challenges. FDA-approved EVLP systems have shown excellent outcomes in clinical trials, with similar post-transplant survival compared to conventional methods. However, the high costs associated with initiating EVLP programs have hindered widespread utilization, and centralized EVLP perfusion centers are being investigated to expand its application.
Article
Cardiac & Cardiovascular Systems
Yuriko Terada, Tsuyoshi Takahashi, Ramsey R. Hachem, Jingxia Liu, Chad A. Witt, Derek E. Byers, Rodrigo Vazquez Guillamet, Hrishikesh S. Kulkarni, Ruben G. Nava, Benjamin D. Kozower, Bryan F. Meyers, Michael K. Pasque, G. Alexander Patterson, Daniel Kreisel, Varun Puri
Summary: This study analyzed a lung transplant database and found that some single lung transplants were performed after aborted double lung transplants, with acceptable long-term outcomes.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Editorial Material
Critical Care Medicine
Hakim Azfar Ali, Deborah Jo Levine
Summary: The volume and complexity of lung transplantation procedures have increased, leading to a greater demand for transplantation pulmonologists. However, current training methods are inadequate and vary in distribution and content. We discuss the current state of pulmonary LT training and advocate for the implementation of standardized curriculum and resource sharing.
Article
Critical Care Medicine
Kathleen J. Ramos, Jenna Sykes, Sanja Stanojevic, Xiayi Ma, Joshua S. Ostrenga, Aliza Fink, Bradley S. Quon, Bruce C. Marshall, Albert Faro, Kristofer Petren, Alexander Elbert, Christopher H. Goss, Anne L. Stephenson
Summary: The study revealed that among patients with FEV1 < 40% predicted, there are lower rates of lung transplant and an increased risk of death without lung transplant for US patients compared with Canadian patients. This difference is more significant among US patients with Medicaid/Medicare health insurance and nonwhite patients, suggesting potential disparities in access to lung transplants among vulnerable populations.
Review
Cardiac & Cardiovascular Systems
John E. McGinniss, Samantha A. Whiteside, Aurea Simon-Soro, Joshua M. Diamond, Jason D. Christie, Fredrick D. Bushman, Ronald G. Collman
Summary: Culture-independent study of the lower respiratory tract after lung transplantation has enabled an understanding of the dysbiotic lung microbiome, with specific features possibly linked to host responses and clinical outcomes such as chronic lung allograft dysfunction (CLAD), but many questions remain unanswered.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Travis D. Hull, Gregory A. Leya, Andrea L. Axtell, Philicia Moonsamy, Asishana Osho, David C. Chang, Thoralf M. Sundt, Mauricio A. Villavicencio
Summary: Restricted listing preference is associated with increased waitlist mortality, but DLT recipients have superior posttransplant survival.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Sayf A. Said, Toshihiro Okamoto, Amy S. Nowacki, Hiromichi Niikawa, Kamal S. Ayyat, Ichiro Sakanoue, James J. Yun, Kenneth R. McCurry
Summary: Blood transfusion from donors can increase recipient mortality, especially when more than 10 units are transfused.
ANNALS OF THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Adetola A. Kassim, Alexis Leonard
Summary: Hematopoietic stem cell transplantation is an effective treatment for SCD, but limited by the availability of matched sibling donors. Haploidentical HSCT and gene therapy show potential as alternative options, with expanded donor pool and improved outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Basheer Elsolh, Zubair Bayat, Dennis Lyu, Jules Lin, Elliot Wakeam
Summary: Through a review and pooled analysis, it was found that patients with incidentally removed NSCLC with earlier stage disease have better survival outcomes following LTx, especially for those with stage I disease.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
