Article
Gastroenterology & Hepatology
Maria Buti, Maria Stepanova, Adriana Palom, Mar Riveiro-Barciela, Fatema Nader, Luisa Roade, Rafael Esteban, Zobair Younossi
Summary: This study provides the first assessment of patient-reported outcomes in chronic hepatitis D (CHD) patients, showing significant impairment in some domains of health-related quality of life questionnaire compared to those with chronic hepatitis B (CHB). Further studies in larger cohorts with longer follow-up are needed to fully evaluate the impact of CHD on patient-reported quality of life.
Article
Gastroenterology & Hepatology
Mei Lu, Loralee B. Rupp, Christina Melkonian, Sheri Trudeau, Yihe G. Daida, Mark A. Schmidt, Stuart C. Gordon
Summary: This study found that pruritus is prevalent among patients with chronic hepatitis B and C, and it negatively affects their quality of life. The type of hepatitis and antiviral treatments do not seem to have a significant impact on pruritus severity, but antihistamines are associated with severe itch. Further treatment options are needed to address the impact of pruritus on quality of life in these patients.
LIVER INTERNATIONAL
(2023)
Article
Neurosciences
Tatiana Usnich, Bjoern Hauptmann, Henrike Hanssen, Jannik Prasuhn, Alexander Balck, Max Borsche, Vera Tadic, Annika Klee, Greta Noblejas-Sanchez, Eva-Juliane Vollstedt, Christine Klein, Norbert Brueggemann, Meike Kasten, EPIPARK Study Grp
Summary: Depressive symptoms in Parkinson's disease (PD) are multifactorial, including both dopaminergic deficit and chronic illness-related reactions. The prevalence and severity of depressive symptoms are similar between PD patients and disease controls (DC), though PD patients use antidepressants, especially Mirtazapine, more frequently. However, a significant proportion of patients in both groups with clinically significant depressive symptoms were not receiving medication. The diagnosis and treatment of depressive symptoms in both PD and DC should be improved.
NPJ PARKINSONS DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Savanna Plombon, Paul K. Henneberger, Michael J. Humann, Xiaoming Liang, Brent C. Doney, Kevin M. Kelly, Jean M. Cox-Ganser
Summary: This study found that working with crop storage insecticides or turkeys may increase the risk of chronic bronchitis, while working in hog or chicken confinement settings may increase the risk for airflow obstruction.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2022)
Article
Orthopedics
Dang-Huy Do, Angel A. Valencia, Chan-Hee Jo, Harry K. W. Kim
Summary: This study explores the impact of weightbearing and activity restrictions on the mental, social, and physical health of children aged 5 to 7 with Perthes disease. The results suggest that moderate restrictions are associated with worse depressive symptoms and anxiety, but not with anger, peer relationships, pain interference, and fatigue. These findings provide important guidance for providing appropriate mental health support and treatment recommendations.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2022)
Article
Respiratory System
Hyeon-Kyoung Koo, Karin F. Hoth, Barry J. Make, Elizabeth A. Regan, James D. Crapo, Edwin K. Silverman, Dawn L. DeMeo
Summary: This study aims to explore the association between optimism and disease-related characteristics in chronic obstructive pulmonary disease (COPD). The results showed that higher optimism was associated with fewer COPD exacerbations, better functional assessments, and higher quality of life. These findings further support the importance of cognitive behavioral therapy (CBT) in improving outcomes for COPD patients.
RESPIRATORY RESEARCH
(2022)
Article
Surgery
Ke Lang, Xiaocen Wang, Tingting Wei, Zhaolin Gu, Yansha Song, Dong Yang, Hao Wang
Summary: This study aimed to evaluate the impact of preoperative airflow obstruction on the prognosis of patients following surgery for esophageal carcinoma. The results showed that patients with airflow obstruction had lower survival rates than those without airflow obstruction. Multivariate analysis revealed that airflow obstruction was an independent risk factor for mortality in esophageal cancer patients.
