Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors andhCB2R Ligands To Combat Neurodegenerative Disorders

Neuroinflammation in Alzheimer's Disease: Mechanisms, Pathologic Consequences, and Potential for Therapeutic Manipulation

(2017) Kenneth Hensley   JOURNAL OF ALZHEIMERS DISEASE

Learning performances and vulnerability to amyloid toxicity in the butyrylcholinesterase knockout mouse

(2016) Tangui Maurice et al.   BEHAVIOURAL BRAIN RESEARCH

The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats

(2016) Nadia Khan et al.   BEHAVIOURAL BRAIN RESEARCH

Design, Synthesis, Biological Evaluation and Binding Mode Modeling of Benzimidazole Derivatives Targeting the Cannabinoid Receptor Type 1

(2015) Christian Espinosa-Bustos et al.   ARCHIV DER PHARMAZIE

New Approaches in the Design and Development of Cannabinoid Receptor Ligands: Multifunctional and Bivalent Compounds

(2015) Martin Nimczick et al.   ChemMedChem

Synthesis, Biological Evaluation, and Computational Studies of Tri- and Tetracyclic Nitrogen-Bridgehead Compounds as Potent Dual-Acting AChE Inhibitors and hH3 Receptor Antagonists

(2014) Fouad H. Darras et al.   ACS Chemical Neuroscience

Acetylcholinesterase Inhibitors with Photoswitchable Inhibition of β-Amyloid Aggregation

(2014) Xinyu Chen et al.   ACS Chemical Neuroscience

Synthesis and biological evaluation of bivalent cannabinoid receptor ligands based on hCB2R selective benzimidazoles reveal unexpected intrinsic properties

(2014) Martin Nimczick et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with ‘inverted’ binding mode

(2014) Fouad H. Darras et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Multi-target approach for natural products in inflammation

(2014) Andreas Koeberle et al.   DRUG DISCOVERY TODAY

Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine

(2014) Guozheng Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides

(2014) Valentina Lucchesi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase

(2013) Jinmei Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Modeling in vitro inhibition of butyrylcholinesterase using molecular docking, multi-linear regression and artificial neural network approaches

(2013) Fang Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cannabinoid Effects on β Amyloid Fibril and Aggregate Formation, Neuronal and Microglial-Activated Neurotoxicity In Vitro

(2013) Emelie Janefjord et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Multitarget Cannabinoids as Novel Strategy for Alzheimer Disease

(2013) Pedro Gonzalez-Naranjo et al.   Current Alzheimer Research

Multi-Target Compounds Acting in the Central Nervous System Designed From Natural Products

(2013) X. Chen et al.   CURRENT MEDICINAL CHEMISTRY

Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease

(2013) Pedro González-Naranjo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Search for New Inhibitors of Cholinesterases

(2013) Marek Bajda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual Targeting of Adenosine A2A Receptors and Monoamine Oxidase B by 4H-3,1-Benzothiazin-4-ones

(2013) Anne Stößel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of the cannabinoid system in the transit of beta-amyloid across the blood–brain barrier

(2013) Corbin Bachmeier et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Exploring the Chemical Space of Multitarget Ligands Using Aligned Self-Organizing Maps

(2013) Janosch Achenbach et al.   ACS Medicinal Chemistry Letters

Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice

(2012) Ana María Martín-Moreno et al.   Journal of Neuroinflammation

CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients

(2012) Maite Solas et al.   NEUROBIOLOGY OF AGING

Activation of the CB2 receptor system reverses amyloid-induced memory deficiency

(2012) Jiang Wu et al.   NEUROBIOLOGY OF AGING

WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-γ pathway

(2012) Gohar Fakhfouri et al.   NEUROPHARMACOLOGY

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

(2012) W. Liu et al.   SCIENCE

Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer

(2012) Fouad H. Darras et al.   ACS Medicinal Chemistry Letters

Homology modeling in tandem with 3D-QSAR analyses: A computational approach to depict the agonist binding site of the human CB2 receptor

(2011) Elena Cichero et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

DSX: A Knowledge-Based Scoring Function for the Assessment of Protein–Ligand Complexes

(2011) Gerd Neudert et al.   Journal of Chemical Information and Modeling

Dual inhibition: a novel promising pharmacological approach for different disease conditions

(2011) Sazal Patyar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

The emergence of designed multiple ligands for neurodegenerative disorders

(2011) Werner J. Geldenhuys et al.   PROGRESS IN NEUROBIOLOGY

Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1Receptor Antagonism

(2010) Jos H. M. Lange et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Structure−Activity Relationships of Cyanoguanidine-Type and Structurally Related Histamine H4Receptor Agonists§

(2009) Patrick Igel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors

(2009) T. E. Angel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel benzimidazole derivatives as selective CB2 agonists

(2008) Daniel Pagé et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Flexibility of Aromatic Residues in the Active-Site Gorge of Acetylcholinesterase: X-ray versus Molecular Dynamics

(2008) Yechun Xu et al.   BIOPHYSICAL JOURNAL

An efficient route to 3-aminoindazoles and 3-amino-7-azaindazoles

(2008) Michael J. Burke et al.   TETRAHEDRON LETTERS

A new efficient synthesis of isothiocyanates from amines using di-tert-butyl dicarbonate

(2008) Henrik Munch et al.   TETRAHEDRON LETTERS

In vitroandin vivocharacterization of A-796260: a selective cannabinoid CB2receptor agonist exhibiting analgesic activity in rodent pain models

(2007) B B Yao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synthesis, potent anti-staphylococcal activity and QSARs of some novel 2-anilinobenzazoles

(2007) Seçkin Özden et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY