Article
Environmental Sciences
S. Shruthi, K. Bhasker Shenoy
Summary: This study evaluated the genoprotective effects of gallic acid (GA) against cyclophosphamide (CP) induced genotoxicity in Swiss albino mice. The results showed that GA significantly reduced DNA damage and micronucleus frequency caused by CP, as well as protected the hepatic tissue against reactive oxygen species (ROS) mediated damage. GA also ameliorated histological changes induced by CP in hepatic tissue, indicating its potential as a versatile antioxidant for protection against CP induced genotoxicity and hepatic damage in Swiss albino mice.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Amani M. T. Gusti, Safaa Y. Qusti, Eida M. Alshammari, Eman A. Toraih, Manal S. Fawzy
Summary: The study investigated the association of 12 SNPs related to antioxidants with obesity susceptibility in a Saudi population. Results suggest that genetic determinants related to oxidative stress could significantly associate with obesity risk in the study population.
Article
Environmental Sciences
Ana Luisa Pires Moreira, Weslley Souza Paiva, Augusto Monteiro de Souza, Maria Clara Galvao Pereira, Hugo Alexandre Oliveira Rocha, Silvia Regina Batistuzzo de Medeiros, Ana Carolina Luchiari
Summary: In this study, the effects of the UV filter BP-3 on brain performance in zebrafish were investigated. The results showed that BP-3 exposure caused redox imbalance and impaired learning and memory in zebrafish. Therefore, there is a need to replace toxic UV filters with filters that minimize environmental effects.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cen Luo, Wenjuan Xu, Xun Tang, Xinyu Liu, Yu Cheng, Yixun Wu, Zhengsong Xie, Xiaohong Wu, Xin He, Qian Wang, Yao Xiao, Xueting Qiu, Zhurong Tang, Gaohai Shao, Xiaolin Tu
Summary: This study reveals that excessive iron can lead to osteoporosis by inducing ferroptosis and impairing osteoblast differentiation. Excessive iron increases the accumulation of intracellular labile iron, resulting in the generation of reactive oxygen species (ROS) and lipid peroxidation products (LPO), leading to ferroptosis. The study further demonstrates that iron inhibits osteoblast differentiation by suppressing the canonical Wnt signaling pathway. However, the use of iron chelator, Wnt agonist, or antioxidant can reverse these effects and restore osteoblast differentiation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Environmental Sciences
Minerva Najera-Martinez, Anabel Perez-Cruz, Ricardo Dzul-Caamal, Armando Vega-Lopez
Summary: This study aimed to evaluate the impact of heavy metals on freshwater phytoplankton communities and their relationships with biomarkers of oxidative stress response. The results from artificial lakes and a natural lake showed different influence patterns.
WATER AIR AND SOIL POLLUTION
(2021)
Article
Chemistry, Multidisciplinary
Vinay Bharadwaj Tatipamula, Biljana Kukavica
Summary: This study investigated the protective effects of extracts from lichen Dirinaria consimilis against the toxicity of insecticides bifenthrin and diazinon. The results showed that the extracts acted as antioxidants and reduced oxidative stress burden caused by the insecticides.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ameer Alakkal, Faisal Thayyullathil, Siraj Pallichankandy, Karthikeyan Subburayan, Anees Rahman Cheratta, Sehamuddin Galadari
Summary: Sanguinarine induces cell death in human cervical cancer cells through activation of both apoptosis and ferroptosis pathways. Apoptosis is characterized by caspase activation and PARP cleavage, while ferroptosis involves SLC7A11 down-regulation, GSH depletion, iron accumulation, and lipid peroxidation. These findings suggest that apoptosis and ferroptosis act as partners in Sanguinarine-mediated tumor suppression. Additionally, Sanguinarine increases the generation of reactive oxygen species (ROS), and inhibiting ROS blocks the induction of both apoptosis and ferroptosis.
