Article
Biochemistry & Molecular Biology
Andrea Tagliani, Jacopo Rossi, Christophe H. Marchand, Marcello De Mia, Daniele Tedesco, Libero Gurrieri, Maria Meloni, Giuseppe Falini, Paolo Trost, Stephane D. Lemaire, Simona Fermani, Mirko Zaffagnini
Summary: The study focuses on the catabolism of GSNO in the microalga Chlamydomonas reinhardtii, identifying two enzymatic systems with specific reliance on NADPH or NADH, one of which is named CrGSNOR1. The kinetic properties and three-dimensional structures of CrGSNOR1 were determined, revealing its strict specificity towards GSNO and NADH, as well as its resistance to oxidative modifications.
Article
Biochemistry & Molecular Biology
Edoardo Jun Mattioli, Jacopo Rossi, Maria Meloni, Marcello De Mia, Christophe H. Marchand, Andrea Tagliani, Silvia Fanti, Giuseppe Falini, Paolo Trost, Stephane D. Lemaire, Simona Fermani, Matteo Calvaresi, Mirko Zaffagnini
Summary: S-nitrosylation plays an important role in cellular signaling by modulating protein function and conformation. This study investigates the molecular mechanisms of GSNO-dependent thiol oxidation using CrGAPA. The research reveals that GSNO induces reversible enzyme inhibition through S-nitrosylation, particularly at the catalytic Cys149, leading to CrGAPA inactivation.
Review
Biochemistry & Molecular Biology
Elena Kalinina, Maria Novichkova
Summary: S-glutathionylation and S-nitrosylation are reversible post-translational modifications on the cysteine thiol groups of proteins, important for regulating protein functional activity and cellular processes. The connection and switch functions between these modifications are performed by GSNO, dependent on factors like GSH content, GSH/GSSG ratio, and cellular redox state. Trx family enzymes play a crucial role in regulating these processes, with their activity determined by cellular redox status and GSH/GSSG ratio.
Article
Biotechnology & Applied Microbiology
E. Hounslow, C. A. Evans, J. Pandhal, T. Sydney, N. Couto, T. K. Pham, D. James Gilmour, P. C. Wright
Summary: Physiological and proteomic changes between two green alga strains, C. reinhardtii and C. nivalis, under salinity stress were characterized. Results showed that C. nivalis accumulated more carbohydrates and fatty acids under salt stress compared to C. reinhardtii. The differences in protein abundance provided insights into the mechanism by which salt stress promotes fatty acid accumulation in C. nivalis.
BIOTECHNOLOGY FOR BIOFUELS
(2021)
Review
Pharmacology & Pharmacy
Sicong Wang, Giovanna Di Trapani, Kathryn F. Tonissen
Summary: This review discusses the upregulation of Nrf-2 regulated antioxidant systems in lymphomas and their association with multiple signaling pathways involved in lymphoma development and progression. Targeting antioxidant systems, especially TrxR, may represent a new therapeutic approach for lymphoma.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Carla Umansky, Agustin E. Morellato, Matthias Rieckher, Marco A. Scheidegger, Manuela R. Martinefski, Gabriela A. Fernandez, Oleg Pak, Ksenia Kolesnikova, Hernan Reingruber, Mariela Bollini, Gerry P. Crossan, Natascha Sommer, Maria Eugenia Monge, Bjorn Schumacher, Lucas B. Pontel
Summary: Formaldehyde (FA) not only exerts cytotoxicity through DNA damage, but also triggers cellular redox imbalance by reacting with glutathione (GSH). GSH synthesis and the enzyme alcohol dehydrogenase 5 (ADH5) play crucial roles in preventing FA cytotoxicity. These findings are important for patients with mutations in FA detoxification systems and suggest potential therapeutic benefits of thiol-rich antioxidants.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Nolan T. Carew, Heidi M. Schmidt, Shuai Yuan, Joseph C. Galley, Robert Hall, Helene M. Altmann, Scott A. Hahn, Megan P. Miller, Katherine C. Wood, Bethann Gabris, Margaret C. Stapleton, Sean Hartwick, Marco Fazzari, Yijen L. Wu, Mohamed Trebak, Brett A. Kaufman, Charles F. McTiernan, Francisco J. Schopfer, Placido Navas, Patrick H. Thibodeau, Dennis M. McNamara, Guy Salama, Adam C. Straub
Summary: This study reveals the crucial role of cytochrome b5 reductase 3 (CYB5R3) in cardiomyocyte redox biology and identifies a common genetic variant that may increase the risk of death in Black patients with heart failure.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Judong Kim, S. M. Touhidul Islam, Fei Qiao, Avtar K. Singh, Mushfiquddin Khan, Jeseong Won, Inderjit Singh
Summary: The research shows that regulating the cytokines released by B cells can protect against neuroinflammatory diseases like experimental autoimmune encephalomyelitis. Using GSNO and GSNOR inhibitor N6022 can modulate IL-10 and IL-6, offering potential in treating autoimmune disorders.
