Article
Biology
Alessandra Caruso, Alessandra Gaetano, Sergio Scaccianoce
Summary: CRH plays a role in regulating multiple biological systems, and is also associated with reproduction, neuropsychiatric, gastrointestinal, immune disorders, and tumor development. Further research on the physiological functions of CRH will help determine its role in human diseases and may serve as novel therapeutic targets.
Article
Neurosciences
Angelica Roque, Kinberli Marcela Valles Mendez, Roberto Ruiz, Edel Pineda, Naima Lajud
Summary: Maternal separation during early life has both short-term and long-term effects on neuropeptide expression and HPA axis activity in the hippocampus and hypothalamus of rats, resulting in cognitive impairments and behavioral abnormalities in adulthood.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Krisztina Csabafi, Katalin Eszter Ibos, Eva Bodnar, Kata Filkor, Julia Szakacs, Zsolt Bagosi
Summary: Intracerebroventricular administration of KP-13 induces anxiety-like behavior and activates the HPA axis in rats. The study found that KP-13 alters the AVP and CRF signaling, which may be responsible for its effect on the HPA axis and anxiety-like behavior.
Article
Environmental Sciences
Xue Liu, Jiaqian Feng, Zhijing Jiang, Guangbo Zhang, Xiuwen Xu, Jixiu Wang, Jingwen Yang, Tianming Wang
Summary: In the neuroendocrine system, corticotropin-releasing hormone (CRH) activates CRHRs and plays a vital role in the HPA/HPI axis. Two CRHR1 subtypes, LcCRHR1-1 and LcCRHR1-2, were identified in Larimichthys crocea genome and were found to be highly homologous to known teleost CRHRs. These receptors were found to be localized in the cell membrane and respond to LcCRH by increasing cAMP, Ca2+ and mitogen-activated protein kinase phosphorylation. LcCRHR1s were expressed in various tissues, with high expression in the brain and ovaries, and shown to be specifically localized in ovarian follicle cells. This study suggests that the CRH/CRHR1 system may be involved in the neuroendocrine regulation of reproduction in L. crocea.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Willian O. dos Santos, Daniela O. Gusmao, Frederick Wasinski, Edward O. List, John J. Kopchick, Jose Donato
Summary: The ablation of GHR in CRH cells does not lead to major alterations in metabolism, the hypothalamic-pituitary-adrenal axis, acute stress response, or anxiety in mice. While reduced energy expenditure was observed in female mice, the overall physiological importance of GH action on CRH neurons remains uncertain and warrants further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Erin Faught, Mathilakath M. Vijayan
Summary: The study demonstrates that the CRH/CRHR1 system mediates stress-induced hyperactivity, while the temporal activation of cortisol production and associated GR/MR signaling are crucial for prolonging stressor-induced hyperactivity.
NEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Susana Silberstein, Ana Clara Liberman, Paula Ayelen dos Santos Claro, Maria Belen Ugo, Jan M. Deussing, Eduardo Arzt
Summary: Depression and other psychiatric stress-related disorders are major causes of disability worldwide. Inflammatory processes have been identified as key pathophysiological mechanisms in psychiatric conditions, with the CRH system and P2X7 receptor playing essential roles in controlling these pathways.
NEUROIMMUNOMODULATION
(2021)
Article
Immunology
Joao Paulo Bras, Isabelle Guillot de Suduiraut, Olivia Zanoletti, Silvia Monari, Mandy Meijer, Jocelyn Grosse, Mario Adolfo Barbosa, Susana Gomes Santos, Carmen Sandi, Maria Ines Almeida
Summary: This study suggests that male rats with high-CORT stress responsiveness exhibit increased anhedonia and passive coping responses in adulthood following peripubertal stress exposure. Additionally, exposure to peripubertal stress leads to increased hippocampal TNF-alpha expression, which correlates with passive coping responses. Furthermore, peripubertal stress has long-term effects on hippocampal microglia, particularly in high-CORT stress-responsive rats.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Biochemistry & Molecular Biology
Kazunori Kageyama, Yasumasa Iwasaki, Makoto Daimon
Summary: This review focuses on the molecular mechanisms of CRF regulation in the hypothalamus during stress and stress resilience, highlighting the central role of CRF in regulating the stress response. The involvement of ACTH, glucocorticoids, various regulatory factors, and different CRF receptors in stress resilience are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Qiang Wu, Yan Feng, Ling Liu, Yang Liu, Xin Liu, Liqiao Zhang, Yanan Li, Liqun Wang
Summary: CRF plays a proinflammatory role in ischemic stroke by activating and transforming microglial cells through the TLR4/NF-kappa B signaling pathway, leading to aggravated neuronal injuries.
