Synthesis and properties of hybrid hydroxyapatite-ferrite (Fe3O4) particles for hyperthermia applications

Hybrid ceramics consisting of hydroxyapatite Ca-10(PO4)(6)(OH)(2) and ferrite Fe3O4 were synthesized using a two-stage procedure. The first stage included the synthesis of Fe3O4 ferrite particles by co-precipitation and the synthesis of hydroxyapatite. In the second stage, the magnetic hybrid hydroxyapatite-ferrite bioceramics were synthesized by a thorough mixing of the obtained powders of carbonated hydroxyapatite and Fe3O4 ferrite taken in a certain proportion, pressing into tablets, and annealing in a carbon dioxide atmosphere for 30 min at a temperature of 1200A degrees C. The properties of the components and hybrid particles were investigated using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and Mossbauer spectroscopy. The saturation magnetization of the hybrid ceramic composite containing 20 wt % Fe3O4 was found to be 12 emu/g. The hybrid hydroxyapatite (Ca-10(PO4)(6)(OH)(2))-ferrite Fe3O4 ceramics, which are promising for the use in magnetotransport and hyperthermia treatment, were synthesized and investigated for the first time.