Article
Environmental Sciences
Jongeun Rhee, Erikka Loftfield, Demetrius Albanes, Tracy M. Layne, Rachael Stolzenberg-Solomon, Linda M. Liao, Mary C. Playdon, Sonja I. Berndt, Joshua N. Sampson, Neal D. Freedman, Steven C. Moore, Mark P. Purdue
Summary: This study aimed to investigate the biological effects of PFOS and PFOA on the human body. Through metabolomic analysis, several metabolites associated with PFOS and PFOA were identified, with lipids and xenobiotics being the most common types. These findings provide insights into the potential hazards of PFOS and PFOA.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Ling Chen, Yafeng Liu, Hongxin Mu, Huan Li, Su Liu, Mengyuan Zhu, Yuanqing Bu, Bing Wu
Summary: This study investigated the toxicity of low-dose PFBS on liver and compared it with PFOS. The results showed that PFBS exposure induced cell apoptosis and decreased CAT activities, while PFOS exposure led to accumulation of lipid droplets, increase of CAT activities, and TAG levels. Lipidomics analysis revealed similar global lipid changes in the two PFBS-treated groups, distinct from PFOS.
ENVIRONMENTAL POLLUTION
(2022)
Article
Engineering, Environmental
Sandra Nilsson, Jack Thompson, Jochen F. Mueller, Jennifer Braeunig
Summary: The study aims to estimate the apparent half-lives of Cl-PFOS and PFOS isomers in firefighters following the end of exposure to 3M-AFFF, analyzing paired serum samples from 120 firefighters.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Oncology
Vicky C. C. Chang, Jongeun Rhee, Sonja I. I. Berndt, Steven C. C. Moore, Neal D. D. Freedman, Rena R. R. Jones, Debra T. T. Silverman, Gretchen L. L. Gierach, Jonathan N. N. Hofmann, Mark P. P. Purdue
Summary: In this nested case-control study, prediagnostic serum levels of PFOS and PFOA were found to be associated with breast cancer risk, particularly for hormone receptor-positive tumors, providing evidence of a possible positive association.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Engineering, Environmental
Wei-Rong Wang, Pei-Yao Chen, Jie Deng, Yu Chen, Hua-Ji Liu
Summary: This study successfully prepared CD hydrogels that efficiently adsorb PFOS through their CD moieties, demonstrating excellent adsorption performance and cycling stability. In practical wastewater treatment, CD hydrogels can effectively remove PFOS and meet environmental protection standards.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Liquan Chu, Chaojie Zhang, Pei Chen, Qi Zhou, Xuefei Zhou, Yalie Zhang
Summary: In this study, UV/KI system was used to decompose and defluorinate PFOS. It was found that the system can effectively promote PFOS decomposition and defluorination at a lower concentration of hydrated electron source chemicals and a wider pH range. The decomposition process followed a pseudo-first-order model, and the main products were environmentally friendly ions and acids.
JOURNAL OF WATER PROCESS ENGINEERING
(2022)
Article
Environmental Sciences
Ying Pan, Bei Wen, Hongna Zhang, Shuzhen Zhang
Summary: This study investigated the uptake, translocation, and phytotoxicity of PFOS and 6:2 Cl-PFESA in mung bean plants. Results showed that 6:2 Cl-PFESA is more harmful to mung beans than PFOS, with hydroxyl radicals being the mechanism of toxicity.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Samuel Krebsbach, Jianzhou He, Sushil Adhikari, Yaniv Olshansky, Farshad Feyzbar, Leonard C. Davis, Tae-Sik Oh, Dengjun Wang
Summary: Biochar is a cost-effective solution for removing per- and polyfluoroalkyl substances (PFAS) from water, but the specific physicochemical properties of biochars that determine their PFAS removal remain unknown. In this study, 15 biochars were produced from five feedstocks at three pyrolysis temperatures to investigate their removal efficiency of perfluorooctane sulfonate (PFOS), a type of PFAS, from water. It was found that biochar pore diameter was the most critical factor for PFOS removal, but other factors such as pore diameter/pore volume ratio, specific surface area, pyrolysis temperature, hydrophobicity, and elemental composition also played roles. Biochars with small pore diameter, low nitrogen content, and high pyrolysis temperature showed enhanced PFOS sorption. These findings contribute to the understanding of using biochars with optimized properties to remove PFAS compounds from water.
Article
Chemistry, Multidisciplinary
Sheng-Nan Lei, Huan Cong
Summary: Sensitive and selective sensors for detecting trace PFOS in water are crucial due to its harmful effects. This study developed a fluorescent sensor based on BowtieCyclophane, achieving successful detection of PFOS with visual fluorescence color changes.