FRONTIERS IN SURGERY
(2023)
Article
Multidisciplinary Sciences
Ana D. Jotic, Ana M. Opankovic, Zorana Z. Radin, Ljiljana Cvorovic, Katarina R. Savic Vujovic, Sanja B. Krejovic-Trivic, Bojana M. Bukurov, Biljana R. Milicic, Jasmina D. Stojanovic
Summary: The study found that in patients with chronic otitis media, 70.57% had some level of anxiety, 49.37% had some level of stress, and 13.29% had symptoms of depression. The severity of otitis media symptoms was significantly associated with patients' depression, anxiety, and stress levels.
Article
Psychology, Multidisciplinary
Ana Paula da Silva Ramos, Juliana Fernandes de Souza Ribeiro, Eduardo Tavares Lima Trajano, Marco Aurelio dos Santos Silva, Larissa Alexsandra da Silva Neto Trajano
Summary: This study assessed the levels of anxiety, depression, and quality of life in hospitalized men and women. The results showed that hospitalized women had higher levels of anxiety compared to men, but no difference was observed in the levels of depression. In terms of quality of life, women experienced more deterioration in general and mental health. Therefore, healthcare professionals should be aware of potential psychological changes in hospitalized women as they can significantly impact overall quality of life.
PSYCHOLOGICAL REPORTS
(2023)
Article
Clinical Neurology
Bernardo Cacho-Diaz, Ethan Gonzalez-Gonzalez, Andres Mauricio Bonilla-Navarrete, Julia Texcocano-Becerra, Luis F. Onate-Ocana
Summary: This study aimed to measure the impact of having clinically active neurologic symptoms on the quality of life of non-primary CNS cancer patients. The results showed that patients with neurologic symptoms had significantly worse perception in physical functioning, role functioning, emotional functioning, cognitive functioning, fatigue, nausea, pain, insomnia, appetite loss, and global health.
JOURNAL OF CLINICAL NEUROSCIENCE
(2023)
Article
Surgery
Jo Ellen Wilson, Myrick C. Shinall, Taylor C. Leath, Li Wang, Frank E. Harrell, Laura D. Wilson, Mina F. Nordness, Shayan Rakhit, Michael R. de Riesthal, Melissa C. Duff, Pratik P. Pandharipande, Mayur B. Patel
Summary: This study aimed to determine the health utility states of the Extended Glasgow Outcome Scale (GOSE) after traumatic brain injury (TBI) and found that some states were perceived as worse than death, highlighting unequal preferences for different levels of disability post-TBI.
Review
Urology & Nephrology
Rajiv Agarwal, James Burton, Maurizio Gallieni, Kamyar Kalantar-Zadeh, Gert Mayer, Carol Pollock, Jacek C. Szepietowski
Summary: Despite the limited increase in life expectancy for patients with end-stage kidney disease after the breakthrough of kidney replacement therapy, the quality of life and relief of symptoms have become increasingly important to patients. Currently, most dialysis-associated symptoms and adverse effects do not have approved treatments, and the few available treatments may add further adverse effects. This article demonstrates how understanding the pathophysiology of a particular symptom (chronic kidney disease-associated pruritus) in dialysis led to the development and regulatory approval of a treatment for that symptom. This approach can be applied to other dialysis-associated symptoms, improving the remaining years of patients' lives.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Transplantation
Murilo Guedes, Daniel Muenz, Jarcy Zee, Marcelo Barreto Lopes, Sandra Waechter, Benedicte Stengel, Ziad A. Massy, Elodie Speyer, Carole Ayav, Fredric Finkelstein, Ricardo Sesso, Ronald L. Pisoni, Bruce M. Robinson, Roberto Pecoits-Filho
Summary: The study found that low TSAT levels, as well as both low TSAT with low ferritin and low TSAT with high ferritin, are associated with worse physical HRQoL in NDD-CKD patients, even after accounting for Hb level. Interventional studies of iron therapy on HRQoL among NDD-CKD individuals are needed to confirm these findings.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Respiratory System
Joel Bergqvist, Mogens Bove, Anders Andersson, Linus Schioler, Geir Klepaker, Regine Abrahamsen, Anne Kristin M. Fell, Johan Hellgren
Summary: This prospective study found an association between chronic rhinosinusitis (CRS) and chronic bronchitis (CB). The study revealed that individuals who reported CRS had a significantly increased risk of developing CB after five years. It is important for physicians to be aware of the potential presence of chronic bronchitis in patients with CRS.
