Review
Dermatology
G. Tavoletti, G. Avallone, C. Conforti, G. Roccuzzo, C. A. Maronese, M. A. Mattioli, P. Quaglino, I. Zalaudek, A. V. Marzano, S. Ribero, S. Alberti-Violetti
Summary: Vitiligo is a chronic autoimmune skin disorder with limited treatment options. Topical therapies, such as corticosteroids and calcineurin inhibitors, are preferred to systemic treatments due to their fewer side effects. Recently, a topical formulation of the selective JAK1/2 inhibitor ruxolitinib has been approved for the treatment of non-segmental vitiligo in patients aged >12 years. This review discusses the efficacy and safety of topical ruxolitinib, as well as issues related to its use in specific populations and treatment duration.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Paul Leighton, Joanne R. Chalmers, Jonathan M. Batchelor, Andy Rogers, Perways Akram, Rachel H. Haines, Garry D. Meakin, Jennifer White, Jane C. Ravenscroft, Tracey H. Sach, Miriam Santer, Maxine E. Whitton, Viktoria Eleftheriadou, Kim S. Thomas
Summary: The study shows that combination treatment is safe and effective for patients with active, limited vitiligo. Providing combination treatment requires collaboration with medical physics and ongoing training and support.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Julia-Tatjana Maul, Florian Anzengruber, Curdin Conrad, Antonio Cozzio, Peter Hausermann, Ahmad Jalili, Antonios G. A. Kolios, Emmanuel Laffitte, Anne-Karine Lapointe, Carlo Mainetti, Christoph Schlapbach, Ralph Trueeb, Nikhil Yawalkar, Michaela Dippel, Alexander A. Navarini
Summary: Topical treatment is crucial for the successful management of plaque psoriasis, with treatment goals defined together with the patient being crucial for treatment adherence. Swiss dermatologists provide current treatment options and tailored recommendations for specific areas through an expert opinion paper.
Article
Nutrition & Dietetics
Yujia Wei, Tingmei Wang, Xiaoqi Nie, Zeqi Shi, Zhong Liu, Ying Zeng, Ronghua Pan, Ri Zhang, Yunhua Deng, Dong Li
Summary: This study investigates the immunomodulatory effects of 1,25-dihydroxyvitamin D3 (1,25(OH)(2)D-3) in vitiligo. Deficiency of 1,25(OH)(2)D-3 is associated with hyperactivity of CD8+ T cells in vitiligo patients. 1,25(OH)(2)D-3 suppresses glycolysis and inhibits proliferation, cytotoxicity, and aberrant activation of CD8+ T cells.
Article
Dermatology
Radwa M. Bakr, Reham M. Abdel-Gaber, Yasmin M. Tawfik
Summary: For patients with stable nonsegmental vitiligo, the combination of fractional CO2 laser and NB-UVB phototherapy was found to be most effective in achieving repigmentation, with significantly better outcomes compared to other treatment modalities.
DERMATOLOGIC THERAPY
(2021)
Review
Immunology
Mengjie Hu, Kexin Liao, Wenyi Lei, Rongxin Zhang, Caixia Tu
Summary: The combination of phototherapy and topical calcipotriol demonstrates significantly higher efficacy in treating vitiligo compared to phototherapy alone, with minor, transient, and tolerable side effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Cunhua Xu, LiLi Lan, Zhao Wang, Peiwen Lv, Wei Zheng
Summary: In this study, AlSnO films were grown by the magnetron sputtering technique and different band gaps ranging from 4.40-5.43 eV were achieved. Solar-blind ultraviolet detectors were fabricated based on these films, demonstrating excellent spectral selectivity, detectivity, and narrow full widths at half-maximum in the response spectra. The fabrication of detectors via band gap engineering presented in this study can serve as a significant reference for researchers interested in solar-blind ultraviolet detection.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Immunology
Xiaowu Liu, Ziqian Yao, Yanchun Wang, Luyu Chai, Xu Zhou
Summary: This systematic review found that the combination of vitamin D analogs and phototherapy (NBUVB) is more effective than phototherapy alone for treating vitiligo, with tacalcitol showing greater efficacy than calcipotriol. However, the evidence does not support the use of vitamin D analogs in combination with PUVA or EL for vitiligo treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Sharon Zhao, Austin Hwang, Corinne Miller, Peter Lio
Summary: This systematic review synthesizes the clinical trial literature and concisely reports the safety and adverse effects of topical medications used to treat atopic dermatitis in children. The study found that tacrolimus, pimecrolimus, crisaborole, and delgocitinib are safe options with minimal adverse events for managing pediatric AD.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Michal A. Zmijewski
Summary: Vitamin D exhibits a variety of activities, including both classic pathway- and vitamin D receptor-dependent transcriptional modulation, as well as rapid and nongenomic responses. It has cell-protective effects, triggers calcium influx, modulates intracellular processes, and influences mitochondrial function. The mechanisms of these nongenomic responses are still not fully understood, but their impact on physiology, pathology, and potential clinical applications are discussed in this review.
Article
Biochemistry & Molecular Biology
Andrea Elmelid, Maria Siekkeri Vandikas, Martin Gillstedt, Amra Osmancevic, Mikael Alsterholm
Summary: Vitamin D plays an important role in skin inflammation in psoriasis, and UVB phototherapy can increase vitamin D levels. This study aimed to measure free serum 25(OH)D levels in psoriasis patients before and after phototherapy and determine if free 25(OH)D correlates stronger to disease severity than total 25(OH)D. The results showed that both total and free 25(OH)D levels increased after phototherapy and were positively correlated. However, no correlations between disease severity and vitamin D levels were found.
Article
Dermatology
S. Utz, V. G. A. Suter, S. Cazzaniga, L. Borradori, L. Feldmeyer
Summary: Topical tacrolimus is an effective therapy for oral lichen planus, especially for patients who are unresponsive to potent topical corticosteroids. Adjusting the treatment frequency based on signs of clinical activity and subjective impairment is important, with regular follow-up essential for early detection of potential squamous cell carcinoma.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Review
Genetics & Heredity
Aleksandra Bialczyk, Adam Welniak, Barbara Kaminska, Rafal Czajkowski
Summary: Vitiligo is a chronic skin disorder characterized by the loss of melanocytes and subsequent skin depigmentation. Oxidative stress has been identified as a potential factor in the pathogenesis of vitiligo, and antioxidant therapies may offer a promising approach to managing this condition.
MOLECULAR DIAGNOSIS & THERAPY
(2023)
Article
Agriculture, Dairy & Animal Science
Laure E. E. Molitor, Kelly Rockwell, Amelia Gould, Mark A. A. Mitchell
Summary: Vitamin D is an important hormone that can be obtained through diet or exposure to UVB radiation. Limited research has been conducted on the effects of UVB on domestic rabbits, but initial findings have shown that artificial UVB exposure for 12 hours can increase their vitamin D levels. This study aimed to determine if shorter-duration UVB exposure can have a similar effect. The results demonstrated that 6 hours of artificial UVB exposure over 14 days can indeed increase vitamin D levels in rabbits.
Review
Pharmacology & Pharmacy
Hua-Ching Chang, Siao-Pei Guo
Summary: This systematic review and meta-analysis examined the efficacy of local prostaglandin analogues in the treatment of vitiligo. The findings demonstrated that local prostaglandin analogues significantly increased repigmentation compared with other therapies, and their repigmentation efficacy was similar to that of topical tacrolimus. Therefore, local prostaglandin analogues can be considered safe and effective treatments for vitiligo.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2022)
