Root regulation of artemisinin production in Artemisia annua: trichome and metabolite evidence

Transcriptional regulation of artemisinin biosynthesis in Artemisia annua L.

(2016) Qian Shen et al.   Science Bulletin

Variations in key artemisinic and other metabolites throughout plant development in Artemisia annua L. for potential therapeutic use

(2015) Melissa J. Towler et al.   INDUSTRIAL CROPS AND PRODUCTS

The activity of the artemisinic aldehyde Δ11(13) reductase promoter is important for artemisinin yield in different chemotypes of Artemisia annua L.

(2015) Ke Yang et al.   PLANT MOLECULAR BIOLOGY

Arbuscular mycorrhiza increase artemisinin accumulation in Artemisia annua by higher expression of key biosynthesis genes via enhanced jasmonic acid levels

(2014) Shantanu Mandal et al.   MYCORRHIZA

Differential transcriptome analysis of glandular and filamentous trichomes in Artemisia annua

(2013) Sandra SA Soetaert et al.   BMC PLANT BIOLOGY

A rapid method for the determination of artemisinin and its biosynthetic precursors in Artemisia annua L. crude extracts

(2013) John Suberu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The metabolite chemotype ofNicotiana benthamianatransiently expressing artemisinin biosynthetic pathway genes is a function ofCYP71AV1type and relative gene dosage

(2013) Hieng-Ming Ting et al.   NEW PHYTOLOGIST

Don’t kill the messenger: Long-distance trafficking of mRNA molecules

(2013) Ziv Spiegelman et al.   PLANT SCIENCE

Loss of artemisinin produced by Artemisia annua L. to the soil environment

(2012) Karina K. Jessing et al.   INDUSTRIAL CROPS AND PRODUCTS

Development of artemisinin compounds for cancer treatment

(2012) Henry C. Lai et al.   INVESTIGATIONAL NEW DRUGS

Antiplasmodial activity of flavonol quercetin and its analogues in Plasmodium falciparum: evidence from clinical isolates in Bangladesh and standardized parasite clones

(2012) Deepa Ganesh et al.   PARASITOLOGY RESEARCH

The effect of roots and media constituents on trichomes and artemisinin production in Artemisia annua L.

(2012) Khanhvan T. Nguyen et al.   PLANT CELL REPORTS

The Flavonoids Casticin and Artemetin Are Poorly Extracted and Are Unstable in an Artemisia annua Tea Infusion

(2012) Pamela Weathers et al.   PLANTA MEDICA

Metabolic engineering of flavonoids in plants and microorganisms

(2011) Yechun Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.

(2011) Khanhvan T. Nguyen et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT

The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)

(2010) Geoffrey D. Brown   MOLECULES

Flavonoids from Artemisia annua L. as Antioxidants and Their Potential Synergism with Artemisinin against Malaria and Cancer

(2010) Jorge F.S. Ferreira et al.   MOLECULES

Dissection of the phytohormonal regulation of trichome formation and biosynthesis of the antimalarial compound artemisinin in Artemisia annua plants

(2010) Lies Maes et al.   NEW PHYTOLOGIST

The production of artemisinin precursors in tobacco

(2010) Yansheng Zhang et al.   PLANT BIOTECHNOLOGY JOURNAL

Enhancement of artemisinin content and biomass in Artemisia annua by exogenous GA3 treatment

(2010) Waleerat Banyai et al.   PLANT GROWTH REGULATION

Reproductive Development Modulates Gene Expression and Metabolite Levels with Possible Feedback Inhibition of Artemisinin in Artemisia annua

(2010) P. R. Arsenault et al.   PLANT PHYSIOLOGY

The Molecular Cloning of Dihydroartemisinic Aldehyde Reductase and its Implication in Artemisinin Biosynthesis inArtemisia annua

(2010) Anna-Margareta Rydén et al.   PLANTA MEDICA

The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin

(2010) I. A. Graham et al.   SCIENCE

Prediction of DNA-binding residues from protein sequence information using random forests

(2009) Liangjiang Wang et al.   BMC GENOMICS

Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annuaThis paper is one of a selection of papers published in a Special Issue from the National Research Council of Canada – Plant Biotechnology Institute.

(2009) Keat H. Teoh et al.   Botany

Anticancer activities of artemisinin and its bioactive derivatives

(2009) Gary L. Firestone et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L.

(2009) Mikael E. Olsson et al.   PHYTOCHEMISTRY

Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study

(2009) Nicholas Schramek et al.   PHYTOCHEMISTRY

DMSO triggers the generation of ROS leading to an increase in artemisinin and dihydroartemisinic acid in Artemisia annua shoot cultures

(2009) Abdul Mannan et al.   PLANT CELL REPORTS

The Molecular Cloning of Artemisinic Aldehyde Δ11(13) Reductase and Its Role in Glandular Trichome-dependent Biosynthesis of Artemisinin inArtemisia annua

(2008) Yansheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Making artemisinin☆

(2008) Patrick S. Covello   PHYTOCHEMISTRY