Cinnamaldehydes in Cancer Chemotherapy

Cinnamon Extract Inhibits Tau Aggregation Associated with Alzheimer's Disease In Vitro

(2017) Dylan W. Peterson et al.   JOURNAL OF ALZHEIMERS DISEASE

Cinnamic aldehyde suppresses hypoxia-induced angiogenesis via inhibition of hypoxia-inducible factor-1α expression during tumor progression

(2015) Woom-Yee Bae et al.   BIOCHEMICAL PHARMACOLOGY

A Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer

(2015) J.-E. Kim et al.   CANCER RESEARCH

Cinnamaldehyde Derivative (CB-PIC) Sensitizes Chemo-Resistant Cancer Cells to Drug-Induced Apoptosis via Suppression of MDR1 and its Upstream STAT3 and AKT Signalling

(2015) Jianzhong Xi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cinnamon bark oil and its components inhibit biofilm formation and toxin production

(2015) Yong-Guy Kim et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

DJ-1 Protects Breast Cancer Cells Against 2′-Benzoyloxycinnamaldehyde-induced Oxidative Stress Independent of Nrf2

(2015) Ismail Ahmed Ismail et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Polyphenols bearing cinnamaldehyde scaffold showing cell growth inhibitory effects on the cisplatin-resistant A2780/Cis ovarian cancer cells

(2014) Soon Young Shin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

EGR1-dependent PTEN upregulation by 2-benzoyloxycinnamaldehyde attenuates cell invasion and EMT in colon cancer

(2014) Jinkyung Kim et al.   CANCER LETTERS

LRP1-dependent pepsin clearance induced by 2′-hydroxycinnamaldehyde attenuates breast cancer cell invasion

(2014) Hye Suk Kang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Synthesis, Characterization and In Vitro Study of Biocompatible Cinnamaldehyde Functionalized Magnetite Nanoparticles (CPGF Nps) For Hyperthermia and Drug Delivery Applications in Breast Cancer

(2014) Kirtee D. Wani et al.   PLoS One

Immune Suppressive Effect of Cinnamaldehyde Due to Inhibition of Proliferation and Induction of Apoptosis in Immune Cells: Implications in Cancer

(2014) Franziska Roth-Walter et al.   PLoS One

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Research on tumorigenicity of cinnamaldehyde in melanoma cell lines and its mechanism

(2014) Ling Zhou et al.   TUMOR BIOLOGY

Cinnamon extract inhibits degranulation andde novosynthesis of inflammatory mediators in mast cells

(2013) Y. Hagenlocher et al.   ALLERGY

2-Hydroxycinnamaldehyde inhibits the epithelial-mesenchymal transition in breast cancer cells

(2013) Ismail Ahmed Ismail et al.   BREAST CANCER RESEARCH AND TREATMENT

Activation of AMP-Activated Protein Kinaseαand Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells

(2013) Sung-Yun Cho et al.   Evidence-based Complementary and Alternative Medicine

Pharmacokinetic study of cinnamaldehyde in rats by GC–MS after oral and intravenous administration

(2013) Hang Zhao et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

2^|^#8242;-Benzoyloxycinnamaldehyde-Mediated DJ-1 Upregulation Protects MCF-7 Cells from Mitochondrial Damage

(2012) Ismail Ahmed Ismail et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Early growth response protein 1 upregulation and nuclear translocation by 2′-benzoyloxycinnamaldehyde induces prostate cancer cell death

(2012) Hye-Sook Kang et al.   CANCER LETTERS

In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix

(2012) Diana M. Cheng et al.   FOOD CHEMISTRY

Regular ingestion of cinnamomi cortex pulveratus offers gastroprotective activity in mice

(2012) Joan Manjuh Tankam et al.   Journal of Natural Medicines

Antioxidant Activity of Various Parts of Cinnamomum cassia Extracted with Different Extraction Methods

(2012) Cheng-Hong Yang et al.   MOLECULES

Induction of Tumor Cell Death through Targeting Tubulin and Evoking Dysregulation of Cell Cycle Regulatory Proteins by Multifunctional Cinnamaldehydes

(2012) Amrita A. Nagle et al.   PLoS One

Cinnamaldehyde Enhances Nrf2 Nuclear Translocation to Upregulate Phase II Detoxifying Enzyme Expression in HepG2 Cells

(2011) Tzou-Chi Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cinnamaldehyde Prevents Adipocyte Differentiation and Adipogenesis via Regulation of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) and AMP-Activated Protein Kinase (AMPK) Pathways

(2011) Bo Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Orally Administrated Cinnamon Extract Reduces β-Amyloid Oligomerization and Corrects Cognitive Impairment in Alzheimer's Disease Animal Models

(2011) Anat Frydman-Marom et al.   PLoS One

Cytotoxic effect of trans-cinnamaldehyde on human leukemia K562 cells

(2010) Jia-hua Zhang et al.   ACTA PHARMACOLOGICA SINICA

Aqueous Cinnamon Extract (ACE-c) from the bark of Cinnamomum cassiacauses apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential

(2010) Soumya J Koppikar et al.   BMC CANCER

Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1

(2010) Ho-Keun Kwon et al.   BMC CANCER

Differential antiproliferation effect of 2′-benzoyloxycinnamaldehyde in K-ras-transformed cells via downregulation of thiol antioxidants

(2010) Jiyeon Ock et al.   CANCER SCIENCE

2′-Hydroxycinnamaldehyde targets low-density lipoprotein receptor-related protein-1 to inhibit lipopolysaccharide-induced microglial activation

(2010) Heehong Hwang et al.   JOURNAL OF NEUROIMMUNOLOGY

The Cinnamon-Derived Dietary Factor Cinnamic Aldehyde Activates the Nrf2-Dependent Antioxidant Response in Human Epithelial Colon Cells

(2010) Georg Wondrak et al.   MOLECULES

The PTEN Phosphatase Controls Intestinal Epithelial Cell Polarity and Barrier Function: Role in Colorectal Cancer Progression

(2010) Marie-Josée Langlois et al.   PLoS One

Structure–activity analysis of 2′-modified cinnamaldehyde analogues as potential anticancer agents

(2009) Fei Fei Gan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8 + T cells

(2009) Ho-Keun Kwon et al.   CANCER LETTERS

Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9

(2009) H. Song et al.   CANCER RESEARCH

Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling

(2009) J. Lu et al.   CARCINOGENESIS

Antiproliferative Activity ofCinnamomum cassiaConstituents and Effects of Pifithrin-Alpha on Their Apoptotic Signaling Pathways in Hep G2 Cells

(2009) Lean-Teik Ng et al.   Evidence-based Complementary and Alternative Medicine

Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention

(2009) Eng-Hui Chew et al.   FREE RADICAL BIOLOGY AND MEDICINE

Is EGR1 a potential target for prostate cancer therapy?

(2009) Delphine Gitenay et al.   Future Oncology

Inhibitory effects of Geijigajakyak-Tang on trinitrobenzene sulfonic acid-induced colitis

(2009) Ji Yun Lee et al.   JOURNAL OF ETHNOPHARMACOLOGY

2′-Benzoyloxycinnamaldehyde Inhibits Tumor Growth in H-ras12V Transgenic Mice via Downregulation of Metallothionein

(2009) Heun-Sik Lee et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses

(2009) S. Vasseur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma pharmacokinetics and metabolism of the antitumour drug candidate 2′-benzoyloxycinnamaldehyde in rats

(2009) Kiho Lee et al.   XENOBIOTICA

Transport and metabolism of the antitumour drug candidate 2′-benzoyloxycinnamaldehyde in Caco-2 cells

(2009) K. Lee et al.   XENOBIOTICA

Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: is PTEN loss predictor of local recurrence?

(2008) Tamer Colakoglu et al.   AMERICAN JOURNAL OF SURGERY

Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

(2008) D. Morishita et al.   CANCER RESEARCH

CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis

(2008) Krista Ouwehand et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth

(2008) Christopher M. Cabello et al.   FREE RADICAL BIOLOGY AND MEDICINE

A polyphenol mixture from cinnamon targets p38 MAP kinase-regulated signaling pathways to produce G2/M arrest

(2008) Norberta W. Schoene et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

LRP-1 Silencing Prevents Malignant Cell Invasion despite Increased Pericellular Proteolytic Activities

(2008) S. Dedieu et al.   MOLECULAR AND CELLULAR BIOLOGY

Flavonoids and cinnamic acid derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 1

(2008) Petra Brožič et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis

(2008) P. G. Rychahou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization

(2007) Hyung S. Youn et al.   BIOCHEMICAL PHARMACOLOGY