Journal
PHYTOCHEMISTRY LETTERS
Volume 18, Issue -, Pages 14-18Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2016.08.013
Keywords
Meroterpenoids; Petchiether A; Petchiether B; Absolute configuration
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Funding
- National Natural Science Foundation of China [21272241]
- NSFC-Joint Foundation of Yunnan Province [U1202222]
- State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany [P2016-ZZ02]
- Center of Cooperative Innovation for South China Medicine of Yunnan Province
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Petchiethers A (1) and B (2), two novel meroterpenoids respectively with a 14- or 15-membered ring were isolated from the fruiting bodies of Ganoderma petchii. Their structures were identified by spectroscopic data. The absolute configurations of compounds 1 and 2 were assigned by computational methods. In particular, the stereochemistry of 1 was further confirmed by the Mosher's method. The inhibitory effects of compounds 1 and 2 on fibronectin secretion were evaluated by using the ELISA technique in TGF-beta 1-induced rat kidney tubular epithelial cells. The results show that these substances could inhibit fibronectin production in a dose-dependent manner, indicating their potential on kidney protection. (C) 2016 Published by Elsevier Ltd on behalf of Phytochemical Society of Europe.
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