Screening and In Vitro Testing of Antifolate Inhibitors of Human Cytosolic Serine Hydroxymethyltransferase

SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation

(2014) A Paone et al.   Cell Death & Disease

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

(2014) J. Ye et al.   Cancer Discovery

Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis

(2012) Wen Cai Zhang et al.   CELL

In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed

(2011) Frederick Daidone et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nuclear Localization ofde NovoThymidylate Biosynthesis Pathway Is Required to Prevent Uracil Accumulation in DNA

(2011) Amanda J. MacFarlane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Cancer research: from folate antagonism to molecular targets

(2009) Joseph R. Bertino   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

SHMT1 and SHMT2 Are Functionally Redundant in Nuclear De novo Thymidylate Biosynthesis

(2009) Donald D. Anderson et al.   PLoS One

Structural and functional studies ofBacillus stearothermophilusserine hydroxymethyltransferase: the role of Asn341, Tyr60and Phe351in tetrahydrofolate binding

(2008) Vinitha R. Pai et al.   BIOCHEMICAL JOURNAL

Cytoplasmic Serine Hydroxymethyltransferase Regulates the Metabolic Partitioning of Methylenetetrahydrofolate but Is Not Essential in Mice

(2008) Amanda J. MacFarlane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY