Article
Plant Sciences
Qi-Jing Fan, Gang-Zhong Zhou, Chu-Chu Xi, Bo Niu, Yan-Gang Cao, Fan Zhang, C. Benjamin Naman, Chun-Lei Zhang, Zheng-Yu Cao
Summary: Thirteen new benzamide alkaloids were isolated from Delphinium anthriscifolium. Compound 1 possesses a previously undescribed carbon framework. Compound 2 is an artifact formed during the extraction process. Compound 7 is glycosylated while compound 13 contains a chlorine substituent. Compounds 6, 8, and 10-12 showed significant inhibition of LPS-induced NO production in cells.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Huanhuan Ma, Yunxia Ma, Zeren Dawa, Yufeng Yao, Meiqi Wang, Kaihui Zhang, Chenchen Zhu, Fangle Liu, Chaozhan Lin
Summary: This research identified four novel diterpenoid alkaloids from Delphinium brunonianum with activity reducing hepatocytes lipid accumulation. One of the alkaloids showed the strongest inhibitory effect. The study provides experimental evidence for the chemical composition of D. brunonianum and its potential in treating diseases related to lipid accumulation.
Article
Biochemistry & Molecular Biology
Jin-Bu Xu, Yu-Zhu Li, Shuai Huang, Lin Chen, Yan-Yan Luo, Feng Gao, Xian-Li Zhou
Summary: Seven new diterpenoid alkaloids were isolated from Delphinium grandiflorum, along with eight reaction products and thirteen known compounds. Grandiflonines A and B have a unique C-20 diterpenoid alkaloid skeleton, with the configuration of C-18 inverted. The analgesic and anti-inflammatory activities of these compounds were evaluated, with deoxylappaconitine showing superior analgesic activity compared to lappaconitine.
Article
Plant Sciences
Yang-Li Pu, Ling-Feng Tian, Lin Chen, Meng-Yi Deng, Jiang Xie, Shuai Huang, Xian-Li Zhou
Summary: Three new hetisine type C-20-diterpenoid alkaloids, trichophorines A-C (1-3), were isolated from Delphinium trichophorum, along with nine known alkaloids (4-12). Their structures were determined using spectroscopic methods. None of the compounds showed significant inhibitory activity against LPS-induced NO production in RAW 264.7 macrophage cells.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Ashraf M. A. Qasem, Ziyu Zeng, Michael G. Rowan, Ian S. Blagbrough
Summary: Norditerpenoid alkaloids (NDA) are complex natural products with important pharmacological activities. Research has shown that understanding the metabolism of NDA is crucial for their development as drugs.
NATURAL PRODUCT REPORTS
(2022)
Article
Plant Sciences
Tianpeng Yin, Yuanfeng Yan, Xing Li, Guowei Gong, Wenjun Wang
Summary: Three new diterpenoid alkaloids were isolated from the whole plants of Delphinium tatsienense Franch., a folk medicine in China for wind-toxin syndrome treatment. The structures of these alkaloids were determined through extensive spectroscopic analyses. Their potential anti-inflammatory effects were evaluated against NO production in LPS-stimulated RAW 264.7 macrophages.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Di Jing, Yunhong Zhang, Chang Gong, Kaicheng Du, Yumeng Wang, Lantao Lai, Dali Meng
Summary: This study isolated seven undescribed compounds with medicinal and anti-inflammatory activities from Delphinium kamaonense. In vitro assays showed significant inhibitory effects on nitric oxide, indicating potential anti-inflammatory properties. The mechanism of action may be related to the MAPK signaling pathway. Molecular docking results revealed two promising pharmacophores for the lycaconitine-type C19-diterpenoid alkaloids, namely the uncommon amides and methylenedioxy groups.
Article
Biochemistry & Molecular Biology
Mohammad Alhilal, Yaser A. M. Sulaiman, Suzan Alhilal, Sobhi M. Gomha, Salama A. Ouf
Summary: This study isolated new alkaloids from Delphinium peregrinum and evaluated their antifungal activity against different dermatophyte fungal isolates. Peregrine (2) was found to be the most effective alkaloid, but the application of a mixture of alkaloids showed significant synergistic activity.
