Review
Chemistry, Analytical
Mylena Lemes Cunha, Stella Schuster da Silva, Mateus Cassaboni Stracke, Dalila Luciola Zanette, Mateus Nobrega Aoki, Lucas Blanes
Summary: Rapid and low-cost molecular analysis is crucial for early and specific diagnostics. Automated molecular diagnostic devices, such as sample-to-answer microfluidic devices, promise a complete molecular diagnosis system. The extraction process in such devices is laborious but important for sensitive and specific detection. Thus, researching automated or semiautomated extraction methodologies is beneficial for improving extraction procedures.
ANALYTICAL CHEMISTRY
(2022)
Review
Veterinary Sciences
Jobin Thomas, Ana Balseiro, Christian Gortazar, Maria A. Risalde
Summary: Animal tuberculosis, caused by the Mycobacterium tuberculosis complex, is a multi-host disease with significant impact on economy, industry, public health, and conservation. New approaches to wildlife TB diagnosis have gained importance in recent years. Immunological diagnostic tests based on immune response detection are becoming more crucial in wildlife TB diagnosis.
VETERINARY RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Renata Maia, Violeta Carvalho, Rui Lima, Graca Minas, Raquel O. Rodrigues
Summary: This systematic review summarizes the recent progress in the use of microneedles (MNs) in biomedical applications, including drug delivery, biomarker detection, and their potential integration with microfluidic devices. Although MNs have been extensively utilized in lab-on-a-chip platforms, recent studies have also explored their applicability in organ-on-a-chip models. Overall, the presence of MNs in advanced microfluidic devices offers simplified drug delivery, microinjection, and biomarker detection through integrated biosensors, enabling real-time monitoring of various biomarkers in lab- and organ-on-a-chip platforms.
Review
Public, Environmental & Occupational Health
Witchakorn Ruamtawee, Mathuros Tipayamongkholgul, Natnaree Aimyong, Weerawat Manosuthi
Summary: This study conducted a systematic review of the situation and risk factors for cardiovascular diseases (CVD) among people living with HIV in the Asia-Pacific region. The results showed a high risk of CVD among HIV-infected individuals in this region, particularly for early onset CVD. The study also found that the combination of traditional risk factors such as hypertension, diabetes, smoking, and HIV-specific risk factors significantly increased the risk of CVD among HIV-infected individuals.
Review
Medicine, General & Internal
McEwen Khundi, James R. Carpenter, Marriott Nliwasa, Ted Cohen, Elizabeth L. Corbett, Peter MacPherson
Summary: This study aimed to systematically evaluate the effectiveness of spatially targeted community public health interventions for HIV, tuberculosis, leprosy, and malaria. The results showed that studies investigating spatially targeted interventions were limited in number and often had methodological limitations, impacting the interpretation of intervention impacts. Applying advanced epidemiological methodologies supporting robust hotspot identification and larger or more intensive interventions would strengthen the evidence base for this important approach.
Review
Multidisciplinary Sciences
Hanna Vitaliyivna Denysyuk, Rui Joao Pinto, Pedro Miguel Silva, Rui Pedro Duarte, Francisco Alexandre Marinho, Luis Pimenta, Antonio Jorge Gouveia, Norberto Jorge Goncalves, Paulo Jorge Coelho, Eftim Zdravevski, Petre Lameski, Valderi Leithardt, Nuno M. Garcia, Ivan Miguel Pires
Summary: The prevalence of cardiovascular diseases is increasing globally. Advances in technology, such as low-cost sensors, enable continuous monitoring. This study presents a systematic review of 103 scientific papers on disease identification, classification, and recognition using ECG sensors. Different datasets and machine learning algorithms, such as Convolutional Neural Network and Support Vector Machine, have been identified. This review can inform the development of systems that empower patients.