BMC PULMONARY MEDICINE
(2022)
Article
Multidisciplinary Sciences
L. Queneherve, D. Drui, J. Blin, M. Pere, E. Coron, G. Barbara, M. R. Barbaro, B. Cariou, M. Neunlist, D. Masson, K. Bach-Ngohou
Summary: Gastrointestinal symptoms are common in patients with chronic adrenal insufficiency, with a significant impact on quality of life. A considerable proportion of these patients meet the criteria for irritable bowel syndrome, and their overall quality of life is often described as poor or very poor.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Emily Chan Brodowsky, Akshay Sood, Mohit Butaney, Sami E. Majdalany, Alex Stephens, Nicholas Corsi, Austin J. Piontkowski, Ivan Rakic, Marcus Jamil, Deepansh Dalela, James O. Peabody, Craig G. Rogers, Firas Abdollah
Summary: The prognostic significance of a second biochemical recurrence (sBCR) after salvage radiation therapy (sRT) with/without hormonal therapy following primary radical prostatectomy has not been examined. The study found that a shorter time to sBCR is associated with worse cancer control outcomes. These findings are important for guiding subsequent treatments and counseling patients.
Article
Biochemistry & Molecular Biology
Xiaoran Li, Yanping Zhong, Xudong Zhang, Anil K. K. Sood, Jinsong Liu
Summary: By studying the dynamics of different cellular components during the formation of high-grade serous carcinoma organoids, we discovered that polyploid giant cancer cells (PGCCs) can develop through various modes of nuclear replication. PGCCs undergo processes like asymmetric mitosis, endoreplication, multipolar endomitosis, nuclear fusion, and karyokinesis without cytokinesis. This leads to an increase in nuclear contents and heterogeneity, resulting in the formation of complex tissue structures. These findings suggest that PGCCs play a central role in malignant histogenesis, intratumoral heterogeneity, immune escape, and macroevolution.
Article
Oncology
Patrick J. Hensley, Zhigang Duan, Kelly Bree, Akshay Sood, Hui Zhao, Niyati Lobo, Roberto Contieri, Matthew T. Campbell, Charles C. Guo, Neema Navai, Stephen B. Williams, Colin P. Dinney, Ashish M. Kamat
Summary: In this retrospective cohort study, we found that second primary nonurothelial cancers (SNUC) have a high incidence in patients with muscle-invasive bladder cancer (BC) who underwent radical cystectomy (RC). The most common SNUC types were lung cancer and colon cancer. Surveillance imaging for BC can aid in the early detection of SNUC.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Oncology
Katherine I. Foster, Kenna R. M. Shaw, Jeff Jin, Shannon N. Westin, Timothy A. Yap, Deanna M. Glassman, Amir A. Jazaeri, Jose A. Rauh-Hain, Sanghoon Lee, Bryan M. Fellman, Zhenlin Ju, Yuexin Liu, Nicole D. Fleming, Anil K. Sood
Summary: This study assessed the clinical relevance of tumor-based next-generation sequencing in patients with ovarian cancer. It found that tumor-based next-generation sequencing often provides clinically relevant information, helping to identify therapeutic targets and guide the development of clinical decision support tools.
