Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Using a Fragment-Based Approach To Target Protein-Protein Interactions

(2013) Duncan E. Scott et al.   CHEMBIOCHEM

Protein–protein interactions as druggable targets: recent technological advances

(2013) Alicia P Higueruelo et al.   CURRENT OPINION IN PHARMACOLOGY

Discovery of a Potent Inhibitor of Replication Protein A Protein–Protein Interactions Using a Fragment-Linking Approach

(2013) Andreas O. Frank et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nuclear trafficking of proteins from RNA viruses: Potential target for antivirals?

(2012) Leon Caly et al.   ANTIVIRAL RESEARCH

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

(2012) Kylie M. Wagstaff et al.   BIOCHEMICAL JOURNAL

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Toward the Rational Design of p53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant

(2010) Nicolas Basse et al.   CHEMISTRY & BIOLOGY

Novel Binding of the Mitotic Regulator TPX2 (Target Protein forXenopusKinesin-like Protein 2) to Importin-α

(2010) Astrid Giesecke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Therapeutic Targeting of Nuclear Protein Import in Pathological Cell Conditions

(2009) M. N. Chahine et al.   PHARMACOLOGICAL REVIEWS

Tumor Cell Dependence on Ran-GTP-Directed Mitosis

(2008) F. Xia et al.   CANCER RESEARCH

Six Classes of Nuclear Localization Signals Specific to Different Binding Grooves of Importin α

(2008) Shunichi Kosugi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RanGTP gradient - a GPS for the mitotic spindle

(2008) P. Kalab et al.   JOURNAL OF CELL SCIENCE