CHINESE CHEMICAL LETTERS
(2022)
Article
Environmental Sciences
Jun Hu, Yifan Qiu, Bing Gu, Nv Yao, Zimo Lou, Zhuowei Cheng, Xianzhao Zhang, Jianming Yu
Summary: This study investigates the role of magnetite (Fe3O4) in enhancing the milling performance of zero-valent iron (Fe) for the mechanochemical destruction (MCD) of perfluorooctane sulfonate (PFOS). The results show that Fe3O4 accelerates electron transfer, reacts with Fe to produce FeO, and facilitates the formation of HO·. HO· plays a dominant role in the defluorination process, accounting for more than 67% of PFOS degradation. After the elimination of the sulfonate group, the produced radical (C7F15CF2·) undergoes stepwise defluorination or oxidation reactions to yield aldehydes and carboxylic acids.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Ya Zhu, Dandong Yang, Xinbin Duan, Yongkang Zhang, Daqing Chen, Zhiyuan Gong, Chunsheng Liu
Summary: The study proved that PFOS could promote liver tumor progression, highlighting the need for attention to its tumor-promoting effects in assessing environmental health risks.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Lilong Jiang, Yanjun Hong, Pingting Xiao, Xiaoxiao Wang, Jinghui Zhang, Ehu Liu, Huijun Li, Zongwei Cai
Summary: This study demonstrated the critical role of the fecal microbiota in PFOS-induced liver injury in mice and identified several critical bacteria that could protect against liver injury induced by PFOS in male and female mice.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Agriculture, Multidisciplinary
Mengke Song, Longfei Jiang, Dayi Zhang, Zilin Huang, Shaorui Wang, Weiping Mei, Chunling Luo, Gan Zhang
Summary: The study found that the presence of different concentrations of copper (Cu) had varying effects on PFOS, with low concentrations causing an increase in PFOS concentration in roots and high concentrations damaging root cell membranes and increasing root permeability. It was also observed that Cu inhibition of carrier proteins could lead to the suppression of acropetal translocation of PFOS, and the presence of a protein-mediated uptake pathway was evidenced by enantiomer fraction (EF) results.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Environmental Sciences
Pingwei Wang, Dongge Liu, Shuqi Yan, Jiajing Cui, Yujun Liang, Shuping Ren
Summary: This study reviews the adverse effects of PFOS on liver tissue and function, providing a reference for further research on the toxicity of PFOS and liver injury caused by PFOS.
Article
Environmental Sciences
Huishan Zhang, Hemin Lu, Lin Yu, Jiexin Yuan, Shan Qin, Cong Li, Ren-Shan Ge, Haolin Chen, Leping Ye
Summary: The study suggests that gestational exposure to PFOS may impact lung development in offspring by reducing alveolar numbers, causing simplified alveolar structure and thickened alveolar septa. PFOS-treated animals also showed increased lung inflammation and up-regulated inflammasome associated proteins, as well as raised inflammatory cytokines, while down-regulating critical factors promoting alveolar development and pulmonary angiogenesis.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Ram B. Jain
Summary: This study analyzed data from NHANES for US adults aged 20 years and above to estimate cotinine levels among different groups of smokers. Results showed that males had higher cotinine levels in certain groups than females, and non-Hispanic black smokers had higher levels compared to non-Hispanic whites. Additionally, estimations were made for self-reported nonsmokers classified as smokers and smokers with missing self-reported data on tobacco product use.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Ram B. Jain
Summary: Analysis of data from the National Health and Nutrition Examination Survey for US adults aged 20 years and older between 2005 and 2016 showed variations in concentrations of arsenobetaine, monomethylarsonic acid, dimethylarsenic acid, and total arsenic in urine across different stages of renal function. Differences were observed in concentrations based on gender and racial/ethnic groups, with levels decreasing over the survey years.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Ram B. Jain
Summary: The study found that glomerular hyperfiltration has a significant impact on the concentrations of perfluoroalkyl acids, with hyperfiltrators generally having lower adjusted geometric means compared to normal filtrators across various disease groups. Male-female differences in adjusted geometric means were usually narrower for normal filtrators, and the disease group with hypertension only had the highest adjusted geometric means for every perfluoroalkyl acid. Additionally, among hyperfiltrators, the group with anemia only had the lowest adjusted geometric means for every perfluoroalkyl acid compared to other disease groups.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Ram B. Jain, Alan Ducatman
Summary: This study found a positive association between PFAS exposure and Apo B, especially in non-diabetic individuals not taking lipid lowering medications. Diabetic individuals showed a greater impact of lipid lowering medications on Apo B compared to non-diabetic populations. Further research is needed to replicate these findings in other populations and to explore mechanistic studies.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Ram B. Jain
Summary: The study revealed a negative association between blood cadmium concentrations and certain PFAAs, a positive association between blood lead concentrations and most PFAAs, and a positive association between blood total mercury concentrations and all PFAAs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Ram B. Jain
Summary: This study found higher cotinine concentrations in males than females for children, adolescent smokers, and nonsmoker adults. Non-Hispanic Blacks had lower concentrations of both cotinine and hydroxycotinine than non-Hispanic Whites for adult smokers, and the ratio of hydroxycotinine concentrations for those exposed to ETS at home compared to those not exposed was different for nonsmoker adults and adult smokers.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Ram B. Jain
Summary: The study evaluated the variations in concentrations of selected monohydroxy polycyclic aromatic hydrocarbons in urine across different stages of glomerular function, finding differences in how the kidneys process PAH metabolites among smokers and nonsmokers.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Ram B. Jain
Summary: The study analyzed data from 639 US children aged 3-11 years and found significant associations between PFAAs and blood lead and mercury levels, suggesting potential co-exposure to PFAAs and lead/mercury may lead to more severe neurodevelopmental deficits. Additional research is needed to further investigate the additive/synergistic neurodevelopmental deficits associated with co-exposures to PFAAs and lead/mercury.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Ram B. Jain
Summary: Exposure to cadmium and lead can cause oxidative stress and result in kidney and cardiovascular diseases. The antiaging protein klotho acts as an antioxidant. This study found that the concentrations of klotho were affected by cadmium and lead exposure, with an observed decrease in klotho concentrations during kidney dysfunction, particularly with blood cadmium concentrations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Ram B. Jain, Alan Ducatman
Summary: This study examined the associations between blood manganese and selenium with serum concentrations of perfluoroalkyl substances (PFAS). Among adults, blood manganese concentrations were inversely associated with serum concentrations of several PFAS, while blood selenium concentrations were positively associated with PFAS in adults and adolescents.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Ram B. Jain
Summary: This study analyzed data from the US National Health and Nutrition Examination Survey to investigate gender and racial/ethnic differences in PFHpS concentrations among US adults. The study found that males had significantly higher concentrations of PFHpS than females, and PFHpS concentrations followed an inverted U-shaped curve across different stages of kidney function.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Ram B. Jain, Alan Ducatman
Summary: This study used nationally representative data for US from 2003 to 2018 to analyze the gender-based differences in serum concentrations of PFAS. The results showed that females had lower serum PFAS levels than males at certain age ranges, and the differences were maximized at different ages for different compounds. The findings suggest the importance of separate analyses of male and female data, as well as stratified analysis for different time periods in females. The study also provides support for further research on the influences of gender differences in serum PFAS.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Ram B. Jain
Summary: Data from the National Health and Nutrition Examination Survey were analyzed to explore the relationships between certain fluorinated carbon compounds and urinary concentrations of arsenic. The results showed positive associations between PFNA and all four arsenic variables, with statistical significance observed only for IAS. PFDA and PFUnDA were positively associated with urinary arsenic, while Me-PFOSA with PFAS showed inverse associations, with significance observed only for UDMA. PFOA, PFHxS, and PFOS generally exhibited negative associations with arsenic, but without statistical significance. Further investigation is needed to understand the impact of co-exposure to PFAS and arsenic on health, with fluorinated carbon chain length potentially playing a role in defining these associations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Ram B. Jain
Summary: The associations between urinary concentrations of oxidant polycyclic aromatic hydrocarbon (PAH) metabolites and serum concentrations of anti-oxidant alpha-klotho were examined in US adults aged 40-79 years. The study found that increased PAH metabolite concentrations were associated with decreased alpha-klotho concentrations in individuals with normal or near normal kidney function. However, the associations were not significant in individuals with albuminuria. These findings suggest that exposure to PAH may lead to reduced alpha-klotho concentrations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Ram B. Jain
Summary: This study estimated the associations between urinary concentrations of oxidant polycyclic aromatic hydrocarbon (PAH) metabolites and serum concentrations of anti-oxidant alpha-klotho in US adults aged 40-79 years. The results showed that increased levels of certain PAH metabolites were associated with decreased serum alpha-klotho concentrations, especially in individuals without albuminuria and normal or near normal kidney function.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
