Journal
PHYTOCHEMISTRY
Volume 127, Issue -, Pages 50-62Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2016.03.011
Keywords
Magnolia officinalis; Magnoliaceae; Phenylethanoid glycoside; Phenolic glycoside; alpha-Glucosidase inhibitory effect; Cytotoxicity
Categories
Funding
- 863 Project [2014AA022201]
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An investigation of the hydrophilic constituents of the stem bark of Magnolia officinalis was performed and which led to isolation and identification of twenty-one previously unreported glycosides. These included eleven phenylethanoid glycosides, magnolosides F-P, and ten phenolic glycosides, magnolosides Q-Z, along with eight known compounds. Their structures were elucidated on the basis of extensive spectroscopic analyses and chemical hydrolysis methods, as well as by comparison with literature data. Most of the phenylethanoid glycosides contained an allopyranose moiety, which is rare in the plant kingdom. Magnolosides I and K as well as 2-(3,4-dihydroxyphenyl) ethanol 1-O-[4-O-caffeoyl-2-O-alpha-L-rhamnopyranosyl-3-O-alpha-L-rhamnopyranosyl-6-O-beta-D-glucopyranosyl]-beta-D-glucopyranoside showed more potent alpha-glucosidase inhibitory effects (IC50 values of 0.13, 0.27, and 0.29 mM, respectively) than the positive control, acarbose (IC50 value of 1.09 mM) in vitro. Magnolosides H, E and D also showed moderate cytotoxicity against MGC-803 and HepG2 cells with IC50 values of 13.59-17.16 mu M and 29.53-32.46 mu M, respectively. (C) 2016 Elsevier Ltd. All rights reserved.
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