Journal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Volume 18, Issue 40, Pages 28101-28109Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cp02529c
Keywords
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Funding
- EPSRC
- Ondine Biopharma
- Engineering and Physical Sciences Research Council [EP/K03930X/1, 955465] Funding Source: researchfish
- Medical Research Council [G0902208] Funding Source: researchfish
- EPSRC [EP/K03930X/1] Funding Source: UKRI
- MRC [G0902208] Funding Source: UKRI
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Surfaces with built-in antimicrobial activity have the potential to reduce hospital-acquired infections. One promising strategy is to create functionalised surfaces which, following illumination with visible light, are able to generate singlet oxygen under aerobic conditions. In contrast to antibiotics, the mechanism of bacterial kill by species derived from reactions with singlet oxygen is completely unselective, therefore offering little room for evolutionary adaptation. Here we consider five commercially available organic photosensitiser dyes encapsulated in silicone polymer that show varied antimicrobial activity. We correlate density functional theory calculations with UV-Vis spectroscopy, electron paramagnetic resonance spectroscopy and singlet oxygen production measurements in order to define and test the elements required for efficacious antimicrobial activity. Our approach forms the basis for the rational in silico design and spectroscopic screening of simple and efficient self-sterilising surfaces made from cheap, low toxicity photosensitiser dyes encapsulated in silicone.
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