Article
Biochemistry & Molecular Biology
Nurfida Ablajan, Wen-Juan Xue, Jiang-Yu Zhao, Abdubakiev Sardorbek, Nurmirza Boymirzayevich Begmatov, Shamansur Sagdullaev, Bo Zhao, Haji Akber Aisa
Summary: A pair of new regioisomeric C-19-diterpenoid alkaloids, Shawurenine C (1a) and Shawurenine D (1b), along with five known C-19-diterpenoid alkaloids (2-6), were isolated from the aerial part of Delphinium shawurense W. T. Wang. The chemical structures of the new compounds were determined through spectroscopic analyses, including HR-ESI-MS and 1D, 2D NMR spectroscopic data. Additionally, the anti-inflammatory and cytotoxic activities of these diterpenoid alkaloids were evaluated.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Zhuorui Song, Chengfeng Gao, Qinghua Jiang, Jinyu Xu, Liangliang Xiong, Kexin Liu, Dejuan Sun, Hua Li, Lixia Chen
Summary: Six new diterpenoid alkaloids were isolated from Delphinium forrestii var. vride, with forrestline F showing the strongest anti-inflammatory activity. It acted through multiple mechanisms by suppressing inflammatory cytokines, modulating NF-kappa B/MAPK and Nrf2/HO-1 signaling pathways.
Article
Medicine, Research & Experimental
Yufeng Yao, Yuanyuan Chen, Dawa Zeren, Yunxia Ma, Yuanyuan Xie, Qian Wang, Huanhuan Ma, Meiqi Wang, Fangle Liu, Chenchen Zhu, Chaozhan Lin
Summary: This study investigated the anti-fibrotic effects of five major components from Delphinium trichophorum on fibroblasts for the first time. The results showed that all five compounds could effectively reduce abnormal proliferation of fibroblasts and decrease collagen production. Among them, DTF1 and DTF2 demonstrated superior effectiveness. Further experiments revealed that DTF1 and DTF2 exerted their effects by inhibiting the activation of the TGF-β1/Smad signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Applied
Xinyu Li, Meizhen Ye, Feng Gao, Xianli Zhou, Lin Chen, Shuai Huang
Summary: A new C-19-diterpenoid alkaloid named gyalanutine A and fourteen known compounds were isolated from the plant of Delphinium gyalanum. The structure of gyalanutine A was determined to have an unusual lycoctonine-type skeleton. The compounds were tested for acetylcholinesterase inhibitory and anti-inflammatory activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Chang Gong, Guangxin Zhou, Di Jing, Huijie Song, Jixuan Xu, Dali Meng
Summary: In this study, a new amide and two phenylpropanoid derivatives, along with three new natural products, were isolated from Delphinium kamaonense Hunth. Their structures and absolute configurations were determined by various analytical techniques. Compound 1 showed moderate cytotoxicity against Hep-3B cancer cells and excellent antioxidant activity.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Organic
Mei-Zhen Ye, Xin-Yu Li, Jiang Xie, Lin Chen, Feng Gao, Xian-Li Zhou, Shuai Huang
Summary: Two new C-20-diterpenoid alkaloids were isolated from the whole plant of Delphinium gyalanum. One of the compounds exhibited appreciable cardiotonic activity, possibly related to the beta receptor.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Quanzheng Zhang, Zhao Yang, Qi Wang, Shuangwei Liu, Tao Zhou, Yankun Zhao, Min Zhang
Summary: In this study, the first asymmetric total synthesis of two hetidine-type C-20-diterpenoid alkaloids was reported. A highly regio- and diastereoselective 1,3-dipolar cycloaddition of an azomethine ylide was utilized to yield a chiral tetracyclic intermediate, serving as the basis for the asymmetric assembly of the hexacyclic hetidine skeleton. Another key transformation involved the dearomative cyclopropanation of the benzene ring and subsequent S(N)2-like ring opening to establish the B ring and install the equatorial C7-OH group.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Applied
Lin Chen, Lianhai Shan, Wenliang Xu, Jifa Zhang, Shuai Huang, Xianli Zhou
NATURAL PRODUCT RESEARCH
(2017)
Article
Chemistry, Organic
Shuai Huang, Jifa Zhang, Lianhai Shan, Yi Zhang, Xianli Zhou
Article
Chemistry, Medicinal
