Optimization of Inhibitors ofMycobacterium tuberculosisPantothenate Synthetase Based on Group Efficiency Analysis

The role of ligand efficiency metrics in drug discovery

(2014) Andrew L. Hopkins et al.   NATURE REVIEWS DRUG DISCOVERY

Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

(2013) H. L. Silvestre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface

(2012) Inge Van Molle et al.   CHEMISTRY & BIOLOGY

Pathway-Selective Sensitization of Mycobacterium tuberculosis for Target-Based Whole-Cell Screening

(2012) Garth L. Abrahams et al.   CHEMISTRY & BIOLOGY

Molecular obesity, potency and other addictions in drug discovery

(2011) Michael M. Hann   MedChemComm

Fragment-Based Deconstruction of Bcl-xLInhibitors

(2010) Sarah Barelier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor α7 Ligands

(2010) Gerdien E. de Kloe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimization of the Interligand Overhauser Effect for Fragment Linking: Application to Inhibitor Discovery againstMycobacterium tuberculosisPantothenate Synthetase

(2010) Pawel Sledz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Application of Fragment Growing and Fragment Linking to the Discovery of Inhibitors ofMycobacterium tuberculosisPantothenate Synthetase

(2009) Alvin W. Hung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Group Efficiency: A Guideline for Hits-to-Leads Chemistry

(2008) Marcel L. Verdonk et al.   ChemMedChem