Article
Engineering, Environmental
Salim Ali, Suranjan Sikdar, Shatarupa Basak, Modhusudan Mondal, Kangkan Mallick, Md Salman Haydar, Shibaji Ghosh, Mahendra Nath Roy
Summary: Nanozymes serve as an alternative to natural enzymes, overcoming the drawbacks of bio enzymes. Recent research focuses on developing multi enzyme mimic nanomaterials for multifunctional applications in biomedical, biosensing, and sustainable chemistry fields.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Tao Jiang, Carlo Alberto Amadei, Yishan Lin, Na Gou, Sheikh Mokhlesur Rahman, Jiaqi Lan, Chad D. Vecitis, April Z. Gu
Summary: This study comprehensively assessed GO toxicity and its dependence on oxidation level, elemental composition, and size, revealing that elemental composition and size do exert impacts on GO toxicity, while oxidation level does not. UV-treated GO showed higher toxicity levels, especially in protein and chemical stress categories, while sonicated GOs displayed increased toxicity levels with decreasing size, suggesting that the covering and subsequent internalization of GO sheets may be the main mode of action in yeast cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Walaa Alharbi, Iftekhar Hassan, Rais Ahmad Khan, Shazia Parveen, Khadijah H. Alharbi, Ibtisam I. Bin Sharfan, Ibrahim M. Alhazza, Hossam Ebaid, Ali Alsalme
Summary: Biocompatible tryptophan-derived copper and zinc complexes were designed, synthesized, and evaluated for potential anticancer activity in vitro and in vivo. The results demonstrated decent selectivity and regulation of oxidative stress pathways in cancer cells.
Article
Biochemistry & Molecular Biology
Lu-Lu Bai, Lu-Qing Zhang, Jun Ma, Jing Li, Meng Tian, Rang-Juan Cao, Xiao-Xiao He, Zi-Xuan He, Hua-Li Yu, Xiao-Juan Zhu
Summary: The study revealed the important role of DIP2A in regulating oxidative stress in patients with Autism Spectrum Disorder, by inhibiting SOD activity and increasing ROS levels to protect cells from damage, while also affecting mitochondrial morphology and metabolism.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Horticulture
Faisal Zulfiqar, Anam Moosa, Antonio Ferrante, Muhammad Nafees, Anastasios Darras, Muhammad Mudassir Nazir, Manal Abdullah Alshaqhaa, Fahmy Gad Elsaid
Summary: This study found that the combined application of melatonin and salicylic acid can improve the tolerance of Gladiolus grandiflorus to arsenic toxicity. The combined application had a more pronounced effect in alleviating arsenic-induced oxidative stress in plants compared to individual application.
SCIENTIA HORTICULTURAE
(2023)
Article
Physiology
Elena Gorokhova, Rehab El-Shehawy
Summary: The study investigated the physiological responses of Baltic copepods to a diet of toxin-producing cyanobacteria and high-quality food, finding that feeding activity, RNA content, and egg production rate increased with food availability, while antioxidant enzyme activities were elevated regardless of diet type. A bimodal response in AChE was observed in copepods feeding on cyanobacteria, highlighting the importance of considering antioxidant and AChE responses in biomarker profiles for assessing environmental stress in the Baltic Sea.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eun-Nam Kim, Ga-Ram Kim, Jae Sik Yu, Ki Hyun Kim, Gil-Saeng Jeong
Summary: The study found that BAG can inhibit osteoclast differentiation and ROS production, restore the expression of antioxidant enzymes, suppress the phosphorylation of MAPKs and translocation of NF-kappa beta, and restore the mineralization of lost osteoblasts, suggesting its potential as a new natural product-derived treatment for bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jay L. Zweier, Craig Hemann, Tapan Kundu, Mohamed G. Ewees, Sahar A. Khaleel, Alexandre Samouilov, Govindasamy Ilangovan, Mohamed A. El-Mahdy
Summary: Cytoglobin (Cygb) has potent superoxide dismutase (SOD) function, rapidly dismutating superoxide in cells to protect against oxidative stress. Its role in cellular superoxide metabolism is important due to its ubiquitous expression in cells at micromolar concentrations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Environmental
Nan Jiang, Peipei Song, Xianxu Li, Lusheng Zhu, Jinhua Wang, Xianqiang Yin, Jun Wang