Article
Plant Sciences
Marouane Ben Massoud, Oussama Kharbech, Lamia Sakouhi, Sihem Ben Hassine, Yao Zhu, Abdelilah Chaoui, David Sheehan, Wahbi Djebali
Summary: The study found that exogenous application of calcium or citrate can alleviate copper-induced toxicity in pea seedlings by reducing oxidative stress in root cells and balancing the levels of thiol-containing proteins. This is achieved through reducing copper accumulation in tissues and modulating the activities of various enzymes involved in glutathione and cysteine redox homeostasis. Additionally, calcium and citrate help regulate the thioredoxin and ferredoxin regeneration systems to maintain cellular redox balance under copper stress.
JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Nicholas J. Day, Matthew J. Gaffrey, Wei-Jun Qian
Summary: The review highlights how mass spectrometry-based redox proteomics has enabled accurate quantification of reversible oxidative modifications on specific cysteine residues of proteins, emphasizing the significance and application of such measurements in the field of redox biology.
Review
Plant Sciences
Maria Esther Perez-Perez, Stephane D. Lemaire, Jose L. Crespo
Summary: Autophagy is a crucial cellular pathway that maintains cellular homeostasis by removing damaged or unnecessary components. ATG4, as a key enzyme, plays an important role in regulating the biogenesis of autophagosomes.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Feng Liu, Penggang Han, Nuomin Li, Yongqian Zhang
Summary: This study investigated the role and underlying mechanisms of Ahp deficiency-induced cell damage in Escherichia coli. The results demonstrated that Ahp deficiency disrupted the redox balance, activated oxidative defense proteins and inhibited the TCA cycle. Surprisingly, the mutant strain shifted from aerobic respiration to anaerobic respiration and fermentation, and activated the acid resistance system to mitigate the effect of excessive acid produced by fermentation.
Article
Biochemistry & Molecular Biology
Feng Liu, Penggang Han, Nuomin Li, Yongqian Zhang
Summary: This study investigated the effects of alkyl hydroperoxide reductase (Ahp) deficiency in Escherichia coli (E. coli). The deficiency led to cellular damage, disruption of redox balance, activation of oxidative defense proteins, and inhibition of the TCA cycle. Surprisingly, the mutant strain shifted from aerobic respiration to anaerobic respiration and fermentation, activating the acid resistance system to mitigate the effect of excessive acid produced by fermentation.
Review
Biochemistry & Molecular Biology
Xiaolu Li, Tong Zhang, Nicholas J. J. Day, Song Feng, Matthew J. J. Gaffrey, Wei-Jun Qian
Summary: Protein S-glutathionylation (SSG) is a reversible post-translational modification that plays a critical role in redox signaling and regulation. This review summarizes current biochemical and analytical approaches for characterizing SSG and highlights recent examples of the functional and structural consequences of SSG modifications. The article also discusses future directions for research and the potential of computational methods in accelerating functional discovery.
Article
Biochemistry & Molecular Biology
Jiawen Li, Xiaomin Yang, Fuqing Liu, Xinxin Liu, Tong Zhao, Xiufeng Yan, Qiuying Pang
Summary: Salt stress can cause changes in redox modifications, which affect cell redox homeostasis and protein function. Eutrema salsugineum, a halophytic plant, has been used to study the role of redox modifications and signaling pathways in response to salt stress. This research provides a foundation for understanding the molecular mechanisms of plant salt response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agronomy
Rui-Ting Sun, Ze-Zhi Zhang, Xiang-Cao Feng, Nong Zhou, Hai-Dong Feng, Yi-Mei Liu, Wiwiek Harsonowati, Abeer Hashem, Elsayed Fathi Abd-Allah, Qiang-Sheng Wu
Summary: Inoculation with root endophytic fungi, especially Piriformospora indica, significantly promoted biomass production, physiological activities, and medicinal ingredient accumulation in Polygonum cuspidatum. The application of endophytic fungi increased resveratrol and polydatin concentrations, while affecting other compound concentrations in a complex manner.
