Withaphysalin-type withanolides from Physalis minima

Nine new withaphysalin-type withanolides (1-9), named physaminimins (G-O) were isolated from the whole plants of Physalis minima Linn. The structures of these compounds were elucidated based on spectroscopic methods (1D NMR, HSQC, HMBC, ROESY) and HRESIMS. Physaminimins G, H, and K showed inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in a macrophage (RAW264.7) cells with IC50 values of 17.41 +/- 1.04, 36.33 +/- 1.95 and 21.48 +/- 1.67 mu M, respectively. a 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.