Review
Geriatrics & Gerontology
Barbara de Oliveira Zanuso, Ana Rita de Oliveira dos Santos, Vitor Fernando Bordin Miola, Leila M. Guissoni Campos, Caio Sergio Galina Spilla, Sandra Maria Barbalho
Summary: The aging process can lead to various disorders and diseases, and Panax ginseng has shown therapeutic benefits in managing these conditions. The chemical constituents in ginseng have anti-inflammatory, antioxidant, and neuroprotective effects. Using ginseng as a complementary treatment can improve the quality of life for patients with chronic diseases related to aging.
EXPERIMENTAL GERONTOLOGY
(2022)
Review
Chemistry, Analytical
Nafisat Gyimah, Ott Scheler, Toomas Rang, Tamas Pardy
Summary: 3D printing technology shows potential in microfluidic chip fabrication and is mature enough for use in research labs. However, challenges still need to be overcome.
Review
Medicine, General & Internal
Katarzyna Kakareko, Alicja Rydzewska-Rosolowska, Edyta Zbroch, Tomasz Hryszko
Summary: TRAIL, a pro-apoptotic protein, may play a role in the pathophysiology of cardiovascular diseases, with evidence suggesting a link to all-cause mortality in patients. Further research is needed to clarify the exact association of TRAIL with cardiovascular diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Geriatrics & Gerontology
Can Hu, Xin Zhang, Teng Teng, Zhen-Guo Ma, Qi-Zhu Tang
Summary: This article discusses the mechanisms of cellular senescence in age-related cardiovascular diseases, highlighting the involvement of senescent cardiovascular cells and the targets regulating cellular senescence in cardiovascular disorders. It also reviews the evidence of both beneficial and detrimental implications of senescent cells in cardiovascular diseases, and summarizes the emerging pro-senescent or anti-senescent interventions and their therapeutic potential in preventing cardiovascular diseases.
Review
Health Care Sciences & Services
Erand Llanaj, Noushin Sadat Ahanchi, Helga Dizdari, Petek Eylul Taneri, Christa D. Niehot, Faina Wehrli, Farnaz Khatami, Hamidreza Raeisi-Dehkordi, Lum Kastrati, Arjola Bano, Marija Glisic, Taulant Muka
Summary: Evidence on the effects of buckwheat on cardiometabolic health is limited, but available literature suggests that buckwheat supplementation may have some benefits in lowering total cholesterol and glucose levels in individuals with mild metabolic disturbances and type 2 diabetes, although the effects are not significant. More rigorous trials with better methodological rigor are needed to further investigate the potential effects of buckwheat on cardiovascular disease risk markers.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Alexandru Burlacu, Crischentian Brinza, Iolanda Valentina Popa, Adrian Covic, Mariana Floria
Summary: HRV-biofeedback has positive effects on clinical outcomes in patients with CVD, reducing mortality and readmission rates, improving exercise capacity, and blood pressure control. Standard breathing protocols can yield similar results, and further research is needed on mortality in patients with coronary artery disease.
Article
Multidisciplinary Sciences
Abay Atnafu, Kassu Desta, Selfu Girma, Dawit Hailu, Gebeyehu Assefa, Shambel Araya, Dinksira Bekele, Liya Wassie, Kidist Bobosha
Summary: In this study, different methods for diagnosing tuberculosis lymphadenitis (TBLN) in suspected patients were evaluated. The results showed that FNA cytology and RT-PCR were able to identify TBLN cases better than other detection methods, and the combination of FNA cytology and GeneXpert MTB/RIF further improved the diagnostic sensitivity.