Article
Multidisciplinary Sciences
Shahab Ali, Shujaul Mulk Khan, Zafar Siddiq, Zeeshan Ahmad, Khawaja Shafique Ahmad, Abdullah Abdullah, Abeer Hashem, Al-Bandari Fahad Al-Arjani, Elsayed Fathi Abd Allah
Summary: This study evaluated the carbon sequestration, diversity, and abundance of woody plants in the Margalla Hills National Park in Pakistan. The results showed that the park plays a significant role in carbon sequestration and has a rich diversity of woody plant vegetation.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Green & Sustainable Science & Technology
Syed Farhat Abbas, Muhammad Adnan Bukhari, Muhammad Aown Sammar Raza, Ghulam Hassan Abbasi, Zahoor Ahmad, Mashael Daghash Alqahtani, Khalid F. Almutairi, Elsayed Fathi Abd Allah, Muhammad Aamir Iqbal
Summary: Climate change and global warming have led to the need for biologically viable drought-mitigation strategies in wheat cultivation. This study tested two wheat cultivars subjected to different doses of ZnO nanoparticles before sowing. The results showed that ZnO nanoparticles, particularly at a 120 ppm dose under 100% field capacity, improved the growth and mineral contents of the wheat cultivars, making it a potential recommendation for wheat growers.
Article
Green & Sustainable Science & Technology
Shahab Ali, Shujaul Mulk Khan, Zeeshan Ahmad, Abdullah Abdullah, Naeemullah Kazi, Ismat Nawaz, Khalid F. F. Almutairi, Graciela Dolores Avila-Quezada, Elsayed Fathi Abd Allah
Summary: This study collected forest inventory data from 200 forest plots and found that relative humidity, elevation, and Coefficient of Variation of Diameter at breast height (CVD) significantly influence aboveground biomass (AGB) in different forest ecosystems. Relative humidity and soil phosphorus have a positive direct effect on AGB in multi-species forests, while elevation, CVD, and sunlight radiation (SR) negatively affect AGB.
Article
Green & Sustainable Science & Technology
Md. Salahuddin Kaysar, Uttam Kumer Sarker, Sirajam Monira, Md. Alamgir Hossain, Uzzal Somaddar, Gopal Saha, Apurbo Kumar Chaki, Abeer Hashem, Elsayed Fathi Abd Allah, Md Romij Uddin
Summary: The relationship between rice root morphology and potassium (K) has a significant impact on the growth and development of rice as well as its yield. In this study conducted at the net house of the Department of Agronomy at the Bangladesh Agricultural University, different rice varieties (Binadhan-10, Hira-2, and BRRI dhan29) were treated with different doses of K fertilizers. The results showed that the dose of 65 kg K ha(-1) significantly improved root traits and yield. However, further increase in K dosage did not lead to an increase in root traits and yield. A positive correlation was observed between yield and all root traits except root porosity. Therefore, a dose of 65 kg K ha(-1) can be recommended for satisfactory yield when cultivating Binadhan-10 at the field level.
Article
Agronomy
An-Qi Lei, Qing-Hua Yang, Ying Zhang, Wen-Yue Liao, Ya-Chao Xie, Anoop Kumar Srivastava, Abeer Hashem, Mashael Daghash Alqahtani, Elsayed Fathi Abd Allah, Qiang-Sheng Wu, Yi Zhang
Summary: This study analyzed the effects of Easily extractable glomalin-related soil protein (EEG) and found that it can improve soil fertility and fruit quality when used alone. However, when combined with agronomic practices, the positive effects of EEG may be reduced or suppressed.
Article
Agronomy
Md. Salahuddin Kaysar, Uttam Kumer Sarker, Sinthia Afsana Kheya, Ahmed Khairul Hasan, Md. Alamgir Hossain, Uzzal Somaddar, Gopal Saha, Apurbo Kumar Chaki, Abeer Hashem, Elsayed Fathi Abd-Allah, Md. Romij Uddin
Summary: Irrigation and fertilizer have significant effects on rice root traits and yield. A pot experiment was conducted in the boro season of 2021-2022 to investigate the effects of different irrigation, potassium, and nitrogen conditions on root parameters and yield of the rice variety Binadhan-10. The results showed that the saturation condition with K-65 and N-140 had the best performance in terms of root parameters, and grain yield was highest under this combination. Therefore, Binadhan-10 can be successfully cultivated with K-65 and N-140 under saturation conditions.
Article
Microbiology
Hilda Karina Saenz-Hidalgo, Juan Luis Jacobo-Cuellar, Erick Zuniga-Rodriguez, Graciela Dolores Avila-Quezada, Victor Olalde-Portugal, Abeer Hashem, Elsayed Fathi Abd Allah
Summary: This study aimed to determine the ectomycorrhizal colonization (ECM) percentage of pecan trees of different ages in conventional and organic agronomic orchards and to identify ectomycorrhizal sporocarps morphologically and molecularly. The ECM colonization percentage ranged from 31.44% to 59.89% and was higher in soils with low phosphorus content. The ECM concentrations were relatively consistent across tree ages, and organic matter content did not affect the ECM colonization percentage. Pisolithus arenarius and Pisolithus tinctorius fungi were molecularly identified as associated with pecan trees, with Pisolithus arenarius being reported for the first time.