Article
Cardiac & Cardiovascular Systems
Zhao-Fu Sheng, Hua Zhang, Jeffery G. Phaup, PeiRu Zheng, XunLei Kang, Zhenguo Liu, Hui-Ming Chang, Edward T. H. Yeh, Alan Kim Johnson, Hui-Lin Pan, De-Pei Li
Summary: Chronic stress is a known risk factor for the development of hypertension. In this study, it was found that the corticotropin-releasing hormone (CRH) neurons in the central nucleus of the amygdala (CeA) are involved in the autonomic responses to chronic stress. Suppressing CeA-CRH neurons can alleviate chronic stress-induced hypertension and decrease elevated sympathetic outflow. Additionally, chronic stress leads to decreased levels of Kv7.2 and Kv7.3 channels in the CeA, which contribute to the hyperactivity of CeA-CRH neurons.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mahendra Wagle, Mahdi Zarei, Matthew Lovett-Barron, Kristina Tyler Poston, Jin Xu, Vince Ramey, Katherine S. Pollard, David A. Prober, Jay Schulkin, Karl Deisseroth, Su Guo
Summary: This study investigates the role of hypothalamic corticotropin releasing factor neurons in regulating the perception and emotional valence of light. The findings suggest that these neurons play a significant role in light perception and mood disorders, and light therapy may alleviate these disorders by reducing the overall activity of these neurons.
MOLECULAR PSYCHIATRY
(2022)
Review
Neurosciences
Antonio Armario, Xavier Belda, Humberto Gagliano, Silvia Fuentes, Patricia Molina, Sara Serrano, Roser Nadal
Summary: The hormones of the HPA axis, especially glucocorticoids, play a crucial role in the behavioral and physiological effects of stress. Studies have shown complex and poorly understood relationships between HPA function and behavioral characteristics. This review discusses methodological considerations, explores differences in HPA function between rat strains, and examines the relationship between HPA differences and relevant behaviors.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Clinical Neurology
Alexandros N. Vgontzas, Julio Fernandez-Mendoza, Kristina Puzino Lenker, Maria Basta, Edward O. Bixler, George P. Chrousos
Summary: Insomnia, especially when associated with objective sleep disturbance, was found to be related to activation of the hypothalamic-pituitary-adrenal axis. Men with insomnia demonstrated shorter total sleep time and lower sleep efficiency on polysomnography, as well as lower levels of adrenocorticotropic hormone and cortisol after exposure to stress, suggesting a disrupted hypothalamic-pituitary-adrenal axis function in this population.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Multidisciplinary Sciences
Romina Tome, Marcos A. Rangel, Christina M. Gibson-Davis, Laura Bellows
Summary: The study found that increased ICE activities in North Carolina negatively affected newborn health and prenatal care utilization, resulting in decreased birth weight and worsening prenatal care services. This could have significant socio-economic impacts on US-born citizens.