Summary: The study found that low concentrations of DBP can cause oxidative damage and genotoxicity in the zebrafish brain, demonstrating clear toxic effects. Assessment of DBP's toxic effects on zebrafish brain can be effectively evaluated by measuring biomarkers such as SOD and CAT activities.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Environmental
Lingxi Han, Tong Liu, Kuan Fang, Xianxu Li, Xiangwei You, Yiqiang Li, Xiuguo Wang, Jun Wang
Summary: This study investigated indigenous functional microbial communities associated with the degradation of chloroacetamide herbicides in soil. Biodegradation was found to be the main process for the degradation of ACE, S-MET and their enantiomers, with specific bacterial genera like Amycolatopsis and Saccharomonospora playing key roles in the preferential degradation of the S-enantiomers.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Zikun Dong, Xiaojing Yan, Jinhua Wang, Lusheng Zhu, Jun Wang, Chenyu Li, Wenjie Zhang, Shengfang Wen, Young Mo Kim
Summary: This study isolated a bacterium Bacillus cereus H38 that can use sulfamethazine (SMZ) as its only carbon source, and investigated the effects of environmental factors on the biodegradation of SMZ. The results showed that the maximum degradation rate of SMZ was achieved under the conditions of an initial SMZ concentration of 5 mg/L, pH of 7.0, temperature of 25 degrees C and inoculation amount of 5%. The study also identified possible intermediates and proposed two degradation pathways.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Physical
Lingsong Wang, Huanshun Yin, Suo Wang, Jun Wang, Shiyun Ai
Summary: Bi/BiOCl/Bi2O2CO3 heterojunction with enhanced photocatalytic activity was prepared via one-step hydrothermal process under the synergistic catalysis of Ni2+, showing promising application potential in environmental remediation.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Engineering, Environmental
Peipei Song, Nan Jiang, Kaiqu Zhang, Xianxu Li, Na Li, Youai Zhang, Qian Wang, Jun Wang
Summary: This study used zebrafish as a model to investigate the ecotoxicological effects of DBP, revealing oxidative stress, lipid peroxidation, and DNA damage in zebrafish liver. The results suggest that DBP poses significant potential risks to aquatic organisms.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Youai Zhang, Zhongkang Yang, Xianxu Li, Peipei Song, Jun Wang
Summary: This study revealed the toxic mechanism of DINP on earthworms, including its effects on ROS levels, MDA content, and antioxidant enzyme activity, as well as its impact on the gut bacteria of earthworms and surrounding soil bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Xianxu Li, Na Li, Can Wang, Anyu Wang, Wenjia Kong, Peipei Song, Jun Wang
Summary: This study investigated the occurrence of phthalic acid esters (PAEs) in protected agriculture soils and assessed their potential health risks to humans. The results showed that DEHP and DBP were the most abundant PAEs found in the soils, while DMP and DEP were not detected. Health risk assessment revealed that children have higher health risks compared to adults.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2022)
Article
Environmental Sciences
Zhongkun Du, Kaixuan Hou, Tongtong Zhou, Baihui Shi, Cheng Zhang, Lusheng Zhu, Bing Li, Jinhua Wang, Jun Wang
Summary: This study found that PHCZs cause cardiac developmental toxicity and behavioral changes in fish, while disrupting multiple pathways linked to organ development, immunization, metabolism, and protein synthesis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Jingwen Zhang, Cheng Zhang, Yong Zhang, Zhongkun Du, Bing Li, Jinhua Wang, Jun Wang, Lusheng Zhu
Summary: A study found that the widely used fungicide fluoxastrobin accumulates in soil and exhibits greater toxicity in natural soils, particularly in alkaline soils. Transcriptomics analysis revealed that exposure to fluoxastrobin leads to differential gene expression in earthworms, mainly associated with protein folding, immunity, signal transduction, and cell growth pathways. This study fills gaps in the literature regarding soil bio-toxicity of strobilurin fungicides and raises alarm about the application of such fungicides even at low concentrations (0.1 mg kg-1).
