Journal
PLANTA MEDICA
Volume 83, Issue 01-02, Pages 143-150Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0042-109778
Keywords
Piper flaviflorum; Piper sarmentosum; Piperaceae; amide alkaloids; antifungal activity
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Funding
- NSFC [81273408]
- Ministry of Science and Technology of China [2011CB915503]
- National Science and Technology Support Program of China [2013BAI11B02]
- Fourteenth Candidates of the Young Academic Leaders of Yunnan Province [2011CI044]
- West Light Foundation of the Chinese Academy of Sciences
- USDA Agricultural Research Service [58-6408-2-0009]
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Sixty-three amide alkaloids, including three new, piperflaviflorine A (1), piperflaviflorine B (2), and sarmentamide D (4), and two previously synthesized ones, (1E,3S)-1-cinnamoyl-3-hydroxypyrrolidine (3) and N-[7'-(4'-methoxyphenyl)ethyl]-2-methoxybenzamide (5), were isolated from the aerial parts of Piper flaviflorum and Piper sarmentosum. Their structures were elucidated by detailed spectroscopic analysis and, in case of 3, by single-crystal X-ray diffraction. Most of the isolates were tested for their antifungal and antibacterial activities. Ten amides (6-15) showed antifungal activity against Cryptococcus neoformans ATCC 90113 with IC50 values in the range between 4.7 and 20.0 mu g/mL.
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