Article
Biochemistry & Molecular Biology
Janice Taile, Matthieu Bringart, Cynthia Planesse, Jessica Patche, Philippe Rondeau, Bryan Veeren, Patricia Clerc, Anne Gauvin-Bialecki, Steeve Bourane, Olivier Meilhac, David Couret, Marie-Paule Gonthier
Summary: This study evaluated the effects of polyphenols extracted from Antirhea borbonica on obesity and diabetes-related cerebrovascular damages during stroke. The results showed that polyphenols reduced insulin resistance, hyperglycemia, and dyslipidemia caused by obesity, and attenuated brain infarct, hemorrhagic transformation, and blood-brain barrier disruption. Polyphenols also exhibited anti-inflammatory and antioxidant properties, and decreased MMP-2 activity in hyperglycemic condition. Furthermore, the protective effects of polyphenols were associated with their circulating metabolites.
Article
Chemistry, Multidisciplinary
Elena Morosan, Magdalena Mititelu, Doina Draganescu, Dumitru Lupuliasa, Emma Adriana Ozon, Oana Karampelas, Cerasela Elena Gird, Corina Arama, Marilena Viorica Hovanet, Adina Magdalena Musuc, Ana Corina Ionita
Summary: This study aims to investigate the antioxidant activity of a new pharmaceutical product containing natural antioxidants extracted from plant raw materials. Experimental results show significant antioxidant potential in both the analyzed plant extractive solutions and the final product.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, Research & Experimental
Karolina Jakubczyk, Aleksandra Tuchowska, Katarzyna Janda-Milczarek
Summary: Hydrolates, by-products of plant hydrodistillation, have high antioxidant potential depending on plant species, origin, plant part, and preservation method. The study demonstrates the wide application of hydrosols in cosmetics and their potential value in skincare and agri-food industry.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Nutrition & Dietetics
Beata Olas
Summary: English Summary: Graviola, a plant found in tropical regions, has various ethnomedicinal uses such as treating insomnia, diabetes, cystitis, and headaches. It contains active components called annonaceous acetogenins, with over 100 compounds isolated from it. Graviola is also a source of phenolic compounds, essential oils, alkaloids, flavonol triglycosides, and megastigmanes, as well as several minerals. This paper provides an overview of the antioxidant properties of graviola and its major constituents, based on a review of electronic databases, but more research is needed to determine its antioxidant potential and safety.
Article
Food Science & Technology
Raiyan Mahbub, Nidhish Francis, Christopher L. Blanchard, Abishek B. Santhakumar
Summary: The study found that chickpea hull phenolic extracts (CHPE) can alleviate oxidative stress and inflammation by increasing the activity of antioxidant enzymes and reducing the production of inflammatory markers. The results suggest that CHPE may have potential as a treatment for chronic inflammation.
Review
Biochemistry & Molecular Biology
Shubhadeep Roychoudhury, Barnali Sinha, Birupakshya Paul Choudhury, Niraj Kumar Jha, Partha Palit, Surekha Kundu, Subhash C. Mandal, Adriana Kolesarova, Mokhtar Ibrahim Yousef, Janne Ruokolainen, Petr Slama, Kavindra Kumar Kesari
Summary: Para-coumaric acid (p-CA) is a plant-derived secondary metabolite with various bioactivities, including antioxidant, anti-inflammatory, and anti-cancer properties. Studies have shown that p-CA can mitigate the effects of diseases caused by oxidative stress and has therapeutic potential.
Article
Food Science & Technology
Cristiane de Freitas Rodrigues, Jean Ramos Boldori, Marcell Valandro Soares, Sabrina Somacal, Tatiana Emanuelli, Aryele Izaguirry, Francielli Weber Santos Cibin, Paula Rossini Augusti, Cristiane Casagrande Denardin
Summary: Goji berry juice exerts toxic effects on Caenorhabditis elegans, promoting premature aging. Further studies in mammals are needed before its consumption can be recommended.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Plant Sciences
Yajie Wang, Yue Chen, Yanan Jia, Zihan Xue, Zhongqin Chen, Min Zhang, Pharkphoom Panichayupakaranant, Shuyu Yang, Haixia Chen
Summary: Chrysophyllum cainito leaves have promising antioxidant, hypoglycemic, and antiglycation activities, making them a potential candidate for treating diabetes and associated chronic diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Chouari Zhor, Lounis Wafaa, Imen Ghzaiel, Khadidja Kessas, Amira Zarrouk, Mohamed Ksila, Taoufik Ghrairi, Norbert Latruffe, Olfa Masmoudi-Kouki, Adil El Midaoui, Dominique Vervandier-Fasseur, Mohamed Hammami, Gerard Lizard, Anne Vejux, Omar Kharoubi
Summary: Aging leads to the deterioration of cellular functions and increases the risk of age-related diseases. Cardiovascular diseases, some neurological disorders, and cancers are among the diseases that affect lifespan and are associated with accumulated cellular damage and reduced stress response pathways. Inflammation and oxidative stress, key factors in the aging process, result from these processes. Edible plants have gained interest for their potential therapeutic effects in preventing age-related diseases. The beneficial effects of these foods are attributed, in part, to their high concentration of bioactive phenolic compounds, particularly antioxidants, which are associated with slower aging. Human dietary intervention studies strongly support the protective role of polyphenol supplementation in preventing age-related diseases.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pedro Ferreira-Santos, Antonio Nogueira, Cristina M. R. Rocha, Cristina Pereira Wilson, Jose A. Teixeira, Claudia Botelho
Summary: The bioavailability and toxicological effects of S. nigra extracts, specifically from flower and berry, were found to differ significantly, with the berry extract showing better antioxidative effects post-digestion and lower cytotoxicity. These findings suggest the potential of S. nigra by-product compounds as functional food ingredients or bio-therapeutic agents.
Review
Biochemistry & Molecular Biology
Iram Iqbal, Polrat Wilairatana, Fatima Saqib, Bushra Nasir, Muqeet Wahid, Muhammad Farhaj Latif, Ahmar Iqbal, Rabia Naz, Mohammad S. Mubarak
Summary: Fruits, vegetables and other food items contain phytochemicals which have medicinal importance and can prevent and treat various diseases. Polyphenols found in these foods have numerous health benefits, such as immune modulation, vasodilation and antioxidant effects. Recent studies have shown that dietary polyphenols, such as kaempferol, quercetin, and resveratrol, can treat cardiovascular disorders, atherosclerosis and vascular endothelium deficits, by preventing oxidative stress, regulating endothelial function and suppressing inflammation.
Article
Biochemistry & Molecular Biology
Bryan Veeren, Matthieu Bringart, Chloe Turpin, Philippe Rondeau, Cynthia Planesse, Imade Ait-Arsa, Fanny Gimie, Claude Marodon, Olivier Meilhac, Marie-Paule Gonthier, Nicolas Diotel, Jean-Loup Bascands
Summary: The study shows that the polyphenol-rich extract from A. borbonica, as well as CA, can significantly improve renal tubulointerstitial fibrosis progression in the UUO mouse model through reducing macrophage infiltration, myofibroblast appearance, and extracellular matrix accumulation. Additionally, this effect is associated with the down-regulation of Tgf-beta, Tnf-alpha, Mcp1 and NfkB, as well as the upregulation of Nrf2, and an increased antioxidant enzyme activity for GPX and Cu/ZnSOD.
Article
Biochemistry & Molecular Biology
Mingxin Ye, Hui Li, Hongjun Luo, Yongyin Zhou, Wenhong Luo, Zhexuan Lin
Summary: This study found that erythrocytes metabolize methionine to homocysteine, which enhances the antioxidative capability of erythrocytes and protects them against damage from reactive oxygen species.
Article
Multidisciplinary Sciences
Ang Lu, Shi-meng Yuan, Huai Xiao, Da-song Yang, Zhi-qiong Ai, Qi-Yan Li, Yu Zhao, Zhuang-zhi Chen, Xiu-mei Wu
Summary: This study used QSAR to investigate the relationship between molecular descriptors, physicochemical properties, and antioxidant activity of polyphenol analogues, providing guidance for the design and discovery of highly-potent antioxidants.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Glaucimeire R. Carvalho, Debora S. Braz, Talita C. O. Goncalves, Rafaela Aires, Larissa Z. Coco, Marcio Guidoni, Marcio Fronza, Denise C. Endringer, Antonio D. S. Junior, Manuel Campos-Toimil, Breno Nogueira, Elisardo C. Vasquez, Bianca P. Campagnaro, Thiago M. C. Pereira
Summary: The VO resin extract has shown promising effects in wound healing by promoting re-epithelialization through antioxidant mechanisms.
