Review
Endocrinology & Metabolism
Mathias Brown Pedersen, Stefan Dukanovic, Jacob Bertram Springborg, Mikkel Andreassen, Jesper Krogh
Summary: The effects of transsphenoidal surgery on pituitary endocrine function in patients with NFPAs are uncertain. The chance of recovery and the risk of pituitary failure and hypopituitarism are unclear. Further systematic data collection is needed for a better understanding.
NEUROENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Georgios Mantziaris, Stylianos Pikis, Tomas Chytka, Roman Liscak, Kimball Sheehan, Darrah Sheehan, Selcuk Peker, Yavuz Samanci, Shray K. Bindal, Ajay Niranjan, L. Dade Lunsford, Rupinder Kaur, Renu Madan, Manjul Tripathi, Dhiraj J. Pangal, Ben A. Strickland, Gabriel Zada, Anne-Marie Langlois, David Mathieu, Ronald E. Warnick, Samir Patel, Zayda Minier, Herwin Speckter, Zhiyuan Xu, Rithika Kormath Anand, Jason P. Sheehan
Summary: This study analyzed 375 patients with residual nonfunctioning pituitary adenomas (NFPAs) who were treated with stereotactic radiosurgery (SRS) and compared the outcomes between early treatment and treatment at progression. The results showed that there was no significant difference in tumor control and preservation of hormonal/visual function between SRS at residual NFPA progression and adjuvant SRS. Deferring radiosurgical management to the time of radiological progression could prolong the onset of radiosurgically induced pituitary dysfunction.
JOURNAL OF NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Jiayin Qin, Kai Li, Xijuan Wang, Yongzhen Bao
Summary: This study aimed to investigate the differences in visual impairment caused by functioning and non-functioning pituitary adenomas. It was found that patients with functioning pituitary adenomas had better corrected visual acuity and lighter visual field defects compared to those with non-functioning pituitary adenomas. Additionally, tumor volume was correlated with visual field defects in both groups.
Article
Medicine, General & Internal
Carlos Perez-Lopez, Cristina Alvarez-Escola, Alberto Isla Guerrero
Summary: The treatment of non-functioning pituitary adenomas depends on symptoms, contact with the optic tract, and growth on imaging tests. Medical treatment is used after surgical and radiotherapy options are exhausted.
Article
Endocrinology & Metabolism
C. Vivancos Sanchez, A. Palpan Flores, V. Rodriguez Dominguez, A. Zamarron Perez, C. Alvarez-Escola, C. Perez Lopez
Summary: Younger age, smaller preoperative tumor volume, and undergoing gross total resection are associated with better hormonal function improvement postoperatively, while pituitary gland visualization is related to better hormonal outcomes in patients.
Article
Endocrinology & Metabolism
Ross Hamblin, Athanasios Fountas, Kirstie Lithgow, Paul Benjamin Loughrey, Efstathios Bonanos, Shah Khalid Shinwari, Kirsten Mitchell, Syed Shah, Lydia Grixti, Mike Matheou, Kristina Isand, David S. McLaren, Ashutosh Surya, Hafiz Zubair Ullah, Katarina Klaucane, Anuradha Jayasuriya, Sumbal Bhatti, Akash Mavilakandy, Masato Ahsan, Susan Mathew, Ziad Hussein, Thijs Jansz, Wunna Wunna, James MacFarlane, John Ayuk, Prakash Abraham, William M. Drake, Mark Gurnell, Antonia Brooke, Stephanie E. Baldeweg, Amir H. Sam, Niamh Martin, Claire Higham, Narendra Reddy, Miles J. Levy, Rupa Ahluwalia, John Newell-Price, Joannis Vamvakopoulos, Amutha Krishnan, Andrew Lansdown, Robert D. Murray, Aparna Pal, Karin Bradley, Yaasir Mamoojee, Tejpal Purewal, Janki Panicker, E. Marie Freel, Faisal Hasan, Mohit Kumar, Biju Jose, Steven J. Hunter, Niki Karavitaki
Summary: This study provides evidence on the natural history of non-functioning pituitary microadenomas (micro-NFPAs) and suggests that the probability of micro-NFPA growth is low, and the development of new hypopituitarism is rare. Delaying the first follow-up MRI to 3 years and avoiding hormonal re-evaluation in the absence of tumor growth or clinical manifestations is a safe approach for micro-NFPA surveillance.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Reem Al Argan, Abdulaziz Ramadhan, Ramanakumar Agnihotram, Jeffrey Chankowsky, Juan Rivera
Summary: Hypopituitarism is more likely to occur in large pituitary adenomas, with different hormonal deficiencies. In this study of NFPA patients, MRI characteristics were used to predict SAI and CHT. Factors such as age, sex, tumor size, invasiveness, and optic chiasma compression were associated with SAI/CHT.
ENDOCRINE CONNECTIONS
(2021)
Article
Oncology
Ziad Hussein, Robert W. Slack, Hani J. Marcus, Evangelos B. Mazomenos, Stephanie E. Baldeweg
Summary: Non-functioning pituitary adenomas (NFPAs) can lead to hypopituitarism, and this condition may persist after surgery or radiotherapy. Predicting post-intervention hypopituitarism is challenging, but this study utilized machine learning models to improve prediction accuracy up to 15 years after surgical intervention. Pre-operative hormone levels were found to be the best predictor for hypopituitarism within the first year, while endocrine tests conducted within the same period supported strong predictions for 5 and 10 years post-operatively.
Article
Clinical Neurology
Yasuyuki Kinoshita, Akira Taguchi, Atsushi Tominaga, Kazunori Arita, Fumiyuki Yamasaki
Summary: Recovery from AGHD after initial TSS is more likely in younger female patients with higher peak GH levels assessed by preoperative PPT. Patients aged <= 62.2 years and with a peak GH level of >= 0.74 μg/L based on preoperative PPT are likely to recover from AGHD.
JOURNAL OF NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Friso de Vries, Daniel J. Lobatto, Marco J. T. Verstegen, Pieter J. Schutte, Irene C. Notting, Mark C. Kruit, S. Faisal Ahmed, Alberto M. Pereira, Wouter R. van Furth, Nienke R. Biermasz
Summary: Transsphenoidal surgery is the standard treatment for hormone-secreting pituitary adenomas. This study proposes a novel way to classify and report surgical outcomes by integrating efficacy and safety at the patient level. The results show that surgical interventions can be presented in four categories, incorporating both efficacy and safety.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Friso de Vries, Daniel J. Lobatto, Marco J. T. Verstegen, Pieter J. Schutte, Irene C. Notting, Mark C. Kruit, S. Faisal Ahmed, Alberto M. Pereira, Wouter R. van Furth, Nienke R. Biermasz
Summary: This study proposed a novel way to classify and report surgical outcomes, integrating efficacy and safety at the patient level. By presenting results in four outcome groups ranging from good to poor, the study highlights the importance of balancing efficacy and complications in surgical interventions.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Maria Mavromati, Thomas Mavrakanas, Francois R. Jornayvaz, Karl Schaller, Aikaterini Fitsiori, Maria I. Vargas, Johannes A. Lobrinus, Doron Merkler, Kristof Egervari, Jacques Philippe, Sophie Leboulleux, Shahan Momjian
Summary: This study assessed the impact of transsphenoidal surgery on pituitary function in patients with non-functioning pituitary adenomas (NFPAs) and identified predictive factors. The results showed that the recovery rate of pituitary deficiency after surgery was 46% and the rate of new pituitary deficiency was 10%. Male patients and patients with hyperprolactinemia were more likely to experience pituitary function recovery. Rating: 8/10
Article
Clinical Neurology
Yinxing Huang, Meina Wang, Jianwu Wu, Kunzhe Lin, Shousen Wang, Fangfang Zhang
Summary: The aim of this study was to assess the factors influencing the occurrence of delayed hyponatremia after transsphenoidal surgery (TSS) in patients with a non-functional pituitary adenoma (NFPA). The results showed that delayed postoperative hyponatremia was independently associated with larger craniocaudal dimension, preoperative hyperprolactinemia, and larger preoperative pituitary stalk deviation angle.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Soudeh Ghafouri-Fard, Arash Safarzadeh, Mehdi Akhavan-Bahabadi, Bashdar Mahmud Hussen, Mohammad Taheri, Nader Akbari Dilmaghani
Summary: This study identified differentially expressed genes (DEGs), including long non-coding RNAs (DElncRNAs) and microRNAs (DEmiRNAs), in non-functioning pituitary adenomas (NFPA) compared to normal samples. The study also assessed the relationship between these genes and important signaling pathways. The findings revealed dysregulated pathways and differential expression of several genes in NFPA.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
James R. Janopaul-Naylor, Manali Rupji, Jim Zhong, Bree R. Eaton, Naba Ali, Adriana G. Ioachimescu, Nelson M. Oyesiku, Hui-Kuo G. Shu
Summary: Modern LINAC RT is safe and effective for hormonal control and LC in patients with PAs. There was an increase in the proportion of patients requiring pituitary hormone replacement after RT.
WORLD NEUROSURGERY
(2022)
Article
Endocrinology & Metabolism
Daniela Esposito, Daniel S. Olsson, Stefan Franzen, Mervete Miftaraj, Jonatan Natman, Soffia Gudbjornsdottir, Gudmundur Johannsson
Summary: This study suggests that the presence of diabetes in patients with acromegaly is associated with increased overall mortality, cardiovascular mortality, and morbidity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Margret J. Einarsdottir, Per Ekman, Mattias Molin, Penelope Trimpou, Daniel S. Olsson, Gudmundur Johannsson, Oskar Ragnarsson
Summary: This study investigated the mortality rates of oral glucocorticoid users in a large population-based cohort. The results showed that oral glucocorticoid users had a higher mortality rate compared to the background population, especially high-dose users who had an increased risk of dying from sepsis and pulmonary embolism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Health Care Sciences & Services
Birgit Heckemann, Tatjana Graf, Eva Jakobsson Ung, Sofie Jakobsson, Oskar Ragnarsson, Daniel S. Olsson, Christina Blomdahl
Summary: Personal documentation is a valuable tool for managing life after pituitary adenoma surgery. It helps patients manage their daily lives and communicate their care needs. The study found that personal documentation is used more extensively during periods of poor health and less during periods of relative well-being.
