The pharmacology, toxicology and potential applications of arecoline: a review

Areca catechu L. (Arecaceae): A review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

(2015) Wei Peng et al.   JOURNAL OF ETHNOPHARMACOLOGY

In silico Assessment of Drug-like Properties of Alkaloids from Areca catechu L Nut

(2015) W Peng et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

Evaluation of Arecoline Hydrobromide Toxicity after a 14-Day Repeated Oral Administration in Wistar Rats

(2015) Xiaojuan Wei et al.   PLoS One

Arecoline-induced myofibroblast transdifferentiation from human buccal mucosal fibroblasts is mediated by ZEB1

(2014) Yu-Chao Chang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Arecoline is cytotoxic for human endothelial cells

(2014) Mafaz Ullah et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

The Hepatotoxicity and Testicular Toxicity Induced by Arecoline in Mice and Protective Effects of Vitamins C and E

(2014) Jianhong Zhou et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Arecoline inhibits and destabilizes agrin-induced acetylcholine receptor cluster formation in C2C12 myotubes

(2013) Yung-Fu Chang et al.   FOOD AND CHEMICAL TOXICOLOGY

Elevated Snail Expression Mediates Tumor Progression in Areca Quid Chewing-Associated Oral Squamous Cell Carcinoma via Reactive Oxygen Species

(2013) Shiuan-Shinn Lee et al.   PLoS One

Arecoline improves vascular endothelial function in high fructose-fed rats via increasing cystathionine-γ-lyase expression and activating KATP channels

(2012) Hong-yan Ling et al.   ACTA PHARMACOLOGICA SINICA

Oral submucous fibrosis: an overview of the aetiology, pathogenesis, classification, and principles of management

(2012) Gururaj Arakeri et al.   BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY

β-catenin expression in areca quid chewing-associated oral squamous cell carcinomas and upregulated by arecoline in human oral epithelial cells

(2012) Shiuan-Shinn Lee et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Arecoline-stimulated placenta growth factor production in gingival epithelial cells: modulation by curcumin

(2012) S-J Cheng et al.   ORAL DISEASES

Arecoline-induced death of human leukemia K562 cells is associated with surface up-modulation of TNFR2

(2011) Ying-Jung Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Arecoline stimulated Cyr61 production in human gingival epithelial cells: Inhibition by lovastatin

(2011) Yi-Ting Deng et al.   ORAL ONCOLOGY

Arecoline decreases interleukin-6 production and induces apoptosis and cell cycle arrest in human basal cell carcinoma cells

(2011) Li-Wen Huang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A preliminary report on the toxicity of arecoline on early pregnancy in mice

(2010) Shao-Tung Liu et al.   FOOD AND CHEMICAL TOXICOLOGY

Arecoline, a major alkaloid of the areca nut, causes neurotoxicity through enhancement of oxidative stress and suppression of the antioxidant protective system

(2010) Yu-Tzu Shih et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hemeoxygenase-1 expression in response to arecoline-induced oxidative stress in human umbilical vein endothelial cells

(2010) Thu-Ching Hung et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Arecoline and oral keratinocytes may affect the collagen metabolism of fibroblasts

(2010) Li Xia et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Ultrastructural and hormonal modulations of the thyroid gland following arecoline treatment in albino mice

(2010) Romi Dasgupta et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Effects of arecoline on adipogenesis, lipolysis, and glucose uptake of adipocytes—A possible role of betel-quid chewing in metabolic syndrome

(2010) Hsin-Fen Hsu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Systemic Administration of Arecoline Reduces Ethanol-Induced Sleeping Through Activation of Central Muscarinic Receptor in Mice

(2009) Yan-Ping Sun et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Muscarinic receptor 1 agonist activity of novel arecoline derivatives in Alzheimer's dementia models

(2009) K.S. Rangappa   Alzheimers & Dementia

Co-treating with arecoline and 4-nitroquinoline 1-oxide to establish a mouse model mimicking oral tumorigenesis

(2009) Nai-Wen Chang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Betel nut chewing during pregnancy, Madang province, Papua New Guinea

(2009) M. Senn et al.   DRUG AND ALCOHOL DEPENDENCE

Arecoline-induced phosphorylated p53 and p21WAF1protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells

(2009) Wen-Wen Chou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Transglutaminase-2 Regulation by Arecoline in Gingival Fibroblasts

(2009) G.S. Thangjam et al.   JOURNAL OF DENTAL RESEARCH

Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes

(2009) G. S. Thangjam et al.   JOURNAL OF PERIODONTAL RESEARCH

Augmented heme oxygenase-1 expression in areca quid chewing-associated oral submucous fibrosis

(2009) C-H Tsai et al.   ORAL DISEASES

Associations between betel nut (Areca catechu) and symptoms of schizophrenia among patients in Nepal: A longitudinal study

(2009) Alicia Bales et al.   PSYCHIATRY RESEARCH

Effects of arecoline on testosterone release in rats

(2008) Shyi-Wu Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Arecoline, a major alkaloid of areca nut, inhibits p53, represses DNA repair, and triggers DNA damage response in human epithelial cells

(2008) Yi-Shan Tsai et al.   TOXICOLOGY

Effect of novel arecoline thiazolidinones as muscarinic receptor 1 agonist in Alzheimer's dementia models

(2007) J.N. Narendra Sharath Chandra et al.   NEUROCHEMISTRY INTERNATIONAL

Arecoline-induced growth arrest and p21WAF1 expression are dependent on p53 in rat hepatocytes

(2007) Wen-Wen Chou et al.   TOXICOLOGY