Article
Biochemistry & Molecular Biology
Santosh K. K. Dasari, Robiya Joseph, Sujanitha Umamaheswaran, Lingegowda S. S. Mangala, Emine Bayraktar, Cristian Rodriguez-Aguayo, Yutuan Wu, Nghi Nguyen, Reid T. T. Powell, Mary Sobieski, Yuan Liu, Mamur A. A. Chowdhury, Paola Amero, Clifford Stephan, Gabriel Lopez-Berestein, Shannon N. N. Westin, Anil K. K. Sood
Summary: EphA2 tyrosine kinase is upregulated in many cancers and correlated with poor patient survival. A chemical screen identified Wee1 kinase inhibitor as a synergistic partner to EphA2-targeted therapeutics. Combination treatment showed enhanced anti-tumor response in endometrial cancer, suggesting the potential of Wee1 inhibition in improving EphA2-targeted therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Ophthalmology
Xiaole Li, Manav Nayeni, Monali S. S. Malvankar-Mehta
Summary: This study systematically compared different interventions for treating HSK and their patient outcomes. The results showed that corticosteroids and antivirals were most effective when used together. Oral acyclovir was as effective as its ointment counterpart. Tapering corticosteroid use and using it for at least 10 weeks could lead to greater therapeutic benefits. Anti-inflammatory drugs like flurbiprofen, cyclosporine-A, and tacrolimus were safe and effective for treating HSK. Long-term follow-up and randomized controlled trials could provide further insights on these potential alternatives.
OPHTHALMIC EPIDEMIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Piyush Aggarwal, Anupriya Anwariya, Anwin Joseph Kavanal, Ashwani Sood, Santosh Ranjan Jena, Bhagwant Rai Mittal
Summary: Peptide receptor radionuclide therapy (PRRT) is an effective treatment for patients with inoperable and/or metastatic neuroendocrine tumors that overexpress somatostatin receptor type 2 (SSTR-2). The post-therapy Lu-177-DOTATATE whole-body scan provides a comprehensive assessment of disease status and dosimetry, but it may also show abnormal radiotracer uptake that requires further imaging for accurate diagnosis. This report presents two cases of hot emboli in post-therapy Lu-177-DOTATATE scans, which has not been previously described.
NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ritanshu Solanki, Parikshaa Gupta, Ashwani Sood, Bhagwant Rai Mittal
Summary: This case report describes an unusual presentation of metastasis to the breast in addition to liver, pancreas, and lymph nodal metastases in a patient with ileal neuroendocrine tumor who was operated upon 5 years back. The metastases were detected by somatostatin receptor-based imaging and post-therapy scan confirmed by cytology and immunocytochemistry.
NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Meeting Abstract
Urology & Nephrology
Ivan Rakic, Matthew Davis, Nicholas Corsi, Alexander Stephens, Sohrab Arora, Nikola Rakic, Taylor Malchow, Chase Morrison, Rafe Affas, Akshay Sood, Craig Rogers, Firas Abdollah
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Ivan Rakic, Matthew Davis, Nicholas Corsi, Alexander Stephens, Sohrab Arora, Taylor Malchow, Rafe Affas, Akshay Sood, Alexander Cole, Quoc-Dienh Trinh, Firas Abdollah
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Akshay Sood, Jan Rudzinski, Alberto Martini, Come Tholomier, Sharada Mokkapati, Colin Dinney
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Akshay Sood, Ralph Grauer, Mireya Diaz-Insua, Firas Abdollah, Mani Menon
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Matthew Davis, Alexander Stephens, Sohrab Arora, Eric Williams, Chase Morrison, Nicholas Corsi, Ivan Rakic, Rafe Affas, Akshay Sood, Craig Rogers, Firas Abdollah
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Matthew Davis, Alexander Stephens, Chase Morrison, Sami Majdalany, Rafe Affas, Sohrab Arora, Nicholas Corsi, Ivan Rakic, Akshay Sood, Craig Rogers, Firas Abdollah
JOURNAL OF UROLOGY
(2023)
Article
Immunology
Esther Erdei, Xixi Zhou, Chris Shuey, Nour Ass'ad, Kimberly Page, Bobbi Gore, Chengsong Zhu, Deborah Kanda, Li Luo, Akshay Sood, Katherine E. Zychowski
Summary: The Southwestern United States has a long history of coal and metal mining, including uranium mining. Miners are at a high risk of lung diseases due to occupational dust exposure. However, there has been limited research on autoimmune biomarkers in miners, especially in relation to uranium exposure. This pilot study found significant associations between uranium mining exposure and certain biomarkers in the miners' serum.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2023)