HEALTH EXPECTATIONS
(2023)
Letter
Endocrinology & Metabolism
Oskar Ragnarsson, Per Dahlqvist, Andreas Muth, Jan Calissendorff, Tommy Olsson
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Daniel S. Olsson, Mikael Svensson, Frida Labori, Anna De Geer, Gudmundur Johannsson
Summary: This study investigated the healthcare costs, survival, and cost-effectiveness of growth hormone (GH) replacement therapy in non-functioning pituitary adenoma (NFPA) patients. The results showed that patients receiving GH treatment had higher healthcare costs and higher survival rates. On the other hand, patients with glucocorticoid replacement therapy and diabetes insipidus had lower survival rates.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Eleftheria Gkaniatsa, Oskar Ragnarsson
Summary: Current clinical guidelines may not be accurate for predicting the laterality of adrenal lesions in young patients with primary aldosteronism (PA) based solely on imaging studies. Initial guidelines were based on one study, which included only 6 patients under the age of 35, and since then four additional studies have been published that show discordance between imaging and adrenal venous sampling (AVS) results in patients under 35. These findings challenge the current guidelines and suggest the need for further evaluation.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2023)
Editorial Material
Medicine, General & Internal
Oskar Ragnarsson, Bo Carlberg, Tommy Olsson
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Margret J. Einarsdottir, Maria Bankvall, Jairo Robledo-Sierra, Per-Olof Rodstrom, Ragnhildur Bergthorsdottir, Penelope Trimpou, Bengt Hasseus, Oskar Ragnarsson
Summary: The study aimed to investigate the prevalence of glucocorticoid-induced adrenal insufficiency in patients with oral lichen planus treated with topical clobetasol propionate. The results showed that approximately 20% of patients receiving intermittent topical glucocorticoid treatment for oral lichen planus had glucocorticoid-induced adrenal insufficiency.
Article
Endocrinology & Metabolism
Nasrin Al-Shamkhi, Katarina Berinder, Henrik Borg, Pia Burman, Per Dahlqvist, Charlotte Hoybye, Daniel S. Olsson, Oskar Ragnarsson, Bertil Ekman, Britt Eden Engstrom
Summary: Objective data on pituitary function before and after transsphenoidal surgery in nonfunctioning pituitary adenomas were inconsistent. This study found that adrenocorticotrophic hormone deficiency increased significantly at 1 year postoperatively, while other axis function changes were not significant. Therefore, continuous individual evaluations are needed during longer follow-up of patients operated for NFPA.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Christos Himonakos, Pia Burman, Henrik Borg, Per Dahlqvist, Britt Eden Engstroem, Bertil Ekman, Louise Emilsson, Daniel S. Olsson, Oskar Ragnarsson, Jeanette Wahlberg, Anna-Karin Akerman, Charlotte Hoybye, Katarina Berinder
Summary: This study describes the clinical presentation and treatment outcomes in a nationwide cohort of patients with giant prolactinomas. The results show that dopamine agonists effectively reduced prolactin levels and tumor size, but some patients required additional treatments. The response to dopamine agonists after 1 year can help identify patients who may need more careful monitoring and additional treatment in some cases.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Ragnhildur Bergthorsdottir, Daniela Esposito, Daniel S. Olsson, Oskar Ragnarsson, Per Dahlqvist, Sophie Bensing, Jonatan Natman, Gudmundur Johannsson, Fredrik Nyberg
Summary: Patients with adrenal insufficiency have a similar incidence of COVID-19 infection as the general population, but they have a higher risk of hospitalization, intensive care admission, and death. After adjusting for socioeconomic factors and comorbidities, the hazard ratios for hospitalization, intensive care admission, and death were significantly increased in patients with adrenal insufficiency.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
J. Robert, E. Tsatsaris, K. Berinder, L. Bonelli, P. Burman, P. Dahlqvist, C. Hoybye, D. S. Olsson, O. Ragnarsson, K. Vouzouneraki, A. -k. Akerman, B. Ekman, B. Eden Engstrom
Summary: The aim of this study was to establish a valid national cohort of patients diagnosed with acromegaly by combining data from the National Patient Register and the Swedish Pituitary Register. After applying an algorithm and reviewing medical records, a total of 1034 acromegaly cases were confirmed in Sweden, resulting in a higher estimated incidence rate.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)