Article
Biochemistry & Molecular Biology
Abderrahim Benkhaled, Yassine Reggami, Amel Boudjelal, Abderrahmane Senator, Hamama Bouriche, Ibrahim Demirtas, Abdelhakim Kheniche, Halima Benyettou, Nadia Larabi, Giuseppe Ruberto
Summary: This study chemically analysed and evaluated the effects of Limoniastrum guyonianum leaf extract on fructose-induced metabolic syndrome in rats. The results showed that the extract could ameliorate the metabolic abnormalities caused by fructose and protect the kidneys.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Chemistry, Applied
Ferda Eser, Muhammed Altun, Ibrahim Demirtas, Lutfi Behcet, Ebru Aktas
Summary: This study extracted the aerial parts of Nepeta teucriifolia using solvents with different polarities and evaluated the antiproliferative activities of the extracts against rat brain tumor and human cervix carcinoma cell lines. The CH2Cl2 and EtOAc extracts showed significant antiproliferative activities against HeLa cells at higher concentrations. Phytochemical studies of the active CH2Cl2 extract led to the discovery of three new iridoids.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Organic
Ibrahim Demirtas, Mehmet Fatih Birinci, Yakup Budak, O. M. E. R. ANDAC, O. G. U. Z. OZBEK, W. I. L. L. I. A. M. T. A. HARRISON
Summary: Trityl-type new protecting groups were easily prepared from the reaction of 1-bromonaphthalene or 2-bromonaphthalene and 4-methoxy substituted benzophenones following the Grignard reaction. These protecting groups exhibited good selectivity in the reactions and had advantages such as low solvent use and simple procedures.
ORGANIC COMMUNICATIONS
(2022)
Article
Plant Sciences
Ayse Sahin Yaglioglu, Muhammet Samil Yaglioglu, Nahide Tosyalioglu, Sevki Adem, Ibrahim Demirtas
Summary: The bioactive components and anticancer activities of four unexamined Abies species in Anatolia were investigated in this study. The results showed that solvent polarity affected the composition and anticancer activity of the extracts. The identified major components included gentisic acid, catechin, palmitic acid, stearic acid, oleic acid, caryophyllene, caryophyllene oxide, and eicosene. The analysis indicated that these compounds have effective anticancer activity against HeLa and C6 cells and potential drug properties.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Necmettin Aktepe, Ayse Baran, Mehmet Nuri Atalar, Mehmet Firat Baran, Cumali Keskin, Abdullah Taskin, Oemer Yavuz, Ibrahim Demirtas, Ercan Oguz, Israt Jahan
Summary: This study investigated the phenolic content, antimicrobial effects, and cytotoxic effects of extracts from Cyclotrichium origanifolium. Phenolic compounds were analyzed using liquid chromatography-electrospray ionization-tandem mass spectrometry. The extracts were tested for antimicrobial activity against Pseudomonas aeruginosa and Candida albicans using the minimum inhibition concentration method. Cytotoxicity analysis was performed on human dermal fibroblasts, glioblastoma cells, ovarian adenocarcinoma cells, and human colorectal adenocarcinoma cells. The extracts also showed a decrease in GST and AChE enzyme activities.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Burcin Vurucu, Samet Mert, Serkan Koldas, Ibrahim Demirtas, Rahmi Kasimogullari
Summary: A series of novel N-methyl-substituted pyrazole carboxamide and dicarboxamide derivatives were synthesized efficiently. The synthesized sulfonamide derivatives were characterized using various spectroscopic techniques. The antiproliferative activities of the synthesized compounds were evaluated against HeLa cell line, and compound 16 showed the highest activity among them.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2023)
Article
Food Science & Technology
Hiba H. S. Omer, Ibrahim Demirtas, Tevfik Ozen
Summary: The study evaluated the effects of low-temperature extraction of pulverized propolis extract on extraction yield, chemical composition, and biological activity. The results showed that PP-80 and PP-196 extracts are rich in phenolic components and possess high antioxidant, antibacterial, enzyme inhibition, and DNA protective activities.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Biochemistry & Molecular Biology
Semiha Yenigun, Yasar Ipek, Sarmad Marah, Ibrahim Demirtas, Tevfik Ozen
Summary: Parietin was isolated from Xanthoria parietina (L.) Th. Fr.' (methanol:chloroform) extract and its structure was confirmed using NMR techniques. It was investigated for its antioxidant, antibacterial and DNA protective activities, as well as its binding affinity with enzymes through molecular docking. Parietin exhibited high metal chelating activity and showed potential in inhibiting various bacterial strains. The results of inhibition and kinetics studies confirmed its effectiveness against enzymes, making it suitable for application in the food and pharmaceutical industries.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Atiqur Rahman, Shah Alam Siddiqui, Muhammed Altun, Ibrahim Demirtas
Summary: The ethnomedicinal plant Premna integrifolia is widely used in Indian subcontinent for treating various ailments. The organic leaf extracts of PI contain phenolic compounds and volatile organic compounds, which exhibit strong anti-proliferative activities on human cervical cancer cell lines.
Article
Biochemistry & Molecular Biology
Semiha Yenigun, Yunus Basar, Yasar Ipek, Lutfi Behcet, Tevfik Ozen, Ibrahim Demirtas
Summary: Ursolic acid (UA) was isolated from several plant species using bioactivity-guided isolation and its content was determined. UA showed antioxidant and DNA protection activities, but exhibited low inhibitory effects on various enzymes. Therefore, UA can serve as a potential antioxidant, DNA protector, and enzyme inhibitor.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Yunus Basar, Semiha Yenigun, Yasar Ipek, Lutfi Behcet, Fatih Gul, Tevfik Ozen, Ibrahim Demirtas
Summary: 1,5,9-epideoxyloganic acid (ELA) was successfully isolated and purified from the crude extract of Nepeta aristata. ELA exhibited significant enzyme inhibition and DNA protection activities, particularly against acetylcholinesterase, butyrylcholinesterase, and alpha-glucosidase.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Integrative & Complementary Medicine
Mehmet Nuri Atalar, Ramazan Erenler, Fikret Turkan, Mehmet Hakki Alma, Ibrahim Demirtas, Ayse Baran, Sevgi Irtegun Kandemir, Ayse Ilgin Kekec, Fatma Zerrin Saltan
Summary: In this study, a quantitative analysis of bioactive compounds in leaf, stem, and root extracts of Corchorus olitorius L. was conducted using LC-MS/MS. The results showed that cynarin and chlorogenic acid were the major products in leaf extract. The extracts from leaf, stem, and root exhibited significant inhibition activity against AChE and GST. The leaf extract displayed antibacterial activity against P. aeruginosa and showed good antiproliferative activity against Skov-3 cell lines.
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sara Boussaha, Somia Lassed, Ahmed B. Abdelwahab, Adel Krid, Muhammed Altun, Pr. Pierre Chalard, Pr. Jean Claude Chalchat, Gilles Figueredo, Pr. Djamila Zama, Pr. Ibrahim Demirtas, Pr. Samir Benayache, Pr. Fadila Benayache
Summary: In this study, the chemical composition of Perralderia coronopifolia essential oils was analyzed, and their anticancer and antioxidant activities were investigated. The major compounds in the essential oils showed inhibitory effects on cell proliferation and protected DNA against oxidative damage. Molecular docking study revealed the inhibitory mechanisms of the compounds, and ADMET properties evaluation and DFT calculations provided insights for designing new cancer drugs.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Multidisciplinary
Radia Ayad, Hatice Banu Keskinkaya, Mehmet Nuri Atalar, Mostefa Lefahal, Nabila Zaabat, El Hani Makhloufi, Ibrahim Demirtas, Warda Trifa, Salah Akkal, Kamel Medjroubi
Summary: This study investigates the photoprotective activity of Jurinea humilis plant extract, which is found to have high levels of polyphenols and antioxidant capacity.
CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY
(2023)
Article
Plant Sciences
Mustafa Abdullah Yilmaz, Abdulselam Ertas, Ismail Yener, Fatma Pinar Turkmenoglu, Ozge Tokul Olmez, Mehmet Ozturk, Muhammed Altun, Oguz Cakir, Abbas Tarhan, Mehmet Boga, Ibrahim Demirtas, Mehmet Hakki Alma, Hamdi Temel
Summary: This study evaluated the biological activities and chemical fingerprint profiles of twelve Achillea L. species. The results showed that A. kotschyi and A. nobilis species exhibited high antioxidant potential and total phenolic content. LC-MS/MS analysis revealed high concentrations of chlorogenic acid in these species. Additionally, Achillea species showed high cytotoxic activity against the HeLa cell line.
TURKISH JOURNAL OF BOTANY
(2022)