Journal
PLANTA MEDICA
Volume 83, Issue 01-02, Pages 111-116Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0042-107252
Keywords
Delphinium ajacis; Ranunculaceae; diterpenoid alkaloid; anti-RSV activity
Categories
Funding
- Natural Science Foundations of China [81202429, 81273390, 81473116]
- Natural Science Foundation of Guangdong Province [S2013020012864]
- 111 Project [B13038]
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Five new diterpenoid alkaloids, ajacisines A-E (1-5), were isolated from Delphinium ajacis, along with seven known alkaloids (6-12). On the basis of their spectral data (IR, UV, HR-ESI-MS, 1D and 2D NMR) and chemical properties, the structures of compounds 1-12 were identified. All isolated compounds were evaluated for their in vitro antiviral activities against respiratory syncytial virus, and compounds 3-5 and 8 exhibited moderate to weak effects with IC50 values of 75.2 +/- 1.1, 35.1 +/- 0.6, 10.1 +/- 0.3, and 50.2 +/- 0.5 mu M, respectively.
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