Review
Endocrinology & Metabolism
Annette D. de Kloet, James P. Herman
FRONTIERS IN NEUROENDOCRINOLOGY
(2018)
Article
Geriatrics & Gerontology
Joseph A. McQuail, Eric G. Krause, Barry Setlow, Deborah A. Scheuer, Jennifer L. Bizon
NEUROBIOLOGY OF AGING
(2018)
Article
Multidisciplinary Sciences
Andrew J. Shepherd, Aaron D. Mickle, Judith P. Golden, Madison R. Mack, Carmen M. Halabi, Annette D. de Kloet, Vijay K. Samineni, Brian S. Kim, Eric G. Krause, Robert W. Gereau, Durga P. Mohapatra
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Review
Endocrinology & Metabolism
Edo R. de Kloet, Sybren F. de Kloet, Carien S. de Kloet, Annette D. de Kloet
JOURNAL OF NEUROENDOCRINOLOGY
(2019)
Article
Neurosciences
Yalun Tan, Sarthak M. Singhal, Scott W. Harden, Karlena M. Cahill, Dan-Tam M. Nguyen, Luis M. Colon-Perez, Todd J. Sahagian, Jeffrey S. Thinschmidt, Annette D. de Kloet, Marcelo Febo, Charles J. Frazier, Eric G. Krause
JOURNAL OF NEUROSCIENCE
(2019)
Article
Endocrinology & Metabolism
Irina Kusmartseva, Maria Beery, Helmut Hiller, Myriam Padilla, Stephen Selman, Amanda Posgai, Harry S. Nick, Martha Campbell-Thompson, Desmond A. Schatz, Michael J. Haller, Clive H. Wasserfall, Mark A. Atkinson
Article
Endocrinology & Metabolism
Dipanwita Pati, Scott W. Harden, Wanhui Sheng, Kyle B. Kelly, Annette D. de Kloet, Eric G. Krause, Charles J. Frazier
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Article
Multidisciplinary Sciences
Mirza Muhammad Fahd Qadir, Silvia Alvarez-Cubela, Jonathan Weitz, Julia K. Panzer, Dagmar Klein, Yaisa Moreno-Hernandez, Sirlene Cechin, Alejandro Tamayo, Joana Almaca, Helmut Hiller, Maria Beery, Irina Kusmartseva, Mark Atkinson, Stephan Speier, Camillo Ricordi, Alberto Pugliese, Alejandro Caicedo, Christopher A. Fraker, Ricardo Luis Pastori, Juan Dominguez-Bendala
NATURE COMMUNICATIONS
(2020)
Article
Medicine, Research & Experimental
Julia K. Panzer, Helmut Hiller, Christian M. Cohrs, Joana Almaca, Stephen J. Enos, Maria Beery, Sirlene Cechin, Denise M. Drotar, John R. Weitz, Jorge Santini, Mollie K. Huber, Mirza Muhammad Fahd Qadir, Ricardo L. Pastori, Juan Dominguez-Bendala, Edward A. Phelps, Mark A. Atkinson, Alberto Pugliese, Alejandro Caicedo, Irina Kusmartseva, Stephan Speier
Article
Neurosciences
Khalid Elsaafien, Matthew K. Kirchner, Mazher Mohammed, Sophia A. Eikenberry, Chloe West, Karen A. Scott, Annette D. de Kloet, Javier E. Stern, Eric G. Krause
Summary: The PVNAgtr1a neurons play a key role in coordinating neuroendocrine axes and sympathetic nervous system responses to stress. These neurons synthesize CRH and activate neighboring neurons expressing CRHR1, ultimately regulating blood pressure in male mice through the hypothalamic-pituitary-adrenal axis and sympathetically mediated vasoconstriction.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Mollie K. Huber, Denise M. Drotar, Helmut Hiller, Maria L. Beery, Paul Joseph, Irina Kusmartseva, Stephan Speier, Mark A. Atkinson, Clayton E. Mathews, Edward A. Phelps
Summary: Live pancreatic tissue slices offer a novel approach to studying islet physiology and function while preserving tissue viability, function, and underlying pathologies. This method allows for the maintenance of complex structures and cellular interactions for in-depth research on the pancreas.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Endocrinology & Metabolism
Helmut Hiller, Dawn E. Beachy, Joseph J. Lebowitz, Stefanie Engler, Justin R. Mason, Douglas R. Miller, Irina Kusmarteva, Laura M. Jacobsen, Amanda L. Posgai, Habibeh Khoshbouei, Richard A. Oram, Desmond A. Schatz, Andrew T. Hattersley, Bernd Bodenmiller, Mark A. Atkinson, Harry S. Nick, Clive H. Wasserfall
Summary: This study found dysregulated expression of monogenic diabetes genes in the pancreas of individuals with T1D and at risk for T1D, with some genes related to cellular stress responses. Three arms of the ISR were significantly repressed in the pancreas of autoantibody+ individuals.
Article
Endocrinology & Metabolism
Helmut Hiller, Changjun Yang, Dawn E. Beachy, Irina Kusmartseva, Eduardo Candelario-Jalil, Amanda L. Posgai, Harry S. Nick, Desmond Schatz, Mark A. Atkinson, Clive H. Wasserfall
Summary: This study evaluated the localization and trafficking of PrPC in human pancreases and identified its interaction with proteins involved in cyto-protection, signaling, differentiation, and morphogenesis. The expression of both PRNP and STIP1 genes, encoding PrPC and its interacting partner STI1, were found to be significantly altered in type 1 diabetic and autoantibody-positive pancreases.