Review
Public, Environmental & Occupational Health
Fisaha Haile Tesfay, Christina Zorbas, Laura Alston, Kathryn Backholer, Steven J. Bowe, Catherine M. Bennett
Summary: This study conducted a systematic review and meta-analysis of the prevalence of non-communicable diseases (NCDs) in community settings in Ethiopia. The results showed that approximately one-third of Ethiopians have NCDs, with cardiovascular diseases being the most common. The prevalence of diabetes mellitus appears relatively low, but there is evidence of high prevalence of respiratory conditions. This study is important for guiding public health actions to address the burden of cardiovascular and respiratory diseases, as well as the increasing prevalence of diabetes in Ethiopia.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Food Science & Technology
Vitor Massami Imaizumi, Lucas Fornari Laurindo, Barbara Manzan, Elen Landgraf Guiguer, Marie Oshiiwa, Alda Maria Machado Bueno Otoboni, Adriano Cressoni Araujo, Ricardo Jose Tofano, Sandra Maria Barbalho
Summary: Garlic, with its bioactive compounds, has beneficial effects on cardiovascular risk factors and can be considered in their prevention and treatment.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Hematology
Klara Greffin, Holger Muehlan, Samuel Tomczyk, Ariane Suemnig, Silke Schmidt, Andreas Greinacher
Summary: This pilot study examined how deferral affects momentary mood, satisfaction with the donation process, and subsequent return behavior. Results showed that mood and satisfaction decreased after deferral, but were not directly responsible for low return rates. Age was found to have a significant influence on return behavior.
TRANSFUSION MEDICINE AND HEMOTHERAPY
(2021)
Article
Environmental Sciences
Klara Greffin, Silke Schmidt, Linda Schoenborn, Holger Muehlan
Summary: The study revealed that over one-third of participants have donated blood at least once, with primary motives for blood donation being altruism, social responsibility, and charity, while major deterrents include health status, age, and lack of time.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Clinical Neurology
Catherine Arnaud, Carine Duffaut, Jerome Fauconnier, Silke Schmidt, Kate Himmelmann, Marco Marcelli, Lindsay Pennington, Joaquim Alvarelhao, Chirine Cytera, Marion Rapp, Virginie Ehlinger, Ute Thyen
Summary: Inclusion for young people with disabilities in society is hindered by personal and environmental factors. Previous studies mainly focused on the transition period for CP patients, neglecting the impact of environmental barriers and severity of impairments. This study aims to investigate the influence of environment on participation and quality of life for young adults with CP, predictors of success in various areas, comparison with the general population, and documenting participation and quality of life for those with severe disabilities.
Article
Health Care Sciences & Services
Klara Greffin, Silke Schmidt, Neeltje van den Berg, Wolfgang Hoffmann, Oliver Ritter, Michael Oeff, Georg Schomerus, Holger Muehlan
Summary: Although telemedical applications are increasingly used in the area of both mental and physical illness, there is currently no quality of life (QoL) instrument that takes into account the specific context of the healthcare setting. This study aimed to determine a concept of quality of life in telemedical care to inform the development of a setting-sensitive patient-reported outcome measure. The majority of aspects that influence the QoL of patients dealing with chronic conditions or mental illnesses could be assigned to an established working model of QoL.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2021)
Article
Clinical Neurology
Eveline Janine Anna Wiegers, Hester Floor Lingsma, Jilske Antonia Huijben, David James Cooper, Giuseppe Citerio, Shirin Frisvold, Raimund Helbok, Andrew Ian Ramsay Maas, David Krishna Menon, Elizabeth Madeleine Moore, Nino Stocchetti, Diederik Willem Dippel, Ewout Willem Steyerberg, Mathieu van der Jagt
Summary: In this study, significant variability in fluid management was observed in critically ill patients with traumatic brain injury, with more positive fluid balances associated with worse outcomes. Neutral fluid balances aiming for normovolemia are suggested to contribute to improved outcomes.
Article
Environmental Sciences
Samuel Tomczyk, Maxi Rahn, Henriette Markwart, Silke Schmidt
Summary: The study found that participants who received a warning message and were confronted with a thunderstorm showed the highest increase in momentary anxiety, which predicted their intention to seek information. The virtual city framework helps differentiate the impact of warning versus event on individuals' emotions and behavioral intentions in an online context.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Thomas McLaren, Lina-Jolien Peter, Samuel Tomczyk, Holger Muehlan, Susanne Stolzenburg, Georg Schomerus, Silke Schmidt
Summary: The study aims to develop an anti-stigma intervention to support help-seeking behavior for individuals with depression, using a quasi-experimental online design with various intervention variables. The research could provide insights into understanding mental health care utilization stages and stigmatization theories, as well as inform the design and evaluation of online interventions for individuals with mental illnesses.