Article
Environmental Sciences
Xiaohui Ji, Xiangfeng Yao, Xianxu Li, Lusheng Zhu, Jinhua Wang, Jun Wang
Summary: The aim of this study was to investigate the effects of environmental concentrations of atrazine on the soil microbial community. The results showed that the number of culturable bacteria, fungi, and actinomycetes decreased significantly with the increase of atrazine concentration, showing a certain dose-effect relationship. Overall, this study demonstrates that atrazine has a certain influence on soil microorganisms and provides an objective assessment of the ecological risk of atrazine to soil microorganisms.
WATER AIR AND SOIL POLLUTION
(2023)
Article
Soil Science
Jingwen Zhang, Cheng Zhang, Yong Zhang, Zhongkun Du, Bing Li, Jinhua Wang, Jun Wang, Lusheng Zhu
Summary: This study used proteomics to investigate the toxicity mechanism of FLUO on earthworms in fluvoaquic soils, and found that differentially expressed proteins mainly involved signal molecules interactions, immunity, and cell death, causing stress and affecting the basic physiological activities of earthworms. This research enriched the toxicological data of FLUO and provided evaluation methods for the toxicity mechanism of FLUO for soil animals.
APPLIED SOIL ECOLOGY
(2023)
Article
Environmental Sciences
Meng Zhao, Congping Li, Cheng Zhang, Yujie Zhao, Xuexia Wang, Bing Cao, Li Xu, Jiajia Zhang, Jiachen Wang, Qiang Zuo, Yanhua Chen, Guoyuan Zou
Summary: This study systematically investigated the effects of polyurethane-coated microplastics (PU MPs) and Cd on rice growth and Cd accumulation. The results showed that the effects were concentration-dependent, and PU MPs enhanced Cd absorption in rice through influencing rhizosphere bacterial communities and metabolic pathways.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Environmental Sciences
Cheng Zhang, Xinru Wang, Parminder Kaur, Jay Gan
Summary: Neonicotinoids are widely used insecticides due to their effectiveness and low toxicity. However, their potential adverse effects on non-target species, especially pollinators, and their presence in the environment has raised concerns. Despite increasing research, our understanding of the toxicity and risks remains limited.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Environmental
Mengyao Yao, Jingran Qian, Xiaoni Chen, Jilong Liu, Xiaoqing Yang, Peng Gao, Cheng Zhang
Summary: Agricultural films are widely used in high-intensity agriculture, but the low recovery rate leads to an accumulation of plastic mulch in agricultural soils. This study focuses on the exposure impact of BBP, a chemical introduced into soil ecosystems through the accumulation of plastic mulch, on earthworms. The study explores the effects of BBP on the digestive system, oxidative stress, and neurotoxicity in earthworms, providing insights into the molecular mechanisms underlying these effects.
Article
Environmental Sciences
Cheng Zhang, Xiaoqing Yang, Zhangjia Wang, Yinglin Liu, Mengyao Yao, Lusheng Zhu, Peng Gao, Zhenyu Wang
Summary: This study assessed the co-exposure effects of butyl benzyl phthalate (BBP) and titanium dioxide nanomaterials (nTiO(2)) on Metaphire guillelmi, a soil organism. The results showed that BBP and nTiO(2) had detrimental effects on the gut and intestinal bacteria of Metaphire guillelmi. This study provides evidence for the sustainable application and scientific management of these compounds.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
