Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model

Selectivity in the impact of P-glycoprotein upon pulmonary absorption of airway-dosed substrates: A study in ex vivo lung models using chemical inhibition and genetic knockout

(2013) Ghaith Al-Jayyoussi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Comparison of the bronchodilating effects of inhaled β2-agonists after methacholine challenge in a human lung reperfusion model

(2012) Mirjam Gnadt et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Dry Powder Inhalation Exposures of the Endotracheally Intubated Rat Lung, Ex Vivo and In Vivo: The Pulmonary Pharmacokinetics of Fluticasone Furoate

(2012) Ewa Selg et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Methacholine delays pulmonary absorption of inhaled β2-agonists due to competition for organic cation/carnitine transporters

(2012) Mirjam Gnadt et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity

(2011) Robert J. Young et al.   DRUG DISCOVERY TODAY

Enhancing the Intestinal Membrane Permeability of Zanamivir: A Carrier Mediated Prodrug Approach

(2011) Sheeba Varghese Gupta et al.   MOLECULAR PHARMACEUTICS

Probing the links between in vitro potency, ADMET and physicochemical parameters

(2011) M. Paul Gleeson et al.   NATURE REVIEWS DRUG DISCOVERY

A new methodology for predicting human pharmacokinetics for inhaled drugs from oratracheal pharmacokinetic data in rats

(2011) Rhys M. Jones et al.   XENOBIOTICA

Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination

(2010) Manthena V. S. Varma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dissolution in nasal fluid, retention and anti-inflammatory activity of fluticasone furoate in human nasal tissueex vivo

(2009) D. Baumann et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

(2009) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Physicochemical drug properties associated within vivotoxicological outcomes: a review

(2009) David A Price et al.   Expert Opinion on Drug Metabolism & Toxicology

Analysis of the Calculated Physicochemical Properties of Respiratory Drugs: Can We Design for Inhaled Drugs Yet?

(2009) Timothy J. Ritchie et al.   Journal of Chemical Information and Modeling

Drug transporters in the lung—do they play a role in the biopharmaceutics of inhaled drugs?

(2009) Cynthia Bosquillon   JOURNAL OF PHARMACEUTICAL SCIENCES

Preclinical Evaluation of Long-Acting Muscarinic Antagonists: Comparison of Tiotropium and Investigational Drugs

(2009) P. Casarosa et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Physiochemical drug properties associated with in vivo toxicological outcomes

(2008) Jason D. Hughes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

(2008) M. Paul Gleeson   JOURNAL OF MEDICINAL CHEMISTRY