Article
Public, Environmental & Occupational Health
Samuel Tomczyk, Laura Altweck, Silke Schmidt
Summary: This study used latent profile analysis to identify six patterns of daily time use, revealing lower wellbeing scores in the care and part-time work & care profiles. Women were more likely to be in the care and childcare profiles, while men were more likely to belong to the full-time work profile and reported higher wellbeing than women.
Article
Health Care Sciences & Services
Silke Schmidt, Henriette Markwart, Marion Rapp, Audrey Guyard, Catherine Arnaud, Jerome Fauconnier, Ute Thyen, Stefanie Hahm, Nicolas Vidart D'Egurbide Bagazgoitia, Holger Muehlan
Summary: This study found that emerging adults with cerebral palsy have similar levels of quality of life compared to the general population, with the exception of the environmental domain. However, they experience worse levels of depression and self-efficacy. Pain and impairment have negative impacts on mental health outcomes.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2022)
Review
Psychiatry
S. Tomczyk, S. Schlick, T. Gansler, T. McLaren, H. Muehlan, L. -J. Peter, G. Schomerus, S. Schmidt
Summary: This article systematically reviews measures of continuum beliefs for mental health disorders. The findings suggest that psychometrically sound instruments are available to assess continuum beliefs in a variety of mental disorders. However, further research is needed to confirm these findings and to explore differences in beliefs among different populations and disorders.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Health Care Sciences & Services
Marina Zeldovich, Fabian Bockhop, Amra Covic, Isabelle Mueller, Suzanne Polinder, Ana Mikolic, Marjolein van der Vlegel, Nicole von Steinbuechel
Summary: This study examines the factorial validity and comparability of six language versions of the RPQ in the CENTER-TBI study. The results show that the translations of RPQ are largely comparable across languages and can be used in international research and clinical settings.
JOURNAL OF PATIENT-REPORTED OUTCOMES
(2023)
Article
Public, Environmental & Occupational Health
Claudia Helmert, Sven Speerforck, Toni Fleischer, Danielle Otten, Christoph Kasinger, Elmar Braehler, Holger Muehlan, Laura Altweck, Stefanie Hahm, Silke Schmidt, Matthias Reusche, Heide Glaesmer, Andreas Hinz, Nigar Reyes, Kerstin Wirkner, Christoph Engel, Georg Schomerus, Christine Ulke
Summary: The study found differences in desire for social distance toward people with mental illness within the city of Leipzig, with higher desired social distance corresponding with spatial differences, high levels of pessimism, high shame of being mentally ill, low social support, low socio-economic status, and older age.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Psychiatry
C. Ulke, T. Fleischer, H. Muehlan, L. Altweck, S. Hahm, H. Glaesmer, J. M. Fegert, M. Zenger, H. J. Grabe, S. Schmidt, M. E. Beutel, G. Schomerus, E. Braehler, S. Speerforck
Summary: The study found that socio-political context is an important determinant of childhood maltreatment among the German population, especially in women from West Germany. Future research should continue to focus on societal level risk and protective factors to develop evidence-based prevention strategies for safe and nurturing environments for children and families.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2021)
Article
Language & Linguistics
Marie Bischoff, Silke Schmidt, Holger Muehlan
Summary: The study found that children with high Humor Orientation exhibit better social competencies, emotion knowledge, quality of life, and lower trait anxiety. The CHO-10 scale was confirmed as a valid, reliable and economical measure of Child Humor Orientation.
HUMOR-INTERNATIONAL JOURNAL OF HUMOR RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Maxi Rahn, Samuel Tomczyk, Silke Schmidt
Summary: This study investigated the influence of hazard type and trait anxiety on different components of risk perception in response to warning messages. Results showed that while anticipated negative emotions decreased after receiving warning messages, changes in various components of risk perception were inconsistent across different types of hazards. The findings highlight the importance of considering both hazard characteristics and individual traits in crisis communication strategies.