Article
Horticulture
Vishal Singh Rana, Varsha Sharma, Sunny Sharma, Neerja Rana, Vijay Kumar, Umesh Sharma, Khalid F. Almutairi, Graciela Dolores Avila-Quezada, Elsayed Fathi Abd Allah, Kasahun Gudeta
Summary: This study investigated the impact of seaweed extract on the growth, yield, and quality of kiwifruit. The results showed that soaking the fruits in seaweed extract at a concentration of 3000 ppm after fruit set for 10 days significantly enhanced fruit growth and improved fruit quality.
Article
Green & Sustainable Science & Technology
Rigyan Gupta, Mohammad Joyel Sarkar, Md. Shafiqul Islam, Md. Romij Uddin, Israt Jahan Riza, Sirajam Monira, Farhana Zaman, Ahmed Khairul Hasan, A. K. M. Mominul Islam, Abeer Hashem, Graciela Dolores Avila-Quezada, Javid A. Parray, Elsayed Fathi Abd Allah, Uttam Kumer Sarker
Summary: In the hill regions of Bangladesh, where cultivable land is limited, efficient land use is necessary to increase crop output. Through a field experiment, incorporating mustard and mungbean into a rice-based cropping pattern was found to significantly improve yield and farmer income. The modified cropping pattern resulted in a higher rice equivalent yield compared to the existing cropping patterns, and the gross margin was significantly higher as well. Mustard and mungbean cultivation in hilly areas can bring quick economic returns and may be introduced on a large scale in Khagrachhari district.
Article
Agronomy
Shivender Thakur, A. K. Sharma, Kuldeep Thakur, Sunny Sharma, Kasahun Gudeta, Abeer Hashem, Graciela Dolores Avila-Quezada, Nadine M. S. Moubayed, Elsayed Fathi Abd Allah
Summary: The present study aimed to investigate the differential responses to assimilated nutrient management in the cabbage-capsicum-radish cropping system. It was found that using 75% NP + VC and EC, along with 5 kg/ha of PGPR, significantly improved the growth and yield of cabbage, while the T-14 treatment module demonstrated superior performance in terms of yield components for capsicum.
Article
Agronomy
Mouna Mechri, Khedija Bouajila, Noura Ziadi, Taqi Raza, Hayet Beltayef, Neal S. Eash, Naceur Jedidi, Azaiez Gharbi, Abeer Hashem, Elsayed Fathi Abd-Allah
Summary: In Tunisia, climate change impacts and intensive plowing and cultivation practices used by Tunisian farmers have led to the degradation of soil resources, affecting socio-economic development. A study conducted in Le Krib, Tunisia, evaluated the effects of different cropping systems and tillage types on soil aggregates and physio-chemical properties, as well as carbon and nitrogen concentrations. The results showed that soil carbon content was influenced by interactions between previous crops and tillage regimes, while nitrogen concentrations varied with previous crops and tillage types.
Article
Microbiology
Priya Yadav, Rahul Prasad Singh, Abeer Hashem, Elsayed Fathi Abd Allah, Gustavo Santoyo, Ajay Kumar, Rajan Kumar Gupta
Summary: There is a growing interest in utilizing cyanobacteria for land rehabilitation. This study evaluated the ability of different cyanobacteria and their consortia to form biocrusts on different substrates, and found that the consortium exhibited better results. The study also showed that cyanobacteria can persist in soil environments and have positive impacts on soil fertility and plant growth.
Article
Environmental Sciences
Kanwaljit Kaur Ahluwalia, Kritika Thakur, Amrik Singh Ahluwalia, Abeer Hashem, Graciela Dolores Avila-Quezada, Elsayed Fathi Abd Allah, Neelam Thakur
Summary: This study evaluated the genotoxicity of zinc oxide nanoparticles in mosquitoes, and found that exposure to a dose below LD20 resulted in chromosomal aberrations, abnormal sperm head shapes, and dominant lethal mutations. This indicates the potential genotoxicity of zinc oxide nanoparticles and highlights the need for environmental and biological protection.
Article
Biology
Ming-Ao Cao, Fei Zhang, Elsayed Fathi Abd Allah, Qiangsheng Wu
Summary: In this study, a potted experiment was conducted to investigate the effects of arbuscular mycorrhizal fungi on the antioxidant defense system of Satsuma orange under cold stress. The results showed that inoculation with these fungi enhanced the cold resistance of the plants by regulating the activity and gene expression levels of antioxidant enzymes. This study highlights the importance of mycorrhizal fungi in improving plant tolerance to cold stress.