Glycerol inhibits the primary pathways and transforms the secondary pathway of insulin aggregation

Molecular mechanisms of protein aggregation from global fitting of kinetic models

(2016) Georg Meisl et al.   Nature Protocols

Curcumin binds to the pre-fibrillar aggregates of Cu/Zn superoxide dismutase (SOD1) and alters its amyloidogenic pathway resulting in reduced cytotoxicity

(2015) Nidhi K. Bhatia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Inhibition of insulin fibrillation by osmolytes: Mechanistic Insights

(2015) Sinjan Choudhary et al.   Scientific Reports

Amyloid Fibril Formation by the Chain B Subunit of Monellin Occurs by a Nucleation-Dependent Polymerization Mechanism

(2014) A. T. Sabareesan et al.   BIOCHEMISTRY

Switch in the Aggregation Pathway of Bovine Serum Albumin Mediated by Electrostatic Interactions

(2014) Shivnetra Saha et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical kinetics for drug discovery to combat protein aggregation diseases

(2014) Paolo Arosio et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mechanistic Studies Unravel the Complexity Inherent in Tau Aggregation Leading to Alzheimer’s Disease and the Tauopathies

(2013) Gayathri Ramachandran et al.   BIOCHEMISTRY

A Mechanistic Model for Amorphous Protein Aggregation of Immunoglobulin-like Domains

(2013) Madeleine B. Borgia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2

(2013) L.-Q. Xu et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curcumin Modulates α-Synuclein Aggregation and Toxicity

(2012) Pradeep K. Singh et al.   ACS Chemical Neuroscience

Role of Elongation and Secondary Pathways in S6 Amyloid Fibril Growth

(2012) Nikolai Lorenzen et al.   BIOPHYSICAL JOURNAL

Unraveling amyloid toxicity pathway in NIH3T3 cells by a combined proteomic and1H-NMR metabonomic approach

(2012) Annalisa Vilasi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation

(2012) Samuel I.A. Cohen et al.   JOURNAL OF MOLECULAR BIOLOGY

Evidence for the Existence of a Secondary Pathway for Fibril Growth during the Aggregation of Tau

(2012) Gayathri Ramachandran et al.   JOURNAL OF MOLECULAR BIOLOGY

Use of quencher to decode three-state nature of unfolding of proteins from fluorescence intensity–temperature profiles

(2012) Komal Saini et al.   THERMOCHIMICA ACTA

Interactions of formulation excipients with proteins in solution and in the dried state

(2011) Satoshi Ohtake et al.   ADVANCED DRUG DELIVERY REVIEWS

Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations

(2011) Samuel I. A. Cohen et al.   JOURNAL OF CHEMICAL PHYSICS

Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

(2011) Samuel I. A. Cohen et al.   JOURNAL OF CHEMICAL PHYSICS

The Mechanism of Enhanced Insulin Amyloid Fibril Formation by NaCl Is Better Explained by a Conformational Change Model

(2011) Mahvish Muzaffar et al.   PLoS One

Detection and reduction of microaggregates in insulin preparations

(2010) Caryn L. Heldt et al.   BIOTECHNOLOGY AND BIOENGINEERING

Amyloid oligomers: formation and toxicity of Aβ oligomers

(2010) Masafumi Sakono et al.   FEBS Journal

Effect of the sugar and polyol additives on the aggregation kinetics of BSA in the presence of N-cetyl-N,N,N-trimethyl ammonium bromide

(2010) Anurag Sharma et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils

(2010) Mahiuddin Ahmed et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanisms of Protein Stabilization and Prevention of Protein Aggregation by Glycerol

(2009) Vincent Vagenende et al.   BIOCHEMISTRY

Molecular basis for insulin fibril assembly

(2009) Magdalena I. Ivanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Protein aggregation kinetics, mechanism, and curve-fitting: A review of the literature

(2008) Aimee M. Morris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Formation of highly toxic soluble amyloid beta oligomers by the molecular chaperone prefoldin

(2008) Masafumi Sakono et al.   FEBS Journal

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

(2008) Wei-Feng Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Protein Fibril Formation: Nucleated Polymerization with Competing Off-Pathway Aggregation

(2007) Evan T. Powers et al.   BIOPHYSICAL JOURNAL

A kinetic study of β-lactoglobulin amyloid fibril formation promoted by urea

(2002) Daizo Hamada et al.   PROTEIN SCIENCE