Shuai Huang, Run Wu, Feng Gao, Chunying Li, Xianli Zhou
JOURNAL OF NATURAL MEDICINES
(2018)
Article
Chemistry, Applied
Haiyue Jiang, Shuai Huang, Feng Gao, Yongqi Zhen, Chunying Li, Xianli Zhou
NATURAL PRODUCT RESEARCH
(2019)
Article
Nanoscience & Nanotechnology
Jun-Feng Feng, Jiao-Long Chen, Kun Guo, Jun-Bo Hou, Xian-Li Zhou, Shuai Huang, Bang-Jing Li, Sheng Zhang
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Biochemistry & Molecular Biology
Lin Chen, Shuai Huang, Chun Ying Li, Feng Gao, Xian Li Zhou
Article
Chemistry, Medicinal
Shuangmei Zhao, Yongqi Zhen, Leilei Fu, Feng Gao, Xianli Zhou, Shuai Huang, Lan Zhang
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Biochemistry & Molecular Biology
Shuai Huang, Ji-Fa Zhang, Lin Chen, Feng Gao, Xian-Li Zhou
Article
Chemistry, Applied
Xinyu Li, Meizhen Ye, Feng Gao, Xianli Zhou, Lin Chen, Shuai Huang
Summary: A new C-19-diterpenoid alkaloid named gyalanutine A and fourteen known compounds were isolated from the plant of Delphinium gyalanum. The structure of gyalanutine A was determined to have an unusual lycoctonine-type skeleton. The compounds were tested for acetylcholinesterase inhibitory and anti-inflammatory activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Yufeng Du, Linyu Huang, Neng Wang, Xiaohuan Li, Xian-Li Zhou, Lan Zhang, Shuai Huang, Patrick J. Walsh, Feng Gao
Summary: A Rh-2(OAc)(4)/IMes . HCl system is reported in this study, which enables the chemoselective installation of aryl groups at the 2-position of furo[2,3-b]pyridine with yields ranging from 53% to 94%. The modified furoquinoline alkaloid dictamnine shows improved cardiac effects compared to the natural compound, possibly through interactions with epinephrine alpha receptors, M-receptors, and calcium channel receptors.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Organic
Mei-Zhen Ye, Xin-Yu Li, Jiang Xie, Lin Chen, Feng Gao, Xian-Li Zhou, Shuai Huang
Summary: Two new C-20-diterpenoid alkaloids were isolated from the whole plant of Delphinium gyalanum. One of the compounds exhibited appreciable cardiotonic activity, possibly related to the beta receptor.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Organic
Shuai Huang, Yuming Feng, Jiali Ren, Chuanlun Yang, Lin Chen, Xianli Zhou
Summary: In this study, four new diterpenoid alkaloids were isolated from the roots of Aconitum rockii, including three C-19-diterpenoid alkaloids and one C-20-diterpenoid alkaloid. Compound 13 showed highly potent antifeedant activity.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Jue Wang, Jin-bu Xu, Hong-bo Yang, Feng Gao, Xian-li Zhou, Lin Chen, Shuai Huang
Summary: Two new diterpenoid alkaloids and eight known ones were isolated from the root of Aconitum leucostomum. Compound 2 showed antifeedant activity with an effective concentration for 50% feeding reduction (EC50) at 1.54 mg/cm(2).
Article
Integrative & Complementary Medicine
Huang Shuai, Zhao Shuang-Mei, Shan Lian-Hai, Zhou Xian-Li
CHINESE JOURNAL OF NATURAL MEDICINES
(2020)
Article
Biochemistry & Molecular Biology
Ji-Fa Zhang, Lian-Hai Shan, Feng Gao, Shuai Huang, Xian-Li Zhou
CHEMISTRY & BIODIVERSITY
(2017)
Article
Plant Sciences
Yi Zhu, Junlin Wang, Lu Tang, Yuxin Shang, Weiyi Zhao, Wei Zhang, Ping Hai, Yongbiao Zheng, Wenbo Li, Yanfang Su
Summary: One new iridoid glucoside and two new lignan glycosides, along with three known compounds, were isolated from the whole plants of Lancea tibetica. The structures were determined by spectroscopic methods and X-ray crystallographic analysis. One of the new iridoid glucosides and the known compounds exhibited moderate antioxidant activity.
PHYTOCHEMISTRY LETTERS
(2024)
Article
Plant Sciences
Yi Deng, Minghua Chen, Junming Yi, Yuguo Zheng
Summary: This study successfully designed and synthesized a series of quinazolinone derivatives containing purine molecules, and found that some compounds exhibited strong antiviral activity against tobacco mosaic virus. The findings have important implications for further development of antiviral drugs.
PHYTOCHEMISTRY